Results 11 to 20 of about 2,217 (207)

In Vitro Pharmacology of Mitragynine at α-Adrenoceptors. [PDF]

ACS Chem Neurosci
Mitragynine is a psychoactive alkaloid in Mitragyna speciosa with unique polypharmacology at G protein-coupled receptors. In addition to its well-known partial agonist activity at opioid receptors, mitragynine is an antagonist at human α2A-adrenoceptors (α2ARs), as measured in an in vitro GTPγS G protein assay.
Chen Y, Seto J, Obeng S, Mottinelli M, Mukhopadhyay S, Tyagi R, Hampson AJ, McCurdy CR, McMahon LR, Moniri NH, Canal CE.   +10 more
europepmc   +4 more sources

Environmental Influence on the Untargeted Foliar Metabolome of Naturally Growing Mitragyna Species in Thailand. [PDF]

Plant Environ Interact
ABSTRACT This study investigates the foliar secondary metabolite profiles of four Mitragyna species naturally occurring in Thailand: M. diversifolia, M. hirsuta, M. rotundifolia, and M. speciosa (kratom). Using untargeted gas chromatography–mass spectrometry (GC–MS), 409 secondary volatile metabolites were annotated across the four species.
Andriyas T, Leksungnoen N, Ngernsaengsaruay C, Uthairatsamee S, Tansawat R, Sirilertpanich P.   +5 more
europepmc   +2 more sources

Human Mitragynine and 7-Hydroxymitragynine Pharmacokinetics after Single and Multiple Daily Doses of Oral Encapsulated Dried Kratom Leaf Powder

Molecules
Kratom leaves, consumed by millions worldwide as tea or ground leaf powder, contain multiple alkaloids, with mitragynine being the most abundant and responsible for most effects.
Marilyn A Huestis, Martin Brett
exaly   +3 more sources

Screening, docking, and molecular dynamics analysis of Mitragyna speciosa (Korth.) compounds for targeting HER2 in breast cancer [PDF]

Current Research in Structural Biology
Breast cancer remains the most commonly diagnosed cancer among women worldwide, with approximately 2.3 million new cases reported in 2022. In the United States alone, an estimated 310,720 new cases of female breast cancer are expected in 2024.
Nabila Hadiah Akbar, Farendina Suarantika, Taufik Muhammad Fakih, Ariranur Haniffadli, Khoirunnisa Muslimawati, Aditya Maulana Perdana Putra   +5 more
doaj   +2 more sources

Inhibitory effects of Kratom constituents, mitragynine and 7-hydroxymitragynine, on 4-methylumbelliferone glucuronidation by human UDP-glucuronosyltransferases [PDF]

Toxicology Reports
As Kratom use increases, concerns about potential herb-drug interactions with liver enzymes, particularly UDP-glucuronosyltransferases (UGTs), have emerged.
Verawan Uchaipichat
doaj   +2 more sources

Alkaloid biosynthesis in medicinal crop kratom (Mitragyna speciosa) varies with postharvest, genetic, and seasonal factors [PDF]

Frontiers in Plant Science
IntroductionKratom (Mitragyna speciosa), a medicinally valuable ethnobotanical tree native to Southeast Asia, has traditionally been used to combat fatigue and enhance productivity.
Mengzi Zhang, Annabella Lyndon, Siva Rama Raju Kanumuri, Abhisheak Sharma, Abhisheak Sharma, Brian J. Pearson, Brian J. Pearson, Christopher R. McCurdy, Christopher R. McCurdy, Jianjun Chen   +9 more
doaj   +2 more sources

Reported associations between kratom and seizures: a systematic review [PDF]

Frontiers in Pharmacology
Statement of purpose, innovation or hypothesisKratom, derived from the leaves of the plant Mitragyna speciosa, is an herbal supplement that has been used medically and recreationally for centuries, but has recently gained popularity in the United States ...
Toby Turla, Grayson Abele, My Hua, Dennis Paustenbach   +3 more
doaj   +2 more sources

New psychoactive substances in roadway crash victims in California [PDF]

Frontiers in Toxicology
BackgroundMotor vehicle crashes (MVCs) are a major global health concern. While alcohol continues to be a significant contributor to MVCs, the role of illicit and prescription drugs has increased in the last 4 decades.
Roy Gerona, Daniel Tomer, Donovan Nielsen, Allyson C. Sage, Deborah French, Juliana Tolles, James Alan Chenoweth   +6 more
doaj   +2 more sources

Higher accumulation of mitragynine in Mitragyna speciosa (kratom) leaves affected by insect attack. [PDF]

PLoS ONE
Kratom leaves are widely consumed by locals to increase their stamina for working longer hours in the field. However, insect damage to the leaves can lead to significant loss of leaf harvest. Despite this, there remains considerable uncertainty regarding
Nisa Leksungnoen, Tushar Andriyas, Rossarin Tansawat, Pichaya Pongchaidacha, Piyawadi Khaoiam, Thanundorn Thanusuwannasak, Chatchai Ngernsaengsaruay, Chawatat Thanoosing, Suwimon Uthairatsamee   +8 more
doaj   +2 more sources

Exploring the Therapeutic Potential of Mitragynine and Corynoxeine: Kratom-Derived Indole and Oxindole Alkaloids for Pain Management [PDF]

Pharmaceuticals
The search for effective pain management solutions remains a critical challenge, especially amidst growing concerns over the use of conventional opioids.
Ahmed S. Alford, Hope L. Moreno, Menny M. Benjamin, Cody F. Dickinson, Mark T. Hamann   +4 more
doaj   +2 more sources