Results 11 to 20 of about 1,701 (157)

Methadone, Buprenorphine, and Clonidine Attenuate Mitragynine Withdrawal in Rats [PDF]

Frontiers in Pharmacology, 2021
Background: Kratom or Mitragyna speciosa Korth has been widely used to relieve the severity of opioid withdrawal in natural settings. However, several studies have reported that kratom may by itself cause dependence following chronic consumption.
Rahimah Hassan, Sasidharan Sreenivasan, Christian P. Müller, Christian P. Müller, Zurina Hassan, Zurina Hassan   +5 more
doaj   +2 more sources

Comparison of Extraction Variations on Mitragynine Level of Three Variants of Kratom Leaves (Mitragyna speciosa Korth) [PDF]

EduChemia, 2023
Kratom leaves are known as traditional medicine with various benefits, such as antibacterial, antimicrobial, and antioxidant properties. These benefits are attributed to the presence of secondary metabolites, particularly mitragynine.
Syrifah Nur Intan Mutiara, Masriani Masriani, Rini Muharini, Ajuk Sapar, Rahmat Rasmawan   +4 more
doaj   +2 more sources

Cosmeceutical Potential of Mitragyna speciosa (Kratom): Anti-Adipogenic and Antioxidant Properties of Extracts and Mitragynine [PDF]

Molecules
Kratom (Mitragyna speciosa (Korth.) Havil.) is a medicinal plant containing bioactive alkaloids, notably mitragynine and 7-hydroxymitragynine, which are psychoactive compounds with analgesic and stimulant properties.
Sudthiworarak Kaewchompoo, Prapapan Temkitthawon, Kalyarut Phumlek, Neti Waranuch, Ngamrayu Ngamdokmai, Kornkanok Ingkaninan   +5 more
doaj   +2 more sources

Oral administration of kratom leaf extract alleviates anxiety-like behavior, urinary bladder pain, voiding dysfunction, and bladder hypercontractility via attenuating muscarinic receptor response in male mice exposed to chronic water avoidance stress [PDF]

Frontiers in Neuroscience
Psychological stress causes and deteriorates interstitial cystitis/painful bladder syndrome with urinary frequency, incontinence, bladder pain and urgency.
Sarunnuch Sattayachiti, Panida Chumpong, Dania Cheaha, Dania Cheaha, Nattapon Rotpenpian, Ekkasit Kumarnsit, Ekkasit Kumarnsit, Nipaporn Konthapakdee   +7 more
doaj   +2 more sources

Assessment of Abuse Potential-Related Effects of Oral Dried Kratom Leaf Powder in Healthy Normal Participants Following Single and Multiple Daily Doses. [PDF]

Drug Test Anal
In a randomized, double‐blind, placebo‐controlled study of oral dried kratom leaf powder in healthy kratom‐naive adults, no participants met the clinically meaningful opioid withdrawal threshold; abuse‐related treatment‐emergent adverse events occurred more frequently at higher doses but were generally mild and resolved without sequelae; and no serious
Coe M, Huestis M, Wang D, Hudzik T, Bothmer J, Henningfield J.   +5 more
europepmc   +2 more sources

The respiratory depressant effects of mitragynine are limited by its conversion to 7-OH mitragynine [PDF]

, 2022
Background and Purpose: Mitragynine, the major alkaloid in Mitragyna speciosa (kratom), is a partial agonist at the μ opioid receptor. CYP3A-dependent oxidation of mitragynine yields the metabolite 7-OH mitragynine, a more efficacious μ receptor agonist.
Canals, Meritxell, J. Robert Lane, Hill, Rob, Lane, J. Robert, Meritxell Canals, Jonathan A. Javitch, Javitch, Jonathan A., Rob Hill, Kruegel, Andrew C., Andrew C. Kruegel   +9 more
core   +1 more source

Adolescent kratom exposure affects cognitive behaviours and brain metabolite profiles in Sprague-Dawley rats

Frontiers in Pharmacology, 2022
Adolescence is a critical developmental period during which exposure to psychoactive substances like kratom (Mitragyna speciosa) can cause long-lasting deleterious effects.
Aiman Nadhirah Zul Aznal, Nurul Aqmar Mohamad Nor Hazalin, Zurina Hassan, Noorul Hamizah Mat, Nelson Jeng-Yeou Chear, Lay Kek Teh, Mohd Zaki Salleh, Farah Wahida Suhaimi   +7 more
doaj   +1 more source

The Chemical and Pharmacological Properties of Mitragynine and Its Diastereomers: An Insight Review

Frontiers in Pharmacology, 2022
Mitragynine, is a naturally occurring indole alkaloid that can be isolated from the leaves of a psychoactive medicinal plant. Mitragyna speciosa, also known as kratom, is found to possess promising analgesic effects on mediating the opioid receptors such
Thiruventhan Karunakaran, Thiruventhan Karunakaran, Kok Zhuo Ngew, Kok Zhuo Ngew, Ahmad Alif Danial Zailan, Vivien Yi Mian Jong, Mohamad Hafizi Abu Bakar   +6 more
doaj   +1 more source

Evaluation of the cardiotoxicity of mitragynine and its analogues using human induced pluripotent stem cell-derived cardiomyocytes. [PDF]

PLoS ONE, 2014
INTRODUCTION:Mitragynine is a major bioactive compound of Kratom, which is derived from the leave extracts of Mitragyna speciosa Korth or Mitragyna speciosa (M. speciosa), a medicinal plant from South East Asia used legally in many countries as stimulant
Jun Lu, Heming Wei, Jianjun Wu, Mohd Fadzly Amar Jamil, Mei Lan Tan, Mohd Ilham Adenan, Philip Wong, Winston Shim   +7 more
doaj   +1 more source

Mitragynine (Kratom)-Induced Cognitive Impairments in Mice Resemble Δ9-THC and Morphine Effects: Reversal by Cannabinoid CB1 Receptor Antagonism

Frontiers in Pharmacology, 2021
Kratom is a widely abused plant-based drug preparation with a global interest in recent years, well beyond its native grounds in Southeast Asia. Mitragynine, its major psychoactive constituent is known to exhibit opioid-like behavioral effects with ...
Ismail Nurul Iman, Nur Aimi Zawami Ahmad, Nurul Aiman Mohd Yusof, Ummi Nasrah Talib, Anwar Norazit, Jaya Kumar, Muhammad Zulfadli Mehat, Zurina Hassan, Christian P. Müller, Christian P. Müller, Mustapha Muzaimi   +10 more
doaj   +1 more source