Results 101 to 110 of about 1,720,482 (294)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Delirium prediction in the intensive care unit: comparison of two delirium prediction models

Critical Care, 2018
Background Accurate prediction of delirium in the intensive care unit (ICU) may facilitate efficient use of early preventive strategies and stratification of ICU patients by delirium risk in clinical research, but the optimal delirium prediction model to
Annelies Wassenaar, Lisette Schoonhoven, John W. Devlin, Frank M. P. van Haren, Arjen J. C. Slooter, Philippe G. Jorens, Mathieu van der Jagt, Koen S. Simons, Ingrid Egerod, Lisa D. Burry, Albertus Beishuizen, Joaquim Matos, A. Rogier T. Donders, Peter Pickkers, Mark van den Boogaard   +14 more
doaj   +1 more source

To predict and to manage. Predictive policing in the United States [PDF]

Big Data & Society, 2019
This article offers a detailed examination of the content of predictive policing applications. Crime prediction machines are used by governments to shape the moral behavior of police. They serve not only to predict when and where crime is likely to occur, but also to regulate police work. They calculate equivalence ratios, distributing security across
openaire   +3 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Growing pains with kratom: experiences discussed in subreddits contrast with satisfaction expressed in surveys

Frontiers in Pharmacology
Background“Kratom” refers to an array of bioactive products derived from Mitragyna speciosa, a tree indigenous to Southeast Asia. Most kratom consumers report analgesic and stimulatory effects, and common reasons for use are to address mental and ...
Jeffrey M. Rogers, Kayla Colvin, David H. Epstein, Oliver Grundmann, Christopher R. McCurdy, Kirsten E. Smith   +5 more
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Autonomous UAV Safety Oriented Situation Monitoring and Evaluation System

Drones
In this paper, a LabVIEW-based online monitoring and safety evaluation system for UAVs is designed to address the deficiencies in UAV flight state parameter monitoring and safety evaluation.
Zhuoyong Shi, Jiandong Zhang, Guoqing Shi, Mengjie Zhu, Longmeng Ji, Yong Wu   +5 more
doaj   +1 more source

Determination of the distribution of sound source intensities in subsonic and supersonic jets [PDF]

Equations relating crossed beam space-time correlations to the sound source strength per unit length of an idealized jet are presented and applied to actual measurements in unheated jets at M = 0.71 and M = 1.0.
Damkevala, R. J., Norman, R. S.
core   +1 more source