Results 71 to 80 of about 1,741,048 (219)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Porphyra Polysaccharides Alleviated High-Carbohydrate Diet-Induced Growth Retardation, Lipid Deposition, Impairment of Immune and Antioxidant Functions, and Intestinal Morphology in Rabbitfish (Siganus canaliculatus)

Aquaculture Nutrition
Porphyra polysaccharide (PPS), derived from marine red seaweeds of the Porphyra genus, has been reported to improve growth performance, lipid metabolism, and antioxidant capability in animals.
Ruixin Li, Wenkai Li, Jiaying Xie, Zhixiao Liu, Yi Xiao, Douglas R. Tocher, Cuiying Chen, Fan Lin, Xiaojuan Liu, Dizhi Xie, Yucong Hong, Shuqi Wang   +11 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Impact of Cloud Microphysics Initialization Using Satellite and Radar Data on CMA-MESO Forecasts

Remote Sensing
High-resolution numerical weather prediction requires accurate cloud microphysical initial conditions to enhance forecasting capabilities for high-impact severe weather events such as convective storms.
Lijuan Zhu, Yuan Jiang, Jiandong Gong, Dan Wang   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Review of Pre-processing Techniques for Meteorological Satellite Data Assimilation in Numerical Prediction

应用气象学报
Satellite data assimilation pre-processing plays a crucial role in bridging satellite data pre-processing and numerical weather prediction model assimilation.
Ma Gang, Huang Jing, Gong Xinya, Xi Shuang, Xue Lei, Li Juan, Zhang Peng, Gong Jiandong   +7 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Diagnostic Evaluation of Spread–Skill Relationships for Convection‐Permitting Ensemble Prediction System

Meteorological Applications
Accurate representation of forecast uncertainty is essential for effective ensemble forecasting. To quantify the strengths and weaknesses of the China Meteorological Administration (CMA) convection‐permitting ensemble prediction system (CPEPS) in ...
Jingzhuo Wang, Jing Chen, Fajing Chen, Guo Deng, Chen Liang   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source