Results 91 to 100 of about 1,655,273 (269)

The predictive Lasso

Statistics and Computing, 2011
We propose a shrinkage procedure for simultaneous variable selection and estimation in generalized linear models (GLMs) with an explicit predictive motivation. The procedure estimates the coefficients by minimizing the Kullback-Leibler divergence of a set of predictive distributions to the corresponding predictive distributions for the full model ...
Minh-Ngoc Tran, David J. Nott, Chenlei Leng   +2 more
openaire   +2 more sources

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

A review of the seismotectonics of the Makran Subduction Zone as a baseline for Tsunami Hazard Assessments

Geoscience Letters, 2019
The Makran Accretionary Wedge (900 km across) is a consequence of northward subduction of the oceanic part of the Arabian Plate beneath the Lut and Afghan blocks in the northwestern Indian Ocean.
Mohammad Mokhtari, Ahmad Ala Amjadi, Leila Mahshadnia, Mandana Rafizadeh   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Diagnostic Evaluation of Spread–Skill Relationships for Convection‐Permitting Ensemble Prediction System

Meteorological Applications
Accurate representation of forecast uncertainty is essential for effective ensemble forecasting. To quantify the strengths and weaknesses of the China Meteorological Administration (CMA) convection‐permitting ensemble prediction system (CPEPS) in ...
Jingzhuo Wang, Jing Chen, Fajing Chen, Guo Deng, Chen Liang   +4 more
doaj   +1 more source

Impact of Cloud Microphysics Initialization Using Satellite and Radar Data on CMA-MESO Forecasts

Remote Sensing
High-resolution numerical weather prediction requires accurate cloud microphysical initial conditions to enhance forecasting capabilities for high-impact severe weather events such as convective storms.
Lijuan Zhu, Yuan Jiang, Jiandong Gong, Dan Wang   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Review of Pre-processing Techniques for Meteorological Satellite Data Assimilation in Numerical Prediction

应用气象学报
Satellite data assimilation pre-processing plays a crucial role in bridging satellite data pre-processing and numerical weather prediction model assimilation.
Ma Gang, Huang Jing, Gong Xinya, Xi Shuang, Xue Lei, Li Juan, Zhang Peng, Gong Jiandong   +7 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Porphyra Polysaccharides Alleviated High-Carbohydrate Diet-Induced Growth Retardation, Lipid Deposition, Impairment of Immune and Antioxidant Functions, and Intestinal Morphology in Rabbitfish (Siganus canaliculatus)

Aquaculture Nutrition
Porphyra polysaccharide (PPS), derived from marine red seaweeds of the Porphyra genus, has been reported to improve growth performance, lipid metabolism, and antioxidant capability in animals.
Ruixin Li, Wenkai Li, Jiaying Xie, Zhixiao Liu, Yi Xiao, Douglas R. Tocher, Cuiying Chen, Fan Lin, Xiaojuan Liu, Dizhi Xie, Yucong Hong, Shuqi Wang   +11 more
doaj   +1 more source