Results 111 to 120 of about 5,688,119 (294)
Geoscience Letters, 2019 The Makran Accretionary Wedge (900 km across) is a consequence of northward subduction of the oceanic part of the Arabian Plate beneath the Lut and Afghan blocks in the northwestern Indian Ocean.
Mohammad Mokhtari +3 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Impact of Cloud Microphysics Initialization Using Satellite and Radar Data on CMA-MESO Forecasts
Remote SensingHigh-resolution numerical weather prediction requires accurate cloud microphysical initial conditions to enhance forecasting capabilities for high-impact severe weather events such as convective storms.
Lijuan Zhu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Meteorological ApplicationsAccurate representation of forecast uncertainty is essential for effective ensemble forecasting. To quantify the strengths and weaknesses of the China Meteorological Administration (CMA) convection‐permitting ensemble prediction system (CPEPS) in ...
Jingzhuo Wang +4 more
doaj +1 more source
应用气象学报Satellite data assimilation pre-processing plays a crucial role in bridging satellite data pre-processing and numerical weather prediction model assimilation.
Ma Gang +7 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Sensory prediction errors predict motor prediction errors
AbstractWhen sensory inputs can be predicted by an organism’s own actions or external environmental cues, neural activity is often attenuated compared to sensory inputs that are unpredictable. We have recently demonstrated that attenuation to predictable inputs is also observed when stimulating the motor system with transcranial magnetic stimulation ...
Dominic M. D. Tran +4 more
openaire +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source