Results 101 to 110 of about 3,537,545 (288)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Predictive coding in psychopathology: mechanistic model or metaphorical re-description?
Frontiers in Human NeurosciencePredictive coding (PC) has become a central framework in contemporary cognitive neuroscience, proposing that the brain operates as a hierarchical inference system that continuously minimizes the mismatch between predicted and actual sensory input.
Albandri Sultan Alotaibi
doaj +1 more source
Taiwan Journal of Ophthalmology, 2019 PURPOSE: The purpose of this study is to compare the accuracy of new generation formulas to standard formulas for intraocular lens (IOL) power calculations in pediatric patients.
Fouad Raja an-Nakhli
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Optimal classifier selection and negative bias in error rate estimation: An empirical study on high-dimensional prediction [PDF]
, 2009 In biometric practice, researchers often apply a large number of different methods in a "trial-and-error" strategy to get as much as possible out of their data and, due to publication pressure or pressure from the consulting customer, present only the ...
Carolin Strobl +5 more
core +2 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Frontiers in Pain ResearchIntroductionHabituation, or loss of clinical benefit over time, is a frequent problem in spinal cord stimulation (SCS). Existing programming strategies such as waveform cycling or closed-loop stimulation try to address it, but there is no common ...
Alexander Taghva, Alexander Taghva
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The Implementation of Predictions During Sequencing
Frontiers in Cellular Neuroscience, 2019 Optimal control mechanisms require prediction capabilities. If one cannot predict the consequences of a motor act or behavior, one will continually collide with walls or become a social pariah.
M. Molinari, M. Masciullo
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Human cerebellum and ventral tegmental area interact during extinction of learned fear
eLifeThe key elements for fear extinction learning are unexpected omissions of expected aversive events, which are considered to be rewarding. Given its reception of reward information, we tested the hypothesis that the cerebellum contributes to reward-like ...
Enzo Nio +13 more
doaj +1 more source
Wait for it: Predicted Error vs. Prediction Error in Language Processing
, 2016 Poster presented at 2015 meeting of the Society for the Neurobiology of ...
Alday, Phillip M. +3 more
openaire +1 more source