Results 101 to 110 of about 1,850,495 (297)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Individual-Specific Areal-Level Parcellations Improve Functional Connectivity Prediction of Behavior. [PDF]

open access: yesCereb Cortex, 2021
Kong R   +11 more
europepmc   +1 more source

Monte Carlo simulation by computer for life-cycle costing [PDF]

open access: yes, 1969
Prediction of behavior and support requirements during the entire life cycle of a system enables accurate cost estimates by using the Monte Carlo simulation by computer.
Gralow, F. H., Larson, W. J.
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Validation of a novel behavior prediction scale: A two-center trial

open access: yesContemporary Clinical Dentistry, 2014
Context: Prediction of the child′s behavior can adequately equip the dentist in rendering effective and efficient dental treatment. Aim: This study was planned to evaluate and validate a specially prepared questionnaire as a child behavior prediction ...
Sharath Asokan   +4 more
doaj   +1 more source

Deep Interest Evolution Network for Click-Through Rate Prediction

open access: yes, 2018
Click-through rate~(CTR) prediction, whose goal is to estimate the probability of the user clicks, has become one of the core tasks in advertising systems.
Bian, Weijie   +7 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Automated drowsiness detection for improved driving safety [PDF]

open access: yes, 2008
Several approaches were proposed for the detection and prediction of drowsiness. The approaches can be categorized as estimating the fitness of duty, modeling the sleep-wake rhythms, measuring the vehicle based performance and online operator monitoring ...
Bartlett, Marian   +7 more
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

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