Results 111 to 120 of about 59,825 (253)

CD30 as a Target Molecule in the Diagnosis and Therapy of Lymphomas

American Journal of Hematology, Volume 101, Issue 1, Page 110-128, January 2026.
ABSTRACT The tumor necrosis factor (TNF)‐receptor superfamily 8 receptor CD30 molecule is expressed in all tumor cells of Hodgkin lymphoma and anaplastic large cell lymphoma but is only weakly expressed in a small subset of large lymphoid cells in normal peripheral lymphoid tissues.
Harald Stein, Brunangelo Falini
wiley   +1 more source

Hypothalamic-pituitary-adrenal (HPA) axis suppression after treatment with glucocorticoid therapy for childhood acute lymphoblastic leukaemia [PDF]

, 2012
Background Glucocorticoids play a major role in the treatment of acute lymphoblastic leukaemia (ALL). However, supraphysiological doses may cause suppression of the hypothalamic-pituitary-adrenal (HPA) axis.
Abdu, Agwu, Albert, Bessho, Birkebaek, Böttner, Christensen, Cunha, Dickstein, Einaudi, Felder-Puig, Felner, Grimes, Henzen, Hettmannsperger, Hurwitz, Igarashi, Krasner, Kuperman, Laupacis, Lightner, Maghnie, Mahachoklertwattana, Nyhlén, Pawlaczyk, Petersen, Planey, Poele, Pruckner, Rao, Rix, Rubnitz, Schlaghecke, Shah, Shibata, Shulman, Silva, Tijn, Tordjman, Vanderschueren-Lodeweyckx, Waage, Wheeler   +41 more
core   +2 more sources

Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment

Cancer Medicine, Volume 15, Issue 1, January 2026.
Krüppel‐like factor 4 (KLF4) exhibits a dual, context‐dependent role, acting as both a tumor suppressor and an oncogene. It remodels the tumor microenvironment by modulating cancer, stromal, and immune cells, representing a promising yet complex therapeutic target for cancer treatment.
Min Tang, Binle Tian, Jingyi Zhou, Di Ma, Rongze Sun, Qi Li   +5 more
wiley   +1 more source

Mediastinal neoplasms in patients with Graves disease: a possible link between sustained hyperthyroidism and thymic neoplasia? [PDF]

, 2012
Background Anterior mediastinal masses are a rare but well documented finding in Graves disease. The vast majority of these lesions represents benign thymic hypertrophy and regress after treatment of the hyperthyroidism.
Boyd, Jonathan D, Juskevicius, Ridas
core   +2 more sources

Precursor B-Cell Lymphoblastic Leukemia-Lymphoma with severe eosinophilia, in a young adult patient

, 2020
Introduction: Acute lymphoblastic leukemia (ALL) of B cells, is the most common subtype of ALL in children.(1,2) ALL that presents as hypereosinophilia in peripheral blood, is very rare and the incidence is <1%.(3) Case Report: In this case, is presented a girl, 25 year old girl, initially diagnosed as community acquired pneumonia and leukemoid ...
Tello-Vera, Stalin, Novoa-Pérez, Karla
openaire   +1 more source

Blinatumomab in de novo AYA ALL—Results of the Australasian Leukaemia and Lymphoma Group ALL09 “SUBLIME” study

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Pediatric regimens improve outcomes in adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL) patients. End‐consolidation (time point 2 [TP2]) minimal residual disease negativity (MRDneg) is associated with improved survival. In this study, standard consolidation chemotherapy was replaced with blinatumomab to improve TP2 MRDneg—a ...
Matthew Greenwood, Shane Gangatharan, Michael Osborn, Ashley P. Ng, Shaun Fleming, Pasquale Fedele, Toby Trahair, John Casey, Sally Mapp, Carol Cheung, Tasman Armytage, Michelle Henderson, Rosemary Sutton, Jacqueline Rehn, Elyse Page, Susan Heatley, Peter Button, Leesa Rowley, Stephen R. Larsen, Peter Presgrave, John Kwan, Samuel Bennett, Chun Yew Fong, Luciano Dalla Pozza, David Yeung, Deborah White, the Australasian Leukaemia and Lymphoma Group   +26 more
wiley   +1 more source

Enhancing Circle‐of‐Care Communication in Pediatric Cancer Through Digital Health Technologies: A Scoping Review

Pediatric Blood &Cancer, Volume 73, Issue 1, January 2026.
ABSTRACT Effective communication in pediatric cancer care is crucial for informed decision‐making among patients, caregivers, and healthcare providers. This scoping review assesses evidence on digital tools designed to enhance circle‐of‐care communication for pediatric cancer patients and families.
Aljeena Rahat Qureshi, Kaitlyn Flegg, Ashar Siddiqui, Brendan K. Tao, Brenda Gallie   +4 more
wiley   +1 more source

Acute Lymphoblastic Leukemia Presenting as Acute Vogt-Koyanagi-Harada Syndrome

Case Reports in Ophthalmology, 2020
We aimed to describe a case of acute lymphoblastic leukemia (ALL) that initially presented and was managed as Vogt-Koyanagi-Harada syndrome (VKH). A 62-year-old man was referred for vision loss starting 1 week ago.
Narges Hassanpoor, Mohamad Reza Niyousha   +1 more
doaj   +1 more source

Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia [PDF]

, 2015
Several chemo-resistance mechanisms including the Bcl-2 protein family overexpression and constitutive activation of the PI3K/Akt/mTOR signaling have been documented in acute lymphoblastic leukemia (ALL), encouraging targeted approaches to circumvent ...
ALLEGRETTI, MATTEO, Bergamo, P, FOA, Roberto, Iacovelli, S, LICCHETTA, ROBERTO, Martelli, Am, Mccubrey, Ja, Milella, M, MIRABILII, SIMONE, RICCIARDI, Maria Rosaria, Rinaldo, C, TAFURI, Agostino, Zeuner, A   +12 more
core   +1 more source

Convergent Multistage Evidence Implicates the CCR2–Artemin Immune–Inflammation Axis in Acute Myeloid Leukemia

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Background The immune system and inflammatory proteins influence hematologic malignancies, but causal links with immune cell phenotypes are unclear. Methods We applied a prespecified, multistage workflow: two‐sample and multivariable Mendelian randomization (MVMR; 731 immune traits across 12 hematologic cancers), two‐step mediation Mendelian ...
Yi Jin, Hui-Min Lu, Xing-Hao Yu, Ming-Zhu Su, Jun Li, Xiao-Min Li, Jian-Hua Jin, Li-Ting Zhang, Yue Wang, Mirella Giovarelli   +9 more
wiley   +1 more source