Results 41 to 50 of about 1,701 (157)

Mitragynine attenuates withdrawal syndrome in morphine-withdrawn zebrafish.

PLoS ONE, 2011
A major obstacle in treating drug addiction is the severity of opiate withdrawal syndrome, which can lead to unwanted relapse. Mitragynine is the major alkaloid compound found in leaves of Mitragyna speciosa, a plant widely used by opiate addicts to ...
Beng-Siang Khor, Mohd Fadzly Amar Jamil, Mohamad Ilham Adenan, Alexander Chong Shu-Chien   +3 more
doaj   +1 more source

Mitragynine Attenuates Morphine Withdrawal Effects in Rats—A Comparison With Methadone and Buprenorphine

Frontiers in Psychiatry, 2020
BackgroundOpiate addiction is a major health problem in many countries. A crucial component of the medical treatment is the management of highly aversive opiate withdrawal signs, which may otherwise lead to resumption of drug taking.
Rahimah Hassan, Cheah Pike See, Sasidharan Sreenivasan, Sharif M. Mansor, Christian P. Müller, Zurina Hassan, Zurina Hassan   +6 more
doaj   +1 more source

Seasonal and Geographic Variation in Alkaloid Content of Kratom (Mitragyna speciosa (Korth.) Havil.) from Thailand

Plants, 2023
The objective of this study was to obtain data on the distribution of alkaloids in kratom plants grown in Thailand. Two collections were performed, covering the southern, central, and northern regions of Thailand and different seasons.
Narumon Sengnon, Phanita Vonghirundecha, Wiraphon Chaichan, Thaweesak Juengwatanatrakul, Jumpen Onthong, Pongmanat Kitprasong, Somchai Sriwiriyajan, Somsmorn Chittrakarn, Supattra Limsuwanchote, Juraithip Wungsintaweekul   +9 more
doaj   +1 more source

Inhibitory effects of Kratom constituents, mitragynine and 7-hydroxymitragynine, on 4-methylumbelliferone glucuronidation by human UDP-glucuronosyltransferases

Toxicology Reports
As Kratom use increases, concerns about potential herb-drug interactions with liver enzymes, particularly UDP-glucuronosyltransferases (UGTs), have emerged.
Verawan Uchaipichat
doaj   +1 more source

Induction and Analysis of the Alkaloid Mitragynine Content of a Mitragyna speciosa Suspension Culture System upon Elicitation and Precursor Feeding

The Scientific World Journal, 2013
This study aimed to determine the effects of different concentrations and combinations of the phytohormones 2,4-dichlorophenoxy acetic acid (2,4-D), kinetin, 6-benzylaminopurine (BAP), and 1-naphthaleneacetic acid (NAA) on callus induction ...
Nor Nahazima Mohamad Zuldin, Ikram Md. Said, Normah Mohd Noor, Zamri Zainal, Chew Jin Kiat, Ismanizan Ismail   +5 more
doaj   +1 more source

Determination of Psychoactive Mitragynine Drug in Suspected Kratom Species Collected from Various Geographical Areas in the Philippines: A Pilot Study on Existing Local Plant-based New Psychoactive Su

Arab Journal of Forensic Sciences & Forensic Medicine, 2019
Kratom is a tropical tree indigenous to South East Asian countries and has been traditionally used by natives to increase work efficiency and treat selected illnesses.
Atty. Severino P. Uy, Shaila Jr, S. Seville, Jasmyne L. M. Jaranilla, Yvette K. S. Desamito, Reynalyn P. Barbacena, Ronald J. A. Narceda   +5 more
doaj   +1 more source

Variations in mitragynine content in the naturally growing Kratom (Mitragyna speciosa) population of Thailand

Frontiers in Plant Science, 2022
We analyzed the content of mitragynine (MG) found in kratom leaves (Mitragyna speciosa) and the influence of different environmental conditions (air and soil variables) on the yield in various regions of Thailand.
Nisa Leksungnoen, Nisa Leksungnoen, Nisa Leksungnoen, Tushar Andriyas, Chatchai Ngernsaengsaruay, Suwimon Uthairatsamee, Phruet Racharak, Weerasin Sonjaroon, Roger Kjelgren, Brian J. Pearson, Christopher R. McCurdy, Abhisheak Sharma   +11 more
doaj   +1 more source

An exploratory study of the safety profile and neurocognitive function after single doses of mitragynine in humans [PDF]

Rationale: Despite the growing scientific interest on mitragynine, the primary alkaloid in kratom (Mitragyna Speciosa), there is a lack of clinical trials in humans.
Cavarra, Mauro, Corazza, Ornella, Pasquini, Massimo, Ramaekers, Johannes G., Prevete, Elisabeth, Theunissen, Eef L., Kuypers, Kim P. C., Reckweg, Johannes T., Toennes, Stefan W., Ritscher, Sabrina, Bersani, Giuseppe, Theunissen, Eef L.; id_orcid, Paci, Riccardo   +12 more
core   +1 more source

Mitragyna speciosa: Opioid Addiction Treatment and Risk of Use

JPSCR: Journal of Pharmaceutical Science and Clinical Research, 2022
Kratom (Mitragyna speciosa (Korth.) Havil.) is a plant that originated from the rainforest in Southeast Asia, mainly grows in Thailand, Malaysia, and Indonesia. Kratom has been used traditionally as an herbal remedy for the treatment of various illnesses.
Azka Muhammad Rusydan, Endang Lukitaningsih, Nanang Fakhrudin   +2 more
doaj   +1 more source

Metal‐Catalyzed C(sp2)–H Bond Functionalization of Indolinone‐ and Indanone‐Type Chemical Platforms En Route Toward Late‐Stage Functionalization

Advanced Synthesis &Catalysis, Volume 368, Issue 8, 15 April 2026.
An in‐depth survey dealing with the aromatic C—H bond functionalization of biologically‐relevant scaffolds featuring the indolinone and indanone core is discussed as they are unique aromatic scaffolds that are 1,2‐doubly fused with small five‐membered rings.
Vanessa Delahaye, Sylvie Dérien, Mathieu Achard, Rafael Gramage‐Doria   +3 more
wiley   +1 more source