Results 41 to 50 of about 76,183,421 (152)

Mitragyna speciosa: Opioid Addiction Treatment and Risk of Use

JPSCR: Journal of Pharmaceutical Science and Clinical Research, 2022
Kratom (Mitragyna speciosa (Korth.) Havil.) is a plant that originated from the rainforest in Southeast Asia, mainly grows in Thailand, Malaysia, and Indonesia. Kratom has been used traditionally as an herbal remedy for the treatment of various illnesses.
Azka Muhammad Rusydan, Endang Lukitaningsih, Nanang Fakhrudin   +2 more
doaj   +1 more source

A Review of Kratom Product Evolution and Its Associated Health Outcomes. [PDF]

Subst Abuse Rehabil
Shereen Aly, Oliver GrundmannDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USACorrespondence: Oliver Grundmann, Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1345 Center ...
Aly S, Grundmann O.
europepmc   +2 more sources

Screening, docking, and molecular dynamics analysis of Mitragyna speciosa (Korth.) compounds for targeting HER2 in breast cancer. [PDF]

Curr Res Struct Biol
Breast cancer remains the most commonly diagnosed cancer among women worldwide, with approximately 2.3 million new cases reported in 2022. In the United States alone, an estimated 310,720 new cases of female breast cancer are expected in 2024.
Akbar NH, Suarantika F, Fakih TM, Haniffadli A, Muslimawati K, Putra AMP.   +5 more
europepmc   +2 more sources

DNA Barcoding and Chemical Profile Using UHPLC, GC-MS and LC-MS/QTOF of <i>Mitragyna speciosa</i> Variation and Allied Species for Quality Control of Kratom Materials. [PDF]

Plants (Basel)
Kratom (Mitragyna speciosa Korth.) has gained increasing global attention due to its traditional use, psychoactive properties, and emerging therapeutic potential; however, concerns regarding adulteration, substitution, and inconsistent quality of ...
Anantaworasakul P, Arunotayanun W, Chaichit S, Khamnuan S, Ngernsaengsaruay C, Chittasupho C, Leksungnoen N, Na Takuathung M, Yubolphan R, Jiso A, Techarang T, Intharuksa A.   +11 more
europepmc   +2 more sources

Simultaneous quantification of seventeen kratom alkaloids and metabolites in human plasma and its application to clinical pharmacokinetic sample analysis. [PDF]

Pharm Biol
Context Mitragyna speciosa Korth, commonly known as kratom, has been used traditionally in Southeast Asia by chewing fresh leaves and brewing decoctions (tea) for its stimulant and sedative-like properties. Despite its widespread use, controlled clinical
Kanumuri SRR, Gundeti M, Mukhopadhyay S, Zeilinger NZ, Zamarripa CA, Smith KE, McCurdy CR, Sharma A.   +7 more
europepmc   +2 more sources

G protein‐biased kratom‐alkaloids and synthetic carfentanil‐amide opioids as potential treatments for alcohol use disorder

British Journal of Pharmacology, Volume 177, Issue 7, Page 1497-1513, April 2020., 2020
▪ Background and Purpose Mitragyna speciosa, more commonly known as kratom, is a plant that contains opioidergic alkaloids but is unregulated in most countries. Kratom is used in the self‐medication of chronic pain and to reduce illicit and prescription opioid dependence.
Anna M. Gutridge, Meridith T. Robins, Robert J. Cassell, Rajendra Uprety, Kendall L. Mores, Mee Jung Ko, Gavril W. Pasternak, Susruta Majumdar, Richard M. van Rijn   +8 more
wiley   +1 more source

A Case of Kratom Overdose in a Pediatric Patient

Case Reports in Psychiatry, Volume 2020, Issue 1, 2020., 2020
Kratom is a synthetic opioid that is federally unregulated and thus available for purchase through online retail and smoke shops in most states. Due to its availability, there is concern for misuse in the pediatric population. There is existing literature describing toxicity of kratom in adults; yet, to the best of our knowledge, there are no cases ...
Andrew Wong, Monique Mun, Daisuke Matsuzawa   +2 more
wiley   +1 more source

Assessment of Contribution of 7‐Hydroxymitragynine and Mitragynine Pseudoindoxyl to the MU‐Opioid Activity of Mitragynine

The FASEB Journal, 2021
Our group has demonstrated that the primary kratom alkaloid mitragynine (MG) is metabolized in vivo into 7‐hydroxymitragynine (7‐OH‐MG), which is in turn converted into MG pseudoindoxyl (MG‐P). Here we compared their µ‐opioid receptor (MOR) pharmacology and contribution of the two metabolites
Morgan Crowley, Samuel Obeng, Avi Patel, Lea Gamez‐Jimenez, Luis Restrepo, Nicholas Ho, Manuel Alvarez, Amsha Thadisetti, Elizabeth Kern, Victoria Pallares, Francisco Leon, Marco Mottinelli, Julio Zuarth Gonzalez, Christopher McCurdy, Lance McMahon, Takato Hiranita   +15 more
openaire   +1 more source

Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution: : the missing link in pharmacodynamic studies

, 2018
Mitragyna speciosa is reported to be beneficial for the management of chronic pain and opioid withdrawal in the evolving opioid epidemic. Data on the blood-brain barrier (BBB) transport of mitragynine and 7-hydroxymitragynine, the active compounds of the
Margareta, Hammarlund-Udenaes, Teh, Eng-Huat, Hanapi, Nur Aziah, Loryan, Irena, Mohideen, Mazlin, Mohamad Arshad, Ahmad Saifuddin, Mohd Uzid, Mahathir, Mordi, Mohd Nizam, Yusof, Siti R, Siti R. Yusof, Hammarlund-Udenaes, Margareta,, Mohd Nizam Mordi, Mordi, Mohd Nizam,, Irena Loryan, Mohideen, Mazlin,, Teh, Eng-Huat,, Hanapi, Nur Aziah,, Eng‐Huat Teh, Yusof, Siti R,, Nur Aziah Hanapi, Mohd Uzid, Mahathir,, Loryan, Irena,, Mazlin Mohideen, Mohamad Arshad, Ahmad Saifuddin,, Margareta Hammarlund‐Udenaes, Mahathir Mohd Uzid, Ahmad Saifuddin Mohamad Arshad   +26 more
core   +2 more sources

Alkaloid biosynthesis in medicinal crop kratom (<i>Mitragyna speciosa</i>) varies with postharvest, genetic, and seasonal factors. [PDF]

Front Plant Sci
IntroductionKratom (Mitragyna speciosa), a medicinally valuable ethnobotanical tree native to Southeast Asia, has traditionally been used to combat fatigue and enhance productivity.
Zhang M, Lyndon A, Kanumuri SRR, Sharma A, Pearson BJ, McCurdy CR, Chen J.   +6 more
europepmc   +2 more sources