Results 231 to 240 of about 49,811 (292)

GLP‐1 Receptor Agonists in Metabolic Dysfunction‐Associated Steatotic Liver Disease: Bridging Hepatic and Cardiovascular Outcomes

Chronic Diseases and Translational Medicine, Volume 12, Issue 2, Page 85-99, June 2026.
Endogenous GLP‐1 and exogenous GLP‐1 RAs activate GLP‐1R‐expressing vagal afferents in the portal vein, projecting to the nucleus tractus solitarius (NTS). This input engages brainstem–hypothalamic circuits that regulate metabolic homeostasis. Hypothalamic efferent vagal output to the liver suppresses lipogenesis, enhances triglyceride export, and ...
Gabriel Amorim Moreira Alves, Masatoki Teranishi, Rajendranandini Majumdar, Fazal Khan, Mohan Dodeja, Ana Claudia Teixeira de Castro Gonçalves Ortega, Marco Acerboni, Arosh S. Perera Molligoda Arachchige, Frank James   +8 more
wiley   +1 more source

Pancreatic Islet Cell Crosstalk: Insight Into α‐/β‐Cell Compensatory Mechanisms

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
α‐cell remodeling compensates for impaired β‐cell function. Intra‐islet glucagon/GLP‐1 signaling is upregulated and becomes essential in prediabetic islets. Flexible receptor engagement reflects functional plasticity in hormonal control of insulin secretion. Created in BioRender. Plecita, L. (2026); https://BioRender.com/pgjjg3m.
Štěpánka Benáková, Blanka Holendová, Jurij Dolenšek, Monika Křivonosková, Andraž Stožer, Lydie Plecitá‐Hlavatá   +5 more
wiley   +1 more source

Long‐term trends in metabolic profiles across Chinese birth cohorts: A real‐world big data analysis

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
• Younger generations (1980s–1990s) exhibit higher fasting glucose and rebounding total cholesterol and low‐density lipoprotein cholesterol, alongside declining high‐density lipoprotein cholesterol and triglycerides compared to 1930s–1970s cohorts.
Ying Xiong, Xincen Duan, Jing Zhu, Jiayi Huang, Baishen Pan, Wenqi Shao, Beili Wang, Wei Guo   +7 more
wiley   +1 more source

Nutraceutical Evaluation of Biscuits Formulated From Acha, Chia, and Soycake Flours on Glycemic Control, Lipid Profile, and Histopathological Effects in High‐Fat Diet/Streptozotocin‐Induced Type 2 Diabetic Rats

Food Chemistry International, Volume 2, Issue 2, Page 164-174, June 2026.
Acha–chia–soycake biscuits improved glucose tolerance, lipid profile, insulin levels, and pancreatic integrity in HFD–STZ diabetic rats. ACSB1 and ACSB13 outperformed acarbose, showing potent antihyperglycemic, hypolipidemic, and pancreatic‐protective effects.
Oluwafunmilayo Christianah Ogunnowo, Olufunmilayo Sade Omoba, Aderonke Ibidunni Olagunju, Olamide Wilson Fasakin, Idowu Sunday Oyeleye, Olajide Raymond Ojo   +5 more
wiley   +1 more source

Correlation Between Dietary Index for Gut Microbiota With All‐Cause and Cardiovascular Mortality in Cardiovascular‐Kidney‐Metabolic Syndrome Patients

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This study first demonstrates that in CKM syndrome patients, a higher dietary index for gut microbiota (DI‐GM) is associated with lower all‐cause and cardiovascular mortality. Each 1‐point increase in DI‐GM reduces all‐cause mortality risk by 10% and cardiovascular mortality by 12%.
Anwu Huang, Lianglei Hou, Shanjiang Chen, Bin Lin, Qinqin Zhang   +4 more
wiley   +1 more source

Cardiometabolic Risk and Structural Brain Development in a Large Community‐Based US Cohort

Human Brain Mapping, Volume 47, Issue 8, June 1, 2026.
In a large longitudinal cohort of US youth, cardiometabolic risk factors showed predominantly null associations with global brain structure across adolescence. Aside from modest links between higher BMI and thinner cortex, and higher resting heart rate and white matter microstructure, cardiometabolic variation did not track within‐person brain change ...
Dani Beck, Lars T. Westlye, Christian K. Tamnes   +2 more
wiley   +1 more source

Correction: Does menopause influence the association between atherogenic index of plasma and prediabetes? A cross-sectional study in middle-aged Chinese women. [PDF]

PLoS One
PLOS One Staff.
europepmc   +1 more source

The Association Between Fibrosis‐4 Index and All‐Cause and Cardiac Mortality in Patients With Coronary Heart Disease Combined With Diabetes or Prediabetes: Findings From Two Large‐Scale Prospective Cohort Studies

MedComm, Volume 7, Issue 6, June 2026.
The current study used two large‐scale cohorts to investigate the association between FIB‐4 index and all‐cause and cardiac‐mortality risk. Elevated FIB‐4, both as categorical and continuous variable, was associated with increased risk of all‐cause and cardiac‐mortality. ABSTRACT Determining the link between fibrosis‐4 index (FIB‐4) score, which serves
Chenxi Song, Zhihao Zheng, Xiaohui Bian, Zheng Qiao, Jiaxi Cheng, Wanqing Sun, Chunyue Wang, Bowen Li, Pengyu Liu, Yuqin He, Rui Fu, Kefei Dou   +11 more
wiley   +1 more source

β-cell recovery revisited: Is prediabetes remission driven by insulin sensitivity or β-cell function? [PDF]

J Diabetes Investig
Lee J, Yoon KH.
europepmc   +1 more source

Beyond the Known and Established Neurodegenerative Effects: Roles of APOE Across a Wide Spectrum of Pathophysiological Condition

MedComm, Volume 7, Issue 6, June 2026.
APOE is widely recognized for its role in neurodegeneration and cardiovascular disease, but its different genotypes also influence body composition, affecting obesity, bone density, and muscle mass, through their central role in lipid transport and metabolism.
Miriam Frosina, Samantha Maurotti, Alberto Castagna, Tiziana Montalcini, Arturo Pujia, Luca Tirinato   +5 more
wiley   +1 more source