Results 181 to 190 of about 1,728,519 (315)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A risk prediction model for HPAI outbreaks in Kuwait. [PDF]

Front Vet Sci
Alshatti M, Al-Hemoud A, Othman A, Al-Khalaifah H.   +3 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Development of a Clinical Prediction Model for Recurrent Anaphylaxis. [PDF]

J Clin Med
Uthaisangsook S, Inkate S, Wangchiraniran S.   +2 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A particle swarm optimisation-based Grey prediction model for thermal error compensation on CNC machine tools

, 2015
Thermal errors can have a significant effect on CNC machine tool accuracy. The thermal error compensation system has become a cost-effective method of improving machine tool accuracy in recent years.
Longstaff, Andrew P., Fletcher, Simon, Abdulshahed, Ali, Abdulshahed, Ali M.   +3 more
core  

Validation of a Risk-Prediction Model in the Presence of Outcome Misclassification. [PDF]

Stat Med
Zou R, D Williamson B, M Shortreed S, Coley RY.   +3 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Prediction distribution for linear regression model with multivariate student-t errors

, 2008
The Bayesian approach under uniform prior is employed in this paper to derive the prediction distribution for multiple regression model with multivariate Student-t error distribution.
Rahman, Azizur, Khan, Shahjahan
core  

Clinical Diagnostic Prediction Model For Mycoplasma pneumoniae Pneumonia in Children

Infection and Drug Resistance
Xiaohua Liu,1,* Hongfei Du,2,* Linyan Zhang,1,* Yang Yu,1 Guixiang Wang,1 Fan Zhong,1 Mingjun Zhang,3 Huacui Huang,1 Ying Xu2 1Department of Medical Laboratory, Xindu District People’s Hospital of Chengdu, Chengdu, 610500, People ...
Liu X, Du H, Zhang L, Yu Y, Wang G, Zhong F, Zhang M, Huang H, Xu Y   +8 more
doaj