Results 71 to 80 of about 785,552 (265)

Research on hydraulic support column load prediction method based on extended multi-parameters

open access: yesGong-kuang zidonghua
In order to establish the mapping relationship between the hydraulic support column load and its dynamic response characteristics, and to realize dynamic prediction of the column load, a hydraulic support column load prediction method based on extended ...
WANG Yunfei   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

The Accuracy of Dynamic Parameters for Prediction of Fluid Responsiveness in Elderly Patients with Septic Shock

open access: yesInternational Journal of General Medicine
Sittikorn Paphawin,1,* Pongdhep Theerawit,2,* Detajin Junhasavasdikul,3 Yuda Sutherasan3 1Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Division of Critical Care Medicine, Department of ...
Paphawin S   +3 more
doaj  

The development of methods for rapid prediction of frost resistance of ceramic products/Keraminių gaminių atsparumo šalčiui sparčiųjų prognozavimo metodų raida

open access: yesJournal of Civil Engineering and Management, 1999
One of important parameters determining the quality of ceramic products is the resistance to frost. Frost resistance of ceramic brick can be determined exactly by direct unilateral freezing methods.
Asta Kičaitė
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

On prediction accuracy of neutronics parameters of accelerator-driven system

open access: yesEPJ Web of Conferences, 2017
Nuclear data-induced uncertainty of neutronics parameters of one specific ADS design is quantified. The nuclear data adjustment method with available integral data is employed to reduce the uncertainties, and usefulness of these integral data is ...
Chiba Go   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Prediction of Hypertension Based on Anthropometric Parameters in Adolescents in Eastern Sudan: A Community-Based Study

open access: yesVascular Health and Risk Management
Awab H Saad,1 Ahmed A Hassan,2 Abdullah Al-Nafeesah,3 Ashwaq AlEed,3 Ishag Adam4 1Department of Medicine, Faculty of Medicine, Gadarif University, Gadarif, 32211, Sudan; 2Department of Medicine, Faculty of Medicine, University of Khartoum, Khartoum ...
Saad AH   +4 more
doaj  

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