Results 91 to 100 of about 59,825 (253)

From Genomic and Epigenomic Maps to Medicines in Adult T‐Cell Leukemia/Lymphoma

Cancer Science, EarlyView.
ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive and refractory hematologic malignancy that is caused by human T‐cell leukemia virus type‐1 (HTLV‐1) retrovirus. ATL results from a combination of viral latency and the accumulation of abnormalities throughout the genome, epigenome, transcriptome, and signaling pathways.
Kako Suzuki, Makoto Yamagishi
wiley   +1 more source

Blinatumomab for the Treatment of Adult B-Cell Acute Lymphoblastic Leukemia: Toward a New Era of Targeted Immunotherapy

Biologics: Targets & Therapy, 2020
Miguel J Franquiz,1,2 Nicholas J Short2 1Baylor College of Medicine, Houston, TX, USA; 2Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence: Nicholas J ShortDepartment of Leukemia, The University of ...
Franquiz MJ, Short NJ
doaj  

Metabolic gatekeeper function of B-lymphoid transcription factors. [PDF]

, 2017
B-lymphoid transcription factors, such as PAX5 and IKZF1, are critical for early B-cell development, yet lesions of the genes encoding these transcription factors occur in over 80% of cases of pre-B-cell acute lymphoblastic leukaemia (ALL).
Borkhardt, Arndt, Braas, Daniel, Cazzaniga, Giovanni, Cazzaniga, Valeria, Chan, Lai N, Chen, Zhengshan, Cosgun, Kadriye Nehir, Dickins, Ross A, Ernst, Thomas, Geng, Huimin, Graeber, Thomas G, Hochhaus, Andreas, Hurtz, Christian, Koeffler, H Phillip, Konopleva, Marina, Kornblau, Steven M, Lee, Jae-Woong, Liu, Grace J, Milne, Thomas A, Müschen, Markus, Pufall, Miles A, Ross, Theodora S, Schjerven, Hilde, Shojaee, Seyedmehdi, Sánchez-García, Isidro, Xiao, Gang, Yamamoto, Keith R   +26 more
core  

Tumor‐infiltrating B cells participate in shaping the immunosuppressive microenvironment in solid tumors

International Journal of Cancer, Volume 158, Issue 5, Page 1156-1165, 1 March 2026.
Abstract Tumor‐infiltrating B cells (TIBs) exhibit dual roles in the tumor microenvironment (TME) of solid tumors. While they can enhance anti‐tumor immunity through antibody production and immune activation, certain subsets—such as regulatory B cells (Bregs) and immunosuppressive plasma cells—contribute to immune evasion by secreting inhibitory ...
Zhitong Li, Ziyang Shen, Yuxiang Sun, Pengcheng Zhu, Tongyan Liu, Rong Yin   +5 more
wiley   +1 more source

Prenatal origin of childhood AML occurs less frequently than in childhood ALL [PDF]

, 2006
Background While there is enough convincing evidence in childhood acute lymphoblastic leukemia (ALL), the data on the pre-natal origin in childhood acute myeloid leukemia (AML) are less comprehensive.
AM Ford, AT Maia, AT Maia, AT Maia, Bjoern Schneider, C Meyer, Claus Meyer, CM McHale, CM McHale, Felix Votava, GS Makowski, H Kempski, H Kiyoi, J Zuna, Jan Stary, Jan Trka, Jan Zuna, JL Wiemels, JL Wiemels, JL Wiemels, JL Wiemels, Jozef Madzo, JW Taub, K Fasching, Katerina Muzikova, KB Gale, KE Richkind, LK Jones, LL Hjalgrim, LY Shih, MD Megonigal, MF Greaves, MJ Pongers-Willemse, N Goulden, PD Kottaridis, Rolf Marschalek, S Meshinchi, SA Miller, SC Raimondi, T Szczepanski, T Yagi, Tatiana Burjanivova   +41 more
core   +3 more sources

DNTTIP1 drives leukaemogenesis through MiDAC‐mediated epigenetic silencing of BMF

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
DNTTIP1 cooperates with SP1 to recruit HDAC1/2, leading to BMF silencing and reduced competitive binding of BMF to BCL2.This suppresses autophagy and apoptosis, promoting leukaemic cell survival. Targeting the DNTTIP1‐HDAC1/2‐BMF axis reactivates BMF and induces anti‐leukaemic effects.
Ruolin Xiu, Yuzhu Ma, Yueying Gao, Yao Chen, Xinyu Li, Yue Wu, Meiling Sun, Qizhao Li, Yanhong Zhao, Shuqian Xu, Shengjin Fan, Yongsheng Li, Huitao Fan   +12 more
wiley   +1 more source

Additional file 1 of Haploidentical CD7 CAR T-cells induced remission in a patient with TP53 mutated relapsed and refractory early T-cell precursor lymphoblastic leukemia/lymphoma

, 2022
Additional file 1 : Supplementary Figure 1. Flow cytometry analysis on the anti-CD7 CAR T-cells. Supplementary Figure 2. Cytotoxicity analysis of the anti-CD7 CAR T-cells. Supplementary Figure 3. Timeline of treatments and responses. Supplementary Figure 4. T-cell fractions in the PB post CAR T-cells infusion. Supplementary Table 1.
Dai, Hai-ping, Cui, Wei, Cui, Qing-ya, Zhu, Wen-juan, Meng, Hui-min, Zhu, Min-qing, Zhu, Xia-ming, Yang, Lin, Wu, De-pei, Tang, Xiao-wen   +9 more
openaire   +1 more source

Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. [PDF]

, 2016
High hyperdiploidy (HD), the most common cytogenetic subtype of B-cell acute lymphoblastic leukemia (B-ALL), is largely curable but significant treatment-related morbidity warrants investigating the biology and identifying novel drug targets.
de Smith, Adam J, Endicott, Alyson A, Francis, Stephen S, Hansen, Helen M, Metayer, Catherine, Ojha, Juhi, Sanders, Erica, Smirnov, Ivan, Termuhlen, Amanda M, Walsh, Kyle M, Wiemels, Joseph L   +10 more
core   +1 more source

Early Toxicity in Childhood Acute Lymphoblastic Leukemia: A Comparison of NOPHO ALL2008 and ALLTogether Protocols in Sweden

Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT Background The European ALLTogether protocol for childhood acute lymphoblastic leukemia, initiated in Sweden 2019, introduced earlier asparaginase during induction, dexamethasone instead of prednisone for all patients, and omitted anthracyclines from low‐risk induction to reduce treatment‐related toxicity.
Johannes Fermér, Hannah van Bunningen, Otto Zhou, Jonas Abrahamsson, Magnus Borssen, Isabella Donnér, Mats Heyman, Anna Sällfors Holmqvist, Anders Valind, Hartmut Vogt, Susanna Ranta, Arja Harila   +11 more
wiley   +1 more source

A complete response with daratumumab, venetoclax, azacitidine and dexamethasone in a heavily pre-treated, chemo-refractory early T-precursor acute lymphoblastic leukemia/lymphoma patient

Annals of Hematology
Early T-precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) is a rare and aggressive subtype of T-cell leukemia with poor prognosis and resistance to standard treatments.
Sureyya Yigit Kaya, Mehrad Vatani, Rima Akil, Tansel Cakir, S. Maral, L. Kaynar, Ömür Gökmen Sevindik   +6 more
semanticscholar   +1 more source