Results 191 to 200 of about 104,139 (265)

Single Cell RNA Transcriptomics of Mantle Cell Lymphoma Reveals the Presence of Treatment‐Resistant Subclones at the Time of Diagnosis

American Journal of Hematology, Volume 101, Issue 5, Page 1025-1035, May 2026.
ABSTRACT Mantle cell lymphoma (MCL) is a B‐cell malignancy with a chronically relapsing clinical course and pronounced genetic heterogeneity. To investigate the clonal dynamics underlying early disease relapse, we performed single‐cell RNA sequencing of paired tumor samples collected at diagnosis and at first relapse. Inference of copy number variants (
Dmitry Manakov, Magdalena Klanova, Michal Kolar, Robert Ivanek, Florian Geier, Julien Roux, Tomas Zikmund, Lucie Winkowska, Eva Kriegova, Jirina Manakova, Liliana Tuskova, Silvia Spanikova, Alexandra Scasna, Marek Trneny, Pavel Klener   +14 more
wiley   +1 more source

Single-cell multiomic atlas of healthy pediatric bone marrow reveals age-dependent differences in lineage differentiation driven by stromal signaling. [PDF]

Nat Immunol
Hanemaaijer ES, Müskens KF, Kal IJ, Chen LT, Te Pas BM, Fryzik P, Epskamp N, van der Meulen M, Balwierz AK, Saikumar Jayalatha AK, Scheijde-Vermeulen M, Heidenreich O, Candelli T, de Jonge WJ, Margaritis T, Belderbos ME.   +15 more
europepmc   +1 more source

Putative Clonal Evolution in a PHF6‐Mutant T/NK‐Cell Lymphoproliferative Disorder With Selective Loss of a STAT5B‐Mutant Subclone

eJHaem, Volume 7, Issue 3, June 2026.
Mark Anthony Turingan, Cuihong Wei, Nihad Almokhtar, Abi Vijenthira, Hong Chang   +4 more
wiley   +1 more source

GLP‐1 agonists and the gut microbiome: A bidirectional relationship

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1309-1325, May 2026.
Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research.
Srinivas Kamath, Nicole S. L. Chan, Paul Joyce   +2 more
wiley   +1 more source

Targeting of Gut Microbiota by Bioactive Peptides for the Improvement of Metabolic Diseases: A Review

Food Frontiers, Volume 7, Issue 3, May 2026.
Bioactive peptides (BPs) derived from dietary proteins modulate the gut microbiotametabolism axis by reshaping microbial composition and regulating key metabolites, including short‐chain fatty acids. BPs also enhance intestinal barrier integrity and immune homeostasis, thereby reducing inflammation.
Jiao Li, Yongchao Chen, Zhihua Li, Gang Liu, Hongmei Jiang, Jun Fang, Sujuan Ding   +6 more
wiley   +1 more source

Case report: a case of primary cutaneous diffuse large B-cell lymphoma, leg type with TdT positive in an elderly woman. [PDF]

Diagn Pathol
Zheng J, Li X, Chen H.
europepmc   +1 more source

Gut Microbiota and Extraintestinal Cancers: Mechanistic Insights and Microbiome‐Targeted Interventions

JGH Open, Volume 10, Issue 5, May 2026.
ABSTRACT The gut microbiota is a dynamic community of bacteria, viruses, fungi, and archaea that plays a pivotal role in regulating host immunity, metabolism, and systemic homeostasis. Dysbiosis, characterized by an imbalance in the microbial composition, is being increasingly recognized as a contributor not only to gastrointestinal cancers but also to
Rishi Chowdhary, Manjeet Kumar Goyal, Kirti Arora, Tanisha Sehgal, Prachi Dawer, F. N. U. Anirudh, Jeffrey Berinstein, Shrinivas Bishu, Laurie Matt‐Amaral   +8 more
wiley   +1 more source

CD127⁺ Natural Killer Cells Represent a Distinct, Interleukin-15-Independent and Thymus-Independent Subset in Mice. [PDF]

Int J Mol Sci
Kim Y, Hwang SY, Kwon YJ, Kim JE, Rajbongshi L, Lee SR, Joo S, Park S, Oh SO, Kim BS, Lee D, Yoon S.   +11 more
europepmc   +1 more source

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Acquired nonpermissive BM microenvironment impairs HSC proliferation and maintenance, and B-cell development after HSCT. [PDF]

Blood Adv
de Gier M, Korzhenevich J, Schmidt FM, Janowska I, van Ostaijen-Ten Dam MM, Pico-Knijnenburg I, Cats D, Keller F, Hadlova P, Kunze M, Markfeld-Erol F, Reising K, Mei H, Bredius RGM, Lankester AC, van der Burg M, Rizzi M.   +16 more
europepmc   +1 more source