Results 71 to 80 of about 785,552 (265)
Research on hydraulic support column load prediction method based on extended multi-parameters
In order to establish the mapping relationship between the hydraulic support column load and its dynamic response characteristics, and to realize dynamic prediction of the column load, a hydraulic support column load prediction method based on extended ...
WANG Yunfei +4 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Sittikorn Paphawin,1,* Pongdhep Theerawit,2,* Detajin Junhasavasdikul,3 Yuda Sutherasan3 1Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Division of Critical Care Medicine, Department of ...
Paphawin S +3 more
doaj
One of important parameters determining the quality of ceramic products is the resistance to frost. Frost resistance of ceramic brick can be determined exactly by direct unilateral freezing methods.
Asta Kičaitė
doaj +1 more source
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
On prediction accuracy of neutronics parameters of accelerator-driven system
Nuclear data-induced uncertainty of neutronics parameters of one specific ADS design is quantified. The nuclear data adjustment method with available integral data is employed to reduce the uncertainties, and usefulness of these integral data is ...
Chiba Go +3 more
doaj +1 more source
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Awab H Saad,1 Ahmed A Hassan,2 Abdullah Al-Nafeesah,3 Ashwaq AlEed,3 Ishag Adam4 1Department of Medicine, Faculty of Medicine, Gadarif University, Gadarif, 32211, Sudan; 2Department of Medicine, Faculty of Medicine, University of Khartoum, Khartoum ...
Saad AH +4 more
doaj

