Results 101 to 110 of about 5,688,119 (294)

Efficiency Evaluation of Character-level RNN Training Schedules [PDF]

, 2016
We present four training and prediction schedules from the same character-level recurrent neural network. The efficiency of these schedules is tested in terms of model effectiveness as a function of training time and amount of training data seen. We show
Bohez, Steven, De Boom, Cedric, Demeester, Thomas, Dhoedt, Bart, Leroux, Sam, Simoens, Pieter   +5 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Implementation and Evaluation of Storm‐Following 3DIAU for Hurricane Intensity Prediction Improvements in Operational HAFS

Earth and Space Science
Accurate hurricane intensity prediction remains a critical challenge in numerical weather prediction (NWP). This study implements and evaluates a newly developed Storm‐Following Three‐Dimensional Incremental Analysis Update (3DIAU) methodology for high ...
Xu Lu, Yonghui Weng, Bin Liu, Zhan Zhang, Xuguang Wang, Jing Cheng, Shun Liu, Daryl Kleist, Vijay Tallapragada   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Changes in a Giant Iceberg Created from the Collapse of the Larsen C Ice Shelf, Antarctic Peninsula, Derived from Sentinel-1 and CryoSat-2 Data

Remote Sensing, 2019
The giant tabular iceberg A68 broke away from the Larsen C Ice Shelf, Antarctic Peninsula, in July 2017. The evolution of A68 would have been affected by both the Larsen C Ice Shelf, the surrounding sea ice, and the nearby shallow seafloor. In this study,
Hyangsun Han, Sungjae Lee, Jae-In Kim, Seung Hee Kim, Hyun-cheol Kim   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Porphyra Polysaccharides Alleviated High-Carbohydrate Diet-Induced Growth Retardation, Lipid Deposition, Impairment of Immune and Antioxidant Functions, and Intestinal Morphology in Rabbitfish (Siganus canaliculatus)

Aquaculture Nutrition
Porphyra polysaccharide (PPS), derived from marine red seaweeds of the Porphyra genus, has been reported to improve growth performance, lipid metabolism, and antioxidant capability in animals.
Ruixin Li, Wenkai Li, Jiaying Xie, Zhixiao Liu, Yi Xiao, Douglas R. Tocher, Cuiying Chen, Fan Lin, Xiaojuan Liu, Dizhi Xie, Yucong Hong, Shuqi Wang   +11 more
doaj   +1 more source