Results 111 to 120 of about 2,128,536 (388)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Spectral precursors of paroxysmal phases of Stromboli

Annals of Geophysics, 1996
In this work we investigate the characteristics of the seismicity at Stromboli volcano during more than two years, i.e. from 11 May 1992 to 21 August 1994.
F. Iacop, R. Carniel
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

A Case Study of Ozone Pollution in a Typical Yangtze River Delta City During Typhoon: Identifying Precursors, Assessing Health Risks, and Informing Local Governance

Atmosphere
Ozone (O3) is a crucial atmospheric component that significantly affects air quality and poses considerable health risks to humans. In the coastal areas of the Yangtze River Delta, typhoons, influenced by the subtropical high-pressure system, can lead to
Mei Wan, Xinglong Pang, Xiaoxia Yang, Kai Xu, Jianting Chen, Yinglong Zhang, Junyue Wu, Yushang Wang   +7 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Author response for "Modulation of aroma compounds in yeast and lactic acid bacterium co‐fermented pork hydrolysates by thermal treatment and addition of aroma precursors (cysteine and xylose)"

, 2021
Xinzhi Li, Shao‐Quan Liu
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Assessing the PM_2.5–O₃ Correlation and Unraveling Their Drivers in Urban Environment: Insights from the Bohai Bay Region, China

Atmosphere
Understanding the correlation between PM2.5 and O3 is critical for complex air pollution control. This study comprehensively analyzed PM2.5 and O3 pollution characteristics, uncovered spatiotemporal variations in their correlation, and investigated the ...
Yan Nie, Yongxin Yan, Yuanyuan Ji, Rui Gao, Yanqin Ren, Fang Bi, Fanyi Shang, Jidong Li, Wanghui Chu, Hong Li   +9 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Quantum correlations as precursors of entanglement

, 2010
We show that for two initially excited qubits, interacting via dipole forces and with a common reservoir, entanglement is preceded by the emergence of quantum and classical correlations.
Auyuanet, Adriana, Davidovich, Luiz
core   +1 more source