Results 121 to 130 of about 2,497,925 (305)
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
TabSieve: Explicit In-Table Evidence Selection for Tabular Prediction
CoRRTabular prediction can benefit from in-table rows as few-shot evidence, yet existing tabular models typically perform instance-wise inference and LLM-based prompting is often brittle. Models do not consistently leverage relevant rows, and noisy context can degrade performance.
Yongyao Wang +6 more
openaire +2 more sources
Multi-period credit default prediction with time-varying covariates [PDF]
In credit default prediction models, the need to deal with time-varying covariates often arises. For instance, in the context of corporate default prediction a typical approach is to estimate a hazard model by regressing the hazard rate on time-varying ...
Orth, Walter
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Modelling decision tables from data. [PDF]
On most datasets induction algorithms can generate very accurate classifiers. Sometimes, however, these classifiers are very hard to understand for humans. Therefore, in this paper it is investigated how we can present the extracted knowledge to the user
Vanthienen, Jan, Wets, G, Timmermans, H
core
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Retrieve, Merge, Predict: Augmenting Tables with Data Lakes
CoRR12 pages + references, 5 figures in main body.
Cappuzzo, Riccardo +4 more
openaire +4 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Representing fuzzy decision tables in a fuzzy relational database environment. [PDF]
In this paper the representation of decision tables in a relational database environment is discussed. First, crisp decision tables are defined. Afterwards a technique to represent decision tables in a relational system is presented.
Vanthienen, Jan, Wets, G, Chen, G
core