Results 81 to 90 of about 3,533,074 (286)
The expanding role of dopamine
eLife, 2016 Evidence increasingly suggests that dopaminergic neurons play a more sophisticated role in predicting rewards than previously thought.
Bradley B Doll, Nathaniel D Daw
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
STATISTICAL CHARACTERISTICS INVESTIGATION OF PREDICTION ERRORS FOR INTERFEROMETRIC SIGNAL IN THE ALGORITHM OF NONLINEAR KALMAN FILTERING [PDF]
Научно-технический вестник информационных технологий, механики и оптики, 2016 Basic peculiarities of nonlinear Kalman filtering algorithm applied to processing of interferometric signals are considered. Analytical estimates determining statistical characteristics of signal values prediction errors were obtained and analysis of ...
E. L. Dmitrieva, I. P. Gurov
doaj
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Error by design: Methods for predicting device usability [PDF]
, 2002 This paper introduces the idea of predicting ‘designer error’ by evaluating devices using Human Error Identification (HEI) techniques. This is demonstrated using Systematic Human Error Reduction and Prediction Approach (SHERPA) and Task Analysis For ...
Baber, Christopher +4 more
core +1 more source
Neuronal Coding of Prediction Errors
Annual Review of Neuroscience, 2000 Associative learning enables animals to anticipate the occurrence of important outcomes. Learning occurs when the actual outcome differs from the predicted outcome, resulting in a prediction error. Neurons in several brain structures appear to code prediction errors in relation to rewards, punishments, external stimuli, and behavioral reactions. In one
Schultz W, Dickinson A
openaire +3 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Prediction error dependent changes in brain connectivity during associative learning [PDF]
, 2009 One of the fundaments of associative learning theories is that surprising events drive learning by signalling the need to update one’s beliefs. It has long been suggested that plasticity of connection strengths between neurons underlies the learning ...
den Ouden, H.E.M.
core
Individual differences in reward-prediction-error: extraversion and feedback-related negativity [PDF]
, 2010 Medial frontal scalp-recorded negativity occurring ∼200–300 ms post-stimulus [known as feedback-related negativity (FRN)] is attenuated following unpredicted reward and potentiated following unpredicted non-reward.
Smillie, Luke D. +5 more
core +1 more source