Results 211 to 220 of about 8,729,244 (299)

Prediction models for progression and outcomes in degenerative cervical myelopathy: a systematic review and critical appraisal. [PDF]

Front Neurol
Zhao R, Xu B, Qin X, Zhang P, Ma G, Wang Z, Yuan D, Li P, Zheng J, Gao Y, Yin H, Yang B, Chen X.   +12 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Critical evaluation of drug response prediction models with DrEval. [PDF]

Nat Commun
Bernett J, Iversen P, Picciani M, Wilhelm M, Baum K, List M.   +5 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

An Online Survey of Healthcare Professionals to Understand the Use of Clinical Prediction Models in Practice

Bunni E, Kingdon C, Bonnett L, Brazier M, Bradley V, Merriel A.   +5 more
europepmc   +1 more source

Separation-like irregularity and sample size optimism in high-discrimination logistic prediction models. [PDF]

PLoS One
Liang Y, Wang LS, Yu J, Zan X.
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Blood biomarker trajectories in ICU-directed prediction models - A scoping review. [PDF]

EPMA J
Von Rekowski CP, Fonseca TAH, Araújo R, Calado CRC, Bento L, Pinto I.   +5 more
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Prediction models for sarcopenia in older adults in China: a scoping review. [PDF]

Front Med (Lausanne)
Yao K, Xu Y, Xu J, Zhang X, Gu F, Hua L, Li X.   +6 more
europepmc   +1 more source