Results 1 to 10 of about 1,701 (157)

Human Mitragynine and 7-Hydroxymitragynine Pharmacokinetics after Single and Multiple Daily Doses of Oral Encapsulated Dried Kratom Leaf Powder [PDF]

Molecules
Kratom leaves, consumed by millions worldwide as tea or ground leaf powder, contain multiple alkaloids, with mitragynine being the most abundant and responsible for most effects.
Martin Brett, Marilyn Huestis
exaly   +5 more sources

Understanding the Physicochemical Properties of Mitragynine, a Principal Alkaloid of Mitragyna speciosa, for Preclinical Evaluation

Molecules, 2015
Varied pharmacological responses have been reported for mitragynine in the literature, but no supportive scientific explanations have been given for this.
Vikneswaran Murugaiyah, Suhanya Parthasarathy, Surash Ramanathan   +2 more
exaly   +4 more sources

Simultaneous quantification of seventeen kratom alkaloids and metabolites in human plasma and its application to clinical pharmacokinetic sample analysis [PDF]

Pharmaceutical Biology
Context Mitragyna speciosa Korth, commonly known as kratom, has been used traditionally in Southeast Asia by chewing fresh leaves and brewing decoctions (tea) for its stimulant and sedative-like properties. Despite its widespread use, controlled clinical
Siva Rama Raju Kanumuri, Manoj Gundeti, Sushobhan Mukhopadhyay, Naftali Z. Zeilinger, C. Austin Zamarripa, Kirsten E. Smith, Christopher R. McCurdy, Abhisheak Sharma   +7 more
doaj   +2 more sources

Multifunctional Bacterial Cellulose Films Incorporating Kratom (Mitragyna speciosa Korth.) Leaf Extract as a Preliminary Antibacterial and Cytocompatible Wound Dressing Candidate [PDF]

Nanomaterials
Leaves of Mitragyna speciosa Korth. (M. speciosa), commonly known as Kratom, are rich in alkaloids, with mitragynine as the main bioactive compound. This study presents a technique for the entrapment of ethanolic Kratom leaf extract within bacterial ...
Arnon Khamkeaw, Suwaphit Thaksin, Thitiwan Pechsiri, Phasuwit P. Phatchayawat, Suchada Sukrong, Suttinun Phongtamrug, Muenduen Phisalaphong   +6 more
doaj   +2 more sources

Phytochemical profile and chemosensitizing anticancer activity of Mitragyna speciosa and mitragynine [PDF]

Scientific Reports
This study examined the phytochemical composition, antioxidant efficacy, and cytotoxic properties of Mitragyna speciosa (kratom) extracts and its principal alkaloid, mitragynine.
Panita Kongsila, Thidarut Boonmars, Pranee Sriraj, Jatuporn Prathumtet, Praphat Manuelo Ruengthanoo, Ratchadawan Aukkanimart   +5 more
doaj   +2 more sources

Mapping partial agonism of mitragynine at the µ-opioid receptor through molecular dynamics and Markov state modelling analysis [PDF]

Scientific Reports
Mitragynine, a major indole alkaloid from Mitragyna speciosa (kratom), acts as a partial agonist at the µ-opioid receptor (µOR), yet the structural basis for its submaximal efficacy remains unclear. Here, we integrate microsecond-scale all-atom molecular
Mohammad Nazri Abdul Bahari, Liyana Azmi, Low Chen Fei, Amir Syahir, Enoch Perimal, Asrulnizam Abd Manaf, Muhamad Arif Mohamad Jamali   +6 more
doaj   +2 more sources

Optimizing the Soil Calcium:Magnesium Ratio Improves the Mitragynine Yield and Seedling Growth in Kratom (Mitragyna speciosa) [PDF]

Plants
This study investigates how soil calcium (Ca) and magnesium (Mg) supplementation influence mitragynine accumulation in Mitragyna speciosa (kratom), addressing the lack of quantitative thresholds in previous research.
Nisa Leksungnoen, Tushar Andriyas, Yongkriat Ku-Or, Suthaporn Chongdi, Pichaya Pongchaidacha, Chatchai Ngernsaengsaruay, Suwimon Uthairatsamee, Rossarin Tansawat, Kanjananat Boondum   +8 more
doaj   +2 more sources

DNA Barcoding and Chemical Profile Using UHPLC, GC-MS and LC-MS/QTOF of Mitragyna speciosa Variation and Allied Species for Quality Control of Kratom Materials [PDF]

Plants
Kratom (Mitragyna speciosa Korth.) has gained increasing global attention due to its traditional use, psychoactive properties, and emerging therapeutic potential; however, concerns regarding adulteration, substitution, and inconsistent quality of ...
Phunsuk Anantaworasakul, Warunya Arunotayanun, Siripat Chaichit, Suthiwat Khamnuan, Chatchai Ngernsaengsaruay, Chuda Chittasupho, Nisa Leksungnoen, Mingkwan Na Takuathung, Ruedeemars Yubolphan, Apisada Jiso, Tachpon Techarang, Aekkhaluck Intharuksa   +11 more
doaj   +2 more sources

Bayesian inference for integrated pharmacokinetic modelling of mitragynine and 7-hydroxymitragynine [PDF]

ADMET and DMPK
Background and purpose: Mitragynine is an active compound in kratom that is metabolized to the pharmacologically active 7-hydroxymitragynine, requiring an integrated pharmacokinetic approach to maintain plasma concentrations of both within the optimal ...
Dion Notario, Untung Gunawan, Pretty Falena Atmanda Kambira, Erna Wulandari, Eko Adi Prasetyanto   +4 more
doaj   +2 more sources

Unravelling Rational Design of Molecularly Imprinted Polymer for Selective Mitragynine Isolation from Kratom: Quantum Mechanical, Molecular Dynamics, and Experimental Insights [PDF]

Molecules
Mitragyna speciosa, commonly referred to as kratom, is known for its active compound, mitragynine, which is classified as a new psychoactive substance. The availability of mitragynine standards remains a challenge, highlighting the need for effective and
Untung Gunawan, Eko Adi Prasetyanto, Pretty Falena Atmanda Kambira, Dion Notario, Erna Wulandari, Enade Perdana Istyastono, Andrea Tirta Wening, Kellie Irlianto, Atthar Luqman Ivansyah   +8 more
doaj   +2 more sources