Results 1 to 10 of about 761 (124)

Human Mitragynine and 7-Hydroxymitragynine Pharmacokinetics after Single and Multiple Daily Doses of Oral Encapsulated Dried Kratom Leaf Powder [PDF]

Molecules
Kratom leaves, consumed by millions worldwide as tea or ground leaf powder, contain multiple alkaloids, with mitragynine being the most abundant and responsible for most effects.
Marilyn A Huestis, Martin Brett
exaly   +7 more sources

7‑Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects [PDF]

ACS Central Science, 2019
Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction.
Andrew C. Kruegel, Rajendra Uprety, Steven G. Grinnell, Cory Langreck, Elizabeth A. Pekarskaya, Valerie Le Rouzic, Michael Ansonoff, Madalee M. Gassaway, John E. Pintar, Gavril W. Pasternak, Jonathan A. Javitch, Susruta Majumdar, Dalibor Sames   +12 more
doaj   +5 more sources

Inhibitory effects of Kratom constituents, mitragynine and 7-hydroxymitragynine, on 4-methylumbelliferone glucuronidation by human UDP-glucuronosyltransferases [PDF]

Toxicology Reports
As Kratom use increases, concerns about potential herb-drug interactions with liver enzymes, particularly UDP-glucuronosyltransferases (UGTs), have emerged.
Verawan Uchaipichat
exaly   +4 more sources

From kratom to 7-hydroxymitragynine: evolution of a natural remedy into a public-health threat [PDF]

Pharmaceutical Biology
Context Kratom (Mitragyna speciosa), native to Southeast Asia, has traditionally been consumed as fresh leaves or teas. Under those conditions, exposure to 7-hydroxymitragynine (7-OH)—a potent μ-opioid receptor agonist—is minimal, as it occurs only at ...
George Pro, Igor Koturbash, Scott Alsbrook   +2 more
exaly   +4 more sources

Discovery of rhynchophylline and mitraphylline in two Thai Mitragyna species and the investigation of their biological activity via opioid gene expression analysis [PDF]

Scientific Reports
Mitragyna speciosa (Ms), M. diversifolia (Md), M. hirsuta (Mh) and M. rotundifolia (Mr) were investigated for phytochemicals by GC-MS and GC-FID, cytotoxicity and genotoxicity testing by MTT and comet assay, and biological activity examination through ...
Runglawan Sudmoon, Tawatchai Tanee, Warin Wonok, Unchaleeporn Ameamsri, Thomas Liehr, Sakda Daduang, Pornnarong Siripiyasing, Arunrat Chaveerach   +7 more
doaj   +4 more sources

Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder [PDF]

Frontiers in Pharmacology, 2021
Background and Purpose:Mitragyna speciosa extract and kratom alkaloids decrease alcohol consumption in mice at least in part through actions at the δ-opioid receptor (δOR).
Anna M. Gutridge, Soumen Chakraborty, Balazs R. Varga, Elizabeth S. Rhoda, Alexander R. French, Alexander R. French, Arryn T. Blaine, Quinten H. Royer, Haoyue Cui, Jinling Yuan, Robert J. Cassell, Robert J. Cassell, Márk Szabó, Susruta Majumdar, Richard M. van Rijn, Richard M. van Rijn, Richard M. van Rijn   +16 more
doaj   +3 more sources

Bayesian inference for integrated pharmacokinetic modelling of mitragynine and 7-hydroxymitragynine [PDF]

ADMET and DMPK
Background and purpose: Mitragynine is an active compound in kratom that is metabolized to the pharmacologically active 7-hydroxymitragynine, requiring an integrated pharmacokinetic approach to maintain plasma concentrations of both within the optimal ...
Dion Notario, Untung Gunawan, Pretty Falena Atmanda Kambira, Erna Wulandari, Eko Adi Prasetyanto   +4 more
doaj   +2 more sources

In silico investigation of mitragynine and 7-hydroxymitragynine metabolism [PDF]

BMC Research Notes, 2019
Objective Mitragynine is the main active compound of Mitragyna speciose (Kratom in Thai). The understanding of mitragynine derivative metabolism in human body is required to develop effective detection techniques in case of drug abuse or establish an ...
Taweetham Limpanuparb, Rattha Noorat, Yuthana Tantirungrotechai   +2 more
doaj   +2 more sources

Mitragyna speciosa: Opioid Addiction Treatment and Risk of Use [PDF]

JPSCR: Journal of Pharmaceutical Science and Clinical Research, 2022
Kratom (Mitragyna speciosa (Korth.) Havil.) is a plant that originated from the rainforest in Southeast Asia, mainly grows in Thailand, Malaysia, and Indonesia. Kratom has been used traditionally as an herbal remedy for the treatment of various illnesses.
Azka Muhammad Rusydan, Endang Lukitaningsih, Nanang Fakhrudin   +2 more
doaj   +3 more sources

Screening, docking, and molecular dynamics analysis of Mitragyna speciosa (Korth.) compounds for targeting HER2 in breast cancer [PDF]

Current Research in Structural Biology
Breast cancer remains the most commonly diagnosed cancer among women worldwide, with approximately 2.3 million new cases reported in 2022. In the United States alone, an estimated 310,720 new cases of female breast cancer are expected in 2024.
Nabila Hadiah Akbar, Farendina Suarantika, Taufik Muhammad Fakih, Ariranur Haniffadli, Khoirunnisa Muslimawati, Aditya Maulana Perdana Putra   +5 more
doaj   +2 more sources