Results 1 to 10 of about 9,834 (169)

A Chromosome-Scale Genome Assembly of Mitragyna speciosa (Kratom) and the Assessment of Its Genetic Diversity in Thailand [PDF]

Biology, 2022
Mitragyna speciosa (Kratom) is a tropical narcotic plant native to Southeast Asia with unique pharmacological properties. Here, we report the first chromosome-scale assembly of the M. speciosa genome. We employed PacBio sequencing to obtain a preliminary
Wirulda Pootakham, Thippawan Yoocha, Nukoon Jomchai, Wasitthee Kongkachana, Chaiwat Naktang, Chutima Sonthirod, Srimek Chowpongpang, Panyavut Aumpuchin, Sithichoke Tangphatsornruang   +8 more
doaj   +3 more sources

Comparative metabolomics analysis reveals alkaloid repertoires in young and mature Mitragyna speciosa (Korth.) Havil. Leaves. [PDF]

PLoS ONE, 2023
The fresh leaves of Mitragyna speciosa (Korth.) Havil. have been traditionally consumed for centuries in Southeast Asia for its healing properties. Although the alkaloids of M.
Rubashiny Veeramohan, Arief Izzairy Zamani, Kamalrul Azlan Azizan, Hoe-Han Goh, Wan Mohd Aizat, Mohd Fauzi Abd Razak, Nur Sabrina Mohd Yusof, Sharif Mahsufi Mansor, Syarul Nataqain Baharum, Chyan Leong Ng   +9 more
doaj   +3 more sources

In Vitro and in Vivo Effects of Three Different Mitragyna speciosa Korth Leaf Extracts on Phase II Drug Metabolizing Enzymes—Glutathione Transferases (GSTs)

Molecules, 2010
In the present study, we investigate the effects of three different Mitragyna speciosa extracts, namely methanolic, aqueous and total alkaloid extracts, on glutathione transferase-specific activity in male Sprague Dawley rat liver cytosol in vitro and in
Mohd Nizam Mordi, Juzaili Azizi, Surash Ramanathan   +2 more
exaly   +4 more sources

Effect of Oral Supplementation of Kratom (Mitragyna speciosa Korth.) on Gastrointestinal Nematodes and Serum Lipid Peroxidation in Crossbred Saanen Goats [PDF]

Veterinary Sciences
The objective of this study was to compare fecal egg count (FEC) and serum malondialdehyde (MDA) concentration in naturally parasite-infected goats following administration of an anthelmintic drug and Mitragyna speciosa Korth.
Sopon Veerapan, Supawit Triwutanon, Theera Rukkwamsuk   +2 more
doaj   +2 more sources

Phytochemical profile and chemosensitizing anticancer activity of Mitragyna speciosa and mitragynine [PDF]

Scientific Reports
This study examined the phytochemical composition, antioxidant efficacy, and cytotoxic properties of Mitragyna speciosa (kratom) extracts and its principal alkaloid, mitragynine.
Panita Kongsila, Thidarut Boonmars, Pranee Sriraj, Jatuporn Prathumtet, Praphat Manuelo Ruengthanoo, Ratchadawan Aukkanimart   +5 more
doaj   +2 more sources

A novel approach for wound treatment using Mitragyna speciosa-encapsulated nanostructured lipid carriers in hydrogel film [PDF]

Journal of Advanced Pharmaceutical Technology & Research
Adequate wound healing is important for re-establishing the normal skin function. Determining the most suitable therapeutic strategy for skin repair involves multiple considerations, including wound type and condition, injury severity, lesion extent, and
Anan Khadijah Imani Zulkifli, Siti Efliza Ashari, Syahida Ahmad, Masriana Hassan, Razana Mohd Ali   +4 more
doaj   +2 more sources

Evaluation of Antioxidant and Antibacterial Activities of Aqueous, Methanolic and Alkaloid Extracts From Mitragyna speciosa (Rubiaceae Family) Leaves

Molecules, 2009
Studies on the antioxidant and antimicrobial activities of Mitragyna speciosa leaf extracts are lacking. In this study the antioxidant properties of water, methanolic and alkaloid M.
Sreenivasan Sasidharan, Suhanya Parthasarathy, Surash Ramanathan   +2 more
exaly   +3 more sources

Association between kratom (Mitragyna speciosa) use and metabolic syndrome [PDF]

Heliyon, 2022
Background and aims: There are evidence about effects of kratom (Mitragyna speciosa) use on parameters related to metabolic syndrome (MetS). The present study aimed to determine the association between kratom use and MetS.
Aroon La-up, Paleeratana Wongrith, Wiraphon Chaichan, Apinun Aramrattana, Udomsak Saengow   +4 more
doaj   +2 more sources

Mitragyna speciosa Korth toxicity: Experimental findings and future prospects [PDF]

Journal of Taibah University Medical Sciences
الملخص: أهداف البحث: نبات القرطوم، المعروف علميا باسم ميتراجينا سبيسيوزا، هو نبات طبي تقليدي من جنوب شرق آسيا، يحتوي على قلويد الميتراجينين كمركب رئيسي. ومثل النباتات الطبية الأخرى، له آثار جانبية وتأثيرات سمية موثقة في الدراسات العلمية وتقارير الحالات.
Taslima Begum, MSc, Mohd H. Arzmi, PhD, A.B.M. Helal Uddin, PhD, Alfi Khatib, PhD, Syed A. Abbas, PhD, Qamar U. Ahmed, PhD   +5 more
doaj   +2 more sources

Mitragyna speciosa: Clinical, Toxicological Aspects and Analysis in Biological and Non-Biological Samples

Medicines (Basel, Switzerland), 2019
The abuse of psychotropic substances is a well-known phenomenon, and many of them are usually associated with ancestral traditions and home remedies. This is the case of Mitragyna speciosa (kratom), a tropical tree used to improve work performance and to
Joana Domingos Goncalves, Mário Barroso, Eugenia Gallardo   +2 more
exaly   +3 more sources