Results 91 to 100 of about 6,561,703 (356)

Individual differences in reward-prediction-error: extraversion and feedback-related negativity

, 2010
Medial frontal scalp-recorded negativity occurring ∼200–300 ms post-stimulus [known as feedback-related negativity (FRN)] is attenuated following unpredicted reward and potentiated following unpredicted non-reward.
Smillie, Luke D., Alan D. Pickering, Luke D. Smillie, Andrew J. Cooper, Cooper, Andrew, Pickering, Alan   +5 more
core   +1 more source

Sensory prediction errors predict motor prediction errors

Abstract When sensory inputs can be predicted by an organism’s own actions or external environmental cues, neural activity is often attenuated compared to sensory inputs that are unpredictable. We have recently demonstrated that attenuation to predictable inputs is also observed when stimulating the motor system with transcranial ...
Dominic M. D. Tran, Nicolas A. McNair, Alexis E. Whitton, Thomas J. Whitford, Evan J. Livesey   +4 more
openaire   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Prediction of performance of the DVB-SH system relying on mutual information [PDF]

, 2010
DVB-SH (Digital Video Broadcasting-Satellite Handled) is a broadcasting standard dedicated to hybrid broadcasting systems combining a satellite and a terrestrial part. On the satellite part, dedicated interleaving and time slicing mechanisms are proposed
Chauvet, Wilfried, Amiot-Bazile, Caroline, Lacan, Jérôme, Jerome Lacan, Caroline Amiot-Bazile, Wilfried Chauvet   +5 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Surprise!-Clarifying the link between insight and prediction error. [PDF]

Psychon Bull Rev
The AHA experience, a moment of deep understanding during insightful problem solving involving feelings of certainty, pleasure and surprise, has captivated psychologists for over a century.
Becker M, Wang X, Cabeza R.
europepmc   +2 more sources

Dopamine Modulates Adaptive Prediction Error Coding in the Human Midbrain and Striatum

Journal of Neuroscience, 2017
Learning to optimally predict rewards requires agents to account for fluctuations in reward value. Recent work suggests that individuals can efficiently learn about variable rewards through adaptation of the learning rate, and coding of prediction errors
K. Diederen, H. Ziauddeen, M. Vestergaard, T. Spencer, W. Schultz, P. Fletcher   +5 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Predicting design induced pilot error using HET (human error template) - a new formal human error identification method for flight decks [PDF]

, 2006
Human factors certification criteria are being developed for large civil aircraft with the objective of reducing the incidence of designinduced error on the flight deck.
Harris, Don, Stanton, Neville A., Demagalski, Jason M., Salmon, Paul M., Waldmann, T, Salmon, P M, Salmon, Paul, Dekker, S, Young, MS, Demagalski, J M, Dekker, S. W. A., Salmon, PM, Marshall, A, Dekker, Sidney, Young, Mark S., Harris, D, Dekker, S.W.A., Waldman, T, Demagalski, JM, Stanton, N A, Waldmann, T., Stanton, NA, Marshall, Andrew, Young, M S   +23 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source