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Transient Sensorineural Hearing Loss and Rhabdomyolysis, Associated With Chronic Kratom Use. [PDF]

Case Rep Otolaryngol
Kratom is a colloquial name for products derived from the mitragyna plant species originating in Southeast Asia and now widely available in the United States as a dietary supplement. Kratom is used primarily for self‐management of pain, anxiety, and opioid withdrawal due to its partial agonist activity on mu opioid receptors, as well as other ...
Watanabe H, Zhang K, Shapiro Y.
europepmc   +2 more sources

Commentary on Comstock et al.: Here we go again-Kratom and the failure to learn from the opioid crisis. [PDF]

Addiction
Addiction, Volume 121, Issue 9, Page 2468-2469, September 2026.
Kolodny A.
europepmc   +2 more sources

Serotonin release mediates analgesia via opioidergic system and withdrawal symptoms in chronic kratom extract-treated mice

BMC Complementary Medicine and Therapies
Background Kratom alleviates pain by activating μu-opioid receptors (MOR), which trigger serotonin release to produce analgesia. Serotonin also interferes drug abuse effect.
Dwi Wahyu Indriani, Siti Irma Rahmawati, Asep Bayu, Peni Ahmadi, Anissa Nofita Sari, Zuraida Zuraida, Ni Luh Putu Indi Dharmayanti, Masteria Yunovilsa Putra   +7 more
doaj   +2 more sources

Kratom safety and toxicology in the public health context: research needs to better inform regulation

Frontiers in Pharmacology
Although kratom use has been part of life for centuries in Southeast Asia, the availability and use of kratom in the United States (US) increased substantially since the early 2000s when there was little information on kratom pharmacology, use patterns ...
Jack E. Henningfield, Jack E. Henningfield, Oliver Grundmann, Marilyn A. Huestis, Kirsten E. Smith   +4 more
doaj   +2 more sources

Assessment of Abuse Potential-Related Effects of Oral Dried Kratom Leaf Powder in Healthy Normal Participants Following Single and Multiple Daily Doses. [PDF]

Drug Test Anal
In a randomized, double‐blind, placebo‐controlled study of oral dried kratom leaf powder in healthy kratom‐naive adults, no participants met the clinically meaningful opioid withdrawal threshold; abuse‐related treatment‐emergent adverse events occurred more frequently at higher doses but were generally mild and resolved without sequelae; and no serious
Coe M, Huestis M, Wang D, Hudzik T, Bothmer J, Henningfield J.   +5 more
europepmc   +2 more sources

Kratom use among ethnobotanical tea bar patrons in Colorado: Subjective drug effects, adverse reactions, and perceived benefits of use

Drug and Alcohol Dependence Reports
Introduction: Kratom use is increasing in the US, yet data characterizing use patterns, risks, and benefits is limited. Additionally, there are few data on the acute subjective effects of kratom in humans, and no studies to-date have examined kratom use ...
Cianna J. Piercey, Joseph Bunch, Joseph Cameron, Riley Ahern, Isabella Packwood, Carter Bruning, Devin Henry, Jesse Ruehrmund, Katelyn Weldon, Kirsten E. Smith, Hollis C. Karoly   +10 more
doaj   +2 more sources

Kratom Cardiotoxicity

JACC: Case Reports
Kratom is derived from Mitragyna speciosa and contains active alkaloids that bind opioid, alpha-2 adrenergic, and 5-HT2A receptors. In vitro studies show kratom can inhibit myocardial potassium channels. We present a patient who developed a reversible Brugada pattern and QT prolongation after self-treating his attention-deficit/hyperactivity disorder ...
Andrew H.F. Miller, Alex J. Krotulski, Sara E. Walton, Anna R. Dulaney, Aaron P. Frolichstein, Haley L. Dusek, Christine Murphy   +6 more
openaire   +3 more sources

Characteristics of adverse reactions to kratom and implementation of harm reduction strategies in a sample of ethnobotanical tea bar patrons in Colorado [PDF]

Harm Reduction Journal
Background Kratom is a psychoactive botanical that is increasingly popular in the United States. While potential risks of kratom use have been identified, research on harm reduction strategies and contextual factors contributing to adverse reactions is ...
Cianna J. Piercey, Joseph Cameron, Riley Ahern, Isabella Packwood, Carter Bruning, Devin Henry, Jesse Ruehrmund, Katelyn Weldon, Kirsten E. Smith, Hollis C. Karoly   +9 more
doaj   +2 more sources

Kratom leaf extracts exert hypolipidaemic effects via the modulation of PCSK9 and LDLR pathways in HepG2 cells

Scientific Reports
Kratom (Mitragyna speciosa (Korth.) Havil.) has been reported to reduce serum lipids. However, the molecular mechanism underlying hypolipidaemic effect of kratom is still unclear.
Nantiya Nawaka, Monthon Lertcanawanichakul, Sureerut Porntadavity, Burabha Pussadhamma, Nutjaree Jeenduang   +4 more
doaj   +2 more sources

Reported associations between kratom and seizures: a systematic review

Frontiers in Pharmacology
Statement of purpose, innovation or hypothesisKratom, derived from the leaves of the plant Mitragyna speciosa, is an herbal supplement that has been used medically and recreationally for centuries, but has recently gained popularity in the United States ...
Toby Turla, Grayson Abele, My Hua, Dennis Paustenbach   +3 more
doaj   +2 more sources