Phytochemical profile and chemosensitizing anticancer activity of Mitragyna speciosa and mitragynine [PDF]
Scientific ReportsThis study examined the phytochemical composition, antioxidant efficacy, and cytotoxic properties of Mitragyna speciosa (kratom) extracts and its principal alkaloid, mitragynine.
Panita Kongsila +5 more
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Mapping partial agonism of mitragynine at the µ-opioid receptor through molecular dynamics and Markov state modelling analysis [PDF]
Scientific ReportsMitragynine, a major indole alkaloid from Mitragyna speciosa (kratom), acts as a partial agonist at the µ-opioid receptor (µOR), yet the structural basis for its submaximal efficacy remains unclear. Here, we integrate microsecond-scale all-atom molecular
Mohammad Nazri Abdul Bahari +6 more
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Optimizing the Soil Calcium:Magnesium Ratio Improves the Mitragynine Yield and Seedling Growth in Kratom (Mitragyna speciosa) [PDF]
PlantsThis study investigates how soil calcium (Ca) and magnesium (Mg) supplementation influence mitragynine accumulation in Mitragyna speciosa (kratom), addressing the lack of quantitative thresholds in previous research.
Nisa Leksungnoen +8 more
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DNA Barcoding and Chemical Profile Using UHPLC, GC-MS and LC-MS/QTOF of Mitragyna speciosa Variation and Allied Species for Quality Control of Kratom Materials [PDF]
PlantsKratom (Mitragyna speciosa Korth.) has gained increasing global attention due to its traditional use, psychoactive properties, and emerging therapeutic potential; however, concerns regarding adulteration, substitution, and inconsistent quality of ...
Phunsuk Anantaworasakul +11 more
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Journal of Pharmaceutical Sciences, 1974 Microbial transformation of the alkaloid mitragynine by the fungus Helminthosporum sp. has elaborated two major metabolites. The compounds were isolated from the biological milieu and their structures were elucidated as mitragynine pseudoindoxyl and hydroxy mitragynine pseudoindoxyl.
J E Zarembo, Jerry A Weisbach
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Bayesian inference for integrated pharmacokinetic modelling of mitragynine and 7-hydroxymitragynine [PDF]
ADMET and DMPKBackground and purpose: Mitragynine is an active compound in kratom that is metabolized to the pharmacologically active 7-hydroxymitragynine, requiring an integrated pharmacokinetic approach to maintain plasma concentrations of both within the optimal ...
Dion Notario +4 more
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Unravelling Rational Design of Molecularly Imprinted Polymer for Selective Mitragynine Isolation from Kratom: Quantum Mechanical, Molecular Dynamics, and Experimental Insights [PDF]
MoleculesMitragyna speciosa, commonly referred to as kratom, is known for its active compound, mitragynine, which is classified as a new psychoactive substance. The availability of mitragynine standards remains a challenge, highlighting the need for effective and
Untung Gunawan +8 more
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Molecules, 2015 Varied pharmacological responses have been reported for mitragynine in the literature, but no supportive scientific explanations have been given for this.
Surash Ramanathan +2 more
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Cosmeceutical Potential of Mitragyna speciosa (Kratom): Anti-Adipogenic and Antioxidant Properties of Extracts and Mitragynine [PDF]
MoleculesKratom (Mitragyna speciosa (Korth.) Havil.) is a medicinal plant containing bioactive alkaloids, notably mitragynine and 7-hydroxymitragynine, which are psychoactive compounds with analgesic and stimulant properties.
Sudthiworarak Kaewchompoo +5 more
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In silico investigation of mitragynine and 7-hydroxymitragynine metabolism [PDF]
BMC Research Notes, 2019 Objective Mitragynine is the main active compound of Mitragyna speciose (Kratom in Thai). The understanding of mitragynine derivative metabolism in human body is required to develop effective detection techniques in case of drug abuse or establish an ...
Taweetham Limpanuparb +2 more
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