Results 101 to 110 of about 3,533,074 (286)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Predictive coding in psychopathology: mechanistic model or metaphorical re-description?
Frontiers in Human NeurosciencePredictive coding (PC) has become a central framework in contemporary cognitive neuroscience, proposing that the brain operates as a hierarchical inference system that continuously minimizes the mismatch between predicted and actual sensory input.
Albandri Sultan Alotaibi
doaj +1 more source
Taiwan Journal of Ophthalmology, 2019 PURPOSE: The purpose of this study is to compare the accuracy of new generation formulas to standard formulas for intraocular lens (IOL) power calculations in pediatric patients.
Fouad Raja an-Nakhli
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Optimal classifier selection and negative bias in error rate estimation: An empirical study on high-dimensional prediction [PDF]
, 2009 In biometric practice, researchers often apply a large number of different methods in a "trial-and-error" strategy to get as much as possible out of their data and, due to publication pressure or pressure from the consulting customer, present only the ...
Carolin Strobl +5 more
core +2 more sources
Frontiers in Pain ResearchIntroductionHabituation, or loss of clinical benefit over time, is a frequent problem in spinal cord stimulation (SCS). Existing programming strategies such as waveform cycling or closed-loop stimulation try to address it, but there is no common ...
Alexander Taghva, Alexander Taghva
doaj +1 more source
The Implementation of Predictions During Sequencing
Frontiers in Cellular Neuroscience, 2019 Optimal control mechanisms require prediction capabilities. If one cannot predict the consequences of a motor act or behavior, one will continually collide with walls or become a social pariah.
M. Molinari, M. Masciullo
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Human cerebellum and ventral tegmental area interact during extinction of learned fear
eLifeThe key elements for fear extinction learning are unexpected omissions of expected aversive events, which are considered to be rewarding. Given its reception of reward information, we tested the hypothesis that the cerebellum contributes to reward-like ...
Enzo Nio +13 more
doaj +1 more source
Wait for it: Predicted Error vs. Prediction Error in Language Processing
, 2016 Poster presented at 2015 meeting of the Society for the Neurobiology of ...
Alday, Phillip M. +3 more
openaire +1 more source