Results 61 to 70 of about 17,590 (203)

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy

VIEW, EarlyView.
Abstract Immuno‐oncology represents an emerging field that has significantly transformed tumor therapeutics, with immune cells serving as the cellular foundations of cancer immunotherapy. Due to its high efficiency and sensitivity, CRISPR/Cas9 genome editing is a highly promising technique for precise and rapid gene modification.
Yuhui Ma, Junxin Chen, Yuan Du, Zhihao Cao, Weizhi Ji, Yuyu Niu, Zebin Yang   +6 more
wiley   +1 more source

The Application of Artificial Intelligence‐Based Bone Marrow Cell Analysis System in Pediatric Hematological Diseases

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction The clinical diagnosis of hematological diseases depends on the differential count of nucleated cells on the bone marrow (BM) smears, and an artificial intelligence (AI)‐based system was applied to automatically classify BM nucleated cells in pediatric hematological disease samples in this study.
Xin He, Fei He, Yan Wang, Yu Liu, Xiaopeng Gao, Mingrui Yu, Haiyan Gao   +6 more
wiley   +1 more source

The experience of relapsed Burkitt lymphoma treatment with targeted drugs and autologous/allogeneic stem cell transplantation

Онкогематология
The use of high-effective, multicomponent, risk-adopted chemoimmunotherapy schemes in children with Burkitt lymphoma reached advanced long-term progression-free survival over 90 % even for high risk patients.
T. T. Valiev, A. A. Khachatryan, S. V. Goryacheva, N. A. Batmanova, K. I. Kirgizov, S. R. Varfolomeeva   +5 more
doaj   +1 more source

The Landscape of Cancer Metabolism as a Therapeutic Target

Pathology International, EarlyView.
ABSTRACT Cancer cells reprogram their metabolism during progression to adapt to the tumor microenvironment, which is characterized by distinct differences in nutrient availability, oxygen concentrations, and acidity. This metabolic reprogramming can simultaneously create metabolic vulnerabilities unique to cancer cells, making cancer metabolism a ...
Kenji Ohshima
wiley   +1 more source

Impact of cellular composition and T‐cell senescence of mononuclear cell concentrates on the manufacturing process of chimeric antigen receptor (CAR) T‐cells

Transfusion, EarlyView.
Abstract Background Apheresis procedure of autologous lymphocytes competent for proliferation and expansion is a crucial step in the production of chimeric antigen receptor (CAR) T‐cells. Previous therapies or disease status prior to collection may negatively impact the collections.
Vladan Vučinić, Theresa Tumewu, Mandy Brückner, Janine Kirchberg, Madlen Jentzsch, Raymund Buhmann, Yvonne Remane, Sandra Hoffmann, Florian Ramdohr, Maximilian Merz, Klaus H. Metzeler, Sebastian Schwind, Carmen Herling, Simon M. Krauß, Marco Herling, Georg‐Nikolaus Franke, Nora Grieb, Georg Stachel, Martin Janz, Olaf Penack, Lars Bullinger, Ulrich Keller, Michael Cross, Reinhard Henschler, Enrica Bach, Uwe Platzbecker   +25 more
wiley   +1 more source

Impacts of Vincristine and Prednisolone Chemotherapy on the Canine Gut Microbiota in Dogs Undergoing Treatment for Lymphoma

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Chemotherapy can have adverse gastrointestinal effects in dogs and people. The objective of this study was to assess the impact of vincristine and prednisolone/prednisone, as part of a CHOP chemotherapy [cyclophosphamide, hydroxydaunorubicin, oncovin (vincristine) and prednisolone/prednisone] protocol, on gastrointestinal dysbiosis in dogs ...
Juan Aragon, Annika M. Weber, Madison Tipton, Jennifer Thomsen, Hend Ibrahim, Kristen Weishaar, Sangeeta Rao, Jan S. Suchodolski, Jonathan Stockman, Elizabeth P. Ryan, Nora Jean Nealon   +10 more
wiley   +1 more source

Flow Cytometry in the Differential Diagnosis of Lymphocyte-Rich Thymoma From Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma [PDF]

, 2004
Shiyong Li, Jonathan Juco, Karen P. Mann, Jeannine T. Holden   +3 more
openalex   +2 more sources

Diagnosis and Classification of Primary Nodal Lymphomas in Dogs: A Consensus of the Oncology‐Pathology Working Group

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT One of the primary objectives of the Oncology Pathology Working Group (OPWG) is for oncologists and pathologists to collaboratively generate consensus documents to standardise aspects of and provide guidelines for oncologic pathology in veterinary species.
Michael O. Childress, Anne Avery, Erica Behling‐Kelly, Peter Bennett, Laura Brockley, Ryan Dickinson, Kelly Hughes, William C. Kisseberth, Laura Marconato, Valeria Martini, Angela McCleary‐Wheeler, Lucia Minoli, Peter Rowland, Shane Sills, Luca Aresu   +14 more
wiley   +1 more source

Mitochondrial Dysfunction in Aging: Future Therapies and Precision Medicine Approaches

MedComm – Future Medicine, Volume 4, Issue 3, September 2025.
Mitochondria play a critical role in aging and aging‐related diseases. This review systematically explores the mechanisms underlying mitochondrial deterioration during aging and highlights innovative therapeutic strategies for these mitochondrial problems.
Lanlan Jia, Ziyu Wei, Jinyuan Luoqian, Xi Wang, Chao Huang   +4 more
wiley   +1 more source

Lymphoid Malignancies in Ataxia–Telangiectasia: Experience with Novel Targeted Therapies

Pediatric Blood &Cancer, Volume 72, Issue 9, September 2025.
ABSTRACT Patients with ataxia–telangiectasia (AT) face unique challenges in managing lymphoid malignancies due to heightened sensitivity to chemotherapy and radiation, requiring alternative treatment strategies. This report presents three cases demonstrating the successful integration of targeted therapies: ibrutinib for diffuse large B‐cell lymphoma ...
Samanta Catueno, Ramya Ramakrishnan, Sarah Elitzur, Miriam B. Garcia, David McCall, Cesar Nunez, Michael Roth, Alessandra Ferrajoli, Branko Cuglievan, Amber Gibson   +9 more
wiley   +1 more source