Results 191 to 200 of about 8,729,244 (299)

Robustness of Protein-Ligand Binding Affinity Prediction Models to Docked and Predicted Structures. [PDF]

J Chem Inf Model
Eaves JN, Woldring DR.
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Comparison of Clinical Characteristics and Pregnancy Outcome Prediction Models Between AIH and AID Patients. [PDF]

Int J Womens Health
Wei H, Huang P, Chen G.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Network Traffic Prediction Using ARIMA and Neural Networks Models

The network traffic prediction plays a fundamental role in network design, management, control and optimization. The self-similar and non-linear nature of traffic makes accurate prediction more difficult.
Rutka, Gundega
core  

Depression and aging: insights from brain age prediction models. [PDF]

Psychol Med
Mitchell O, Connaughton M, Kelly JR, Harkin A, Roddy DW, Aas M.   +5 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

A generalized supervised contrastive learning framework for integrative multi-omics prediction models. [PDF]

Front Microbiomes
Yang S, Wang S, Wang Y, Rong R, Li B, Koh AY, Xiao G, Li Q, Liu D, Zhan X.   +9 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Risk prediction models for post-stroke cognitive impairment: a systematic review and meta-analysis. [PDF]

Front Neurol
Li C, Lv X, Wang X, Xu X, Liu D, Chen X, Dou D, Lin L, Chen L, Huang C, Chen L.   +10 more
europepmc   +1 more source