Results 61 to 70 of about 2,093,931 (270)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Synthesis of aza-phenylalanine, aza-tyrosine, and aza-tryptophan precursors via hydrazine alkylation; pp. 168–178 [PDF]

Proceedings of the Estonian Academy of Sciences, 2015
Aza-amino acid precursors with an aromatic side chain were synthesized using hydrazine alkylation. This synthetic pathway avoided use of hydrogen gas and expensive hydrogenation catalysts. For the optimization of this alkylation reaction various solvents
Anton Mastitski, Tõiv Haljasorg, Karin Kipper, Jaak Järv   +3 more
doaj   +1 more source

On the Nature of Precursors in the Radio Pulsar Profiles

, 2007
In the average profiles of several radio pulsars, the main pulse is accompanied by the preceding component. This so called precursor is known for its distinctive polarization, spectral, and fluctuation properties.
Blandford R. D., Fowler L. A., Fowler L. A., Gil J. A., Lyubarskii Yu. E., McCulloch P. M., S. A. Petrova   +6 more
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Water chemistry and soil radon survey at the Poas volcano (Costa Rica)

Annals of Geophysics, 2005
Radon-in-soil monitoring at the Poas volcano (Costa Rica) has been performed together with water chemistry from the hot crater lake since 1981 and 1983 respectively.
J. L. Seidel, M. Monnin, E. Fernandez, J. Barquero, N. Segovia   +4 more
doaj   +1 more source

The protein import apparatus of chloroplasts [PDF]

, 1993
Routing of cytosolically synthesized precursor proteins into chloroplasts is a specific process which involves a multitude of soluble and membrane components.
Bartling D., Bassham D. C., Buvinger W. E., Cline K., Cline K., Cline K., Heike Alefsen, Joyard J., Jürgen Soll, Kirwin P. M., Li H.‐M., Mould R. M., Olsen L. J., Olsen L. J., Perry S. E., Pilon M., Schnell D. J., Theg S. M.   +17 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Mitochondrial import receptors for precursor proteins [PDF]

, 1991
The specific targeting of precursor proteins synthesized in the cytosol to various cell organelles is a central aspect of intracellular protein traffic. Several hundred different proteins are imported from the cytosol into the mitochondria.
Attardi, Baker, Deshaies, Gillespie, Hartl, Hines, Horwich, Hwang, Kang, Kiebler, Klingenberg, Meyer, Murakami, Murakami, Murakami, Ono, Pain, Pfaller, Pfaller, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Riezman, Roise, Rosenberg, Schnell, Sheffield, So¨llner, So¨llner, Steger, Vestweber, Wickner   +34 more
core   +1 more source