Results 41 to 50 of about 827,518 (265)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Prediction of Vehicle Crashworthiness Parameters Using Piecewise Lumped Parameters and Finite Element Models

Designs, 2018
Estimating the vehicle crashworthiness experimentally is expensive and time-consuming. For these reasons, different modelling approaches are utilised to predict the vehicle behaviour and reduce the need for full-scale crash testing. The earlier numerical
Bernard B. Munyazikwiye, Dmitry Vysochinskiy, Mikhail Khadyko, Kjell G. Robbersmyr   +3 more
doaj   +1 more source

Improving Reliability of Prediction Results of Mine Surface Subsidence of Northern Pei County for Reusing Land Resources

Applied Sciences, 2020
The accurate prediction of mine surface subsidence is directly related to the reuse area of land resources. Currently, the probability integral method is the most extensive method of surface subsidence prediction in China.
Yafei Yuan, Huaizhan Li, Haojie Zhang, Yiwei Zhang, Xuewei Zhang   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Analysis of Mining Subsidence Characteristics and Deformation Prediction considering Size Parameters and Mechanical Parameters

Geofluids, 2022
Crushing and caving of roof strata in goaf is an important factor affecting surface subsidence. In order to study the influence law of mining under thick loose layer, overburden size parameters, and initial mechanical parameters of collapse zone on ...
Shangguo Liu, Kaixin Li, Weiping Shi, Zijun Wang, Haoran Zhang, Zhaoying Li   +5 more
doaj   +1 more source

Stochastic parameter prediction in cardiovascular problems

Computer Methods in Biomechanics and Biomedical Engineering
Patient-specific modeling of cardiovascular flows with high-fidelity is challenging due to its dependence on accurately estimated velocity boundary profiles, which are essential for precise simulations and directly influence wall shear stress calculations - key in predicting cardiovascular diseases like atherosclerosis. This data, often derived from in
Bakhshaei, Kabir, Salavatidezfouli, Sajad, Stabile, Giovanni, Rozza, Gianluigi   +3 more
openaire   +4 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Model predictions for neutrino oscillation parameters [PDF]

Physical Review D, 2006
We have surveyed leptonic and grand unified models of neutrino masses and mixings in the literature which are still viable and give numerical predictions for the reactor angle, $θ_{13}$. The results are of considerable interest in anticipation of the next generation reactor experiments and the possible future need for neutrino factories.
Albright, Carl, Chen, Mu-Chun, Albright, Carl, Chen, Mu-Chun   +3 more
openaire   +3 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source