Results 41 to 50 of about 824 (158)
Molecules, 2023 Kratom (Mitragyna speciosa Korth. Havil) has been considered a narcotic drug for years, barred by the law in many parts of the world, while extensive research over the past few decades proves its several beneficial effects, some of which are still in ...
Rahni Hossain +6 more
doaj +1 more source
PLoS ONE, 2022 Leaves harvested from kratom [Mitragyna speciosa (Korth.)] have a history of use as a traditional ethnobotanical medicine to combat fatigue and improve work productivity in Southeast Asia. In recent years, increased interest in the application and use of
Mengzi Zhang +6 more
doaj +2 more sources
Development and validation of a UPLC‐MS/MS method for the determination of 7‐hydroxymitragynine, a μ‐opioid agonist, in rat plasma and its application to a pharmacokinetic study [PDF]
Biomedical Chromatography, 2013 Christopher R Mccurdy, Bonnie A Avery
exaly +2 more sources
Herbal highs: review on psychoactive effects and neuropharmacology [PDF]
, 2017 Background: A new trend among users of new psychoactive substances’ the consumption of “herbal highs”: plant parts containing psychoactive substances.
Graziano, S +5 more
core +1 more source
British Journal of Pharmacology, Volume 177, Issue 7, Page 1497-1513, April 2020., 2020 ▪ Background and Purpose Mitragyna speciosa, more commonly known as kratom, is a plant that contains opioidergic alkaloids but is unregulated in most countries. Kratom is used in the self‐medication of chronic pain and to reduce illicit and prescription opioid dependence.
Anna M. Gutridge +8 more
wiley +1 more source
Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit beta-Arrestin-2. [PDF]
, 2016 Natural products found in Mitragyna speciosa, commonly known as kratom, represent diverse scaffolds (indole, indolenine, and spiro pseudoindoxyl) with opioid activity, providing opportunities to better understand opioid pharmacology.
Borics, Attila +5 more
core +1 more source
The FASEB Journal, 2021 Our group has demonstrated that the primary kratom alkaloid mitragynine (MG) is metabolized in vivo into 7‐hydroxymitragynine (7‐OH‐MG), which is in turn converted into MG pseudoindoxyl (MG‐P). Here we compared their µ‐opioid receptor (MOR) pharmacology and contribution of the two metabolites
Morgan Crowley +15 more
openaire +1 more source
A Case of Kratom Overdose in a Pediatric Patient
Case Reports in Psychiatry, Volume 2020, Issue 1, 2020., 2020 Kratom is a synthetic opioid that is federally unregulated and thus available for purchase through online retail and smoke shops in most states. Due to its availability, there is concern for misuse in the pediatric population. There is existing literature describing toxicity of kratom in adults; yet, to the best of our knowledge, there are no cases ...
Andrew Wong +2 more
wiley +1 more source
Evaluating kratom alkaloids using PHASE.
PLoS ONE, 2020 Kratom is a botanical substance that is marketed and promoted in the US for pharmaceutical opioid indications despite having no US Food and Drug Administration approved uses.
Christopher R Ellis +9 more
doaj +1 more source
Indolo[2,3-a]quinolizidines and derivatives: Bioactivity and asymmetric Synthesis [PDF]
, 2016 Corynantheine alkaloids with a tetracyclic indole[2,3-a]-quinolizidine motif are an important issue in academia and in the life science industries due to their broad bioactivity profile.
Espadinha, Margarida +2 more
core +1 more source