Results 131 to 140 of about 6,504,273 (325)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Predictability [PDF]

British Journal of Ophthalmology, 1997
openaire   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

SAMOS Air‐Sea Fluxes: 2005–2024

Geoscience Data Journal
An updated dataset of air/sea turbulent fluxes has been created for 2005–2024 using three bulk flux algorithms and input data from a collection of research vessels contributing to the Shipboard Automated Meteorological and Oceanographic Systems (SAMOS ...
Marc Castells, Shawn R. Smith, Amanda Lovett, Mark A. Bourassa   +3 more
doaj   +1 more source

Predictive Likelihood

The Annals of Statistics, 1979
The likelihood function is the common basis of all parametric inference. However, with the exception of an ad hoc definition by Fisher, there has been no such unifying basis for prediction of future events, given past observations. This article proposes a definition of predictive likelihood which can help to remove some nonuniqueness problems in ...
openaire   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Drivers of sub‐seasonal extreme rainfall and their representation in ECMWF forecasts during the Eastern African March‐to‐May seasons of 2018–2020

Meteorological Applications
In recent years, Eastern Africa has been severely impacted by extreme climate events such as droughts and flooding. In a region where people's livelihoods are heavily dependent on climate conditions, extreme hydrometeorological events can exacerbate ...
Masilin Gudoshava, Patricia Nyinguro, Joshua Talib, Caroline Wainwright, Anthony Mwanthi, Linda Hirons, Felipe deAndrade, Joseph Mutemi, Wilson Gitau, Elisabeth Thompson, Jemimah Gacheru, John Marsham, Hussen Seid Endris, Steven Woolnough, Zewdu Segele, Zachary Atheru, Guleid Artan   +16 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

China’s Well-Facilitated Farmland distribution dataset

Scientific Data
China has less than 10% of the world’s arable land but must feed more than 20% of the global population. Both climate change and farmland degradation pose significant challenges to China’s food security. In 2009, Chinese government launched a nationwide,
Abdusalam Turup, Jun Zhang, Wenchao Ma, Bingxin Ma, Yue Zhang, Zaeem Hassan Akhter, Longhui Li   +6 more
doaj   +1 more source

Predictive Medicine

, 2015
In the last part of the twentieth century, predictive medicine has gained currency as an important ideal in biomedical research and health care. Research in the genetic and molecular basis of disease suggested that the insights gained might be used to develop tests that predict the future health state of asymptomatic individuals.
openaire   +2 more sources