Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Tide tables, United States and foreign ports /
, 1921 Vol. for 1922 includes Data on currents.Vol. for 1922 includes Data on currents.Mode of access: Internet.Issued by the U.S. Coast and Geodetic Survey.Continues: General tide tables for the year .
U.S. Coast and Geodetic Survey.
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Provincial Input-Output Tables, Level S, W: Other, 2009-2011 [Canada]
Provincial Input-Output Tables (15F0042XDB) The Input-Output accounting system consists of three tables. The input tables (USE tables) detail the commodities that are consumed by various industries.
Statistics Canada
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Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
, 2011 Conference Name:2011 International Conference on Wavelet Analysis and Pattern Recognition, ICWAPR 2011. Conference Address: Guilin, Guangxi, China. Time:July 10, 2011 - July 13, 2011.Hebei University; IEEE Systems, Man and Cybernetics Society; Chongqing ...
Gao, Zong-Chang +2 more
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Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Limited External Validation and Uncertain Clinical Utility of Prediction Models for Bacteriologically Negative Pulmonary Tuberculosis: A Systematic Review. [PDF]
CureusZhai C +6 more
europepmc +1 more source
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
SizeResGraph-Guided GFN2-xTB Screening of Low-Gap Thiophene-Containing Polymer Repeat Units. [PDF]
ACS OmegaShi B, Zhang S, Wu J, Fang J, Yang J.
europepmc +1 more source