Results 31 to 40 of about 824 (158)

Cytotoxicity of extract of Malaysian Mitragyna Speciosa Korth and its dominant Alkaloid Mitragynine [PDF]

, 2008
Mitragyna speciosa Korth (Kratom), a herb of the Rubiaceae family is indigenous in southeast Asia mainly in Malaysia and Thailand. It is used as an opium substitute and has been increasingly abused by drug addicts in Malaysia.
Saidin, Nor Aini, Saidin, Nor Aini
core   +5 more sources

Case Report: Treatment of Kratom Use Disorder With a Classical Tricyclic Antidepressant

Frontiers in Psychiatry, 2021
Kratom or Mitragyna speciosa (Korth.) is an evergreen tree of the coffee family native to South-East Asia and Australasia. It is used by locals recreationally to induce stimulant and sedative effects and medically to soothe pain and opiate withdrawal ...
Alessandro E. Vento, Alessandro E. Vento, Simone de Persis, Sergio De Filippis, Fabrizio Schifano, Flavia Napoletano, John M. Corkery, Georgios D. Kotzalidis, Georgios D. Kotzalidis   +8 more
doaj   +1 more source

Biosynthesis of kratom opioids

New Phytologist, Volume 240, Issue 2, Page 757-769, October 2023., 2023
Summary Mitragynine, an analgesic alkaloid from the plant Mitragyna speciosa (kratom), offers a safer alternative to clinical opioids such as morphine, owing to its more favorable side effect profile. Although kratom has been traditionally used for stimulation and pain management in Southeast Asia, the mitragynine biosynthesis pathway has remained ...
Kyunghee Kim, Mohammadamin Shahsavarani, Jorge Jonathan Oswaldo Garza‐García, Jack Edward Carlisle, Jun Guo, Vincenzo De Luca, Yang Qu   +6 more
wiley   +1 more source

Clinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom

Clinical Pharmacology &Therapeutics, Volume 113, Issue 6, Page 1315-1325, June 2023., 2023
Oral formulations prepared from the leaves of the kratom (Mitragyna speciosa) plant are increasingly used for their opioid‐like effects to self‐manage opioid withdrawal and pain. Calls to US poison centers involving kratom exposures increased >50‐fold from 2011–2017, one‐third of which reported concomitant use of kratom with drugs of abuse.
Rakshit S. Tanna, James T. Nguyen, Deena L. Hadi, Matthew E. Layton, John R. White, Nadja B. Cech, Nicholas H. Oberlies, Allan E. Rettie, Kenneth E. Thummel, Mary F. Paine   +9 more
wiley   +1 more source

Mitragyna Species as Pharmacological Agents: From Abuse to Promising Pharmaceutical Products

Life, 2022
Mitragyna is a genus belonging to the Rubiaceae family and is a plant endemic to Asia and Africa. Traditionally, the plants of this genus were used by local people to treat some diseases from generation to generation.
Islamudin Ahmad, Wisnu Cahyo Prabowo, Muhammad Arifuddin, Jaka Fadraersada, Niken Indriyanti, Herman Herman, Reza Yuridian Purwoko, Firzan Nainu, Anton Rahmadi, Swandari Paramita, Hadi Kuncoro, Nur Mita, Angga Cipta Narsa, Fajar Prasetya, Arsyik Ibrahim, Laode Rijai, Gemini Alam, Abdul Mun’im, Sukanya Dej-adisai   +18 more
doaj   +1 more source

Genotoxicity risk assessment of a 7-hydroxymitragynine-enriched Kratom preparation: An integrated in silico and in vitro approach. [PDF]

Toxicol Rep
The increasing global use of Mitragyna speciosa (Kratom) necessitates a thorough safety assessment, particularly regarding the genotoxic potential of its key alkaloids. This study employed an integrated in silico and in vitro approach to evaluate the genotoxicity of a well-characterized, semi-synthetically enhanced Kratom preparation (SKP) enriched in ...
Harnkit N, Sahad T, Noonate I, Primpai P, Radapong S, Pipatrattanaseree W, Sincharoenpokai P, Chamnanpuen P.   +7 more
europepmc   +3 more sources

An evaluation of adverse drug reactions and outcomes attributed to kratom in the US Food and Drug Administration Adverse Event Reporting System from January 2004 through September 2021

Clinical and Translational Science, Volume 16, Issue 6, Page 1002-1011, June 2023., 2023
Abstract Kratom is a widely used Asian botanical that has gained popularity in the United States due to a perception that it can treat pain, anxiety, and opioid withdrawal symptoms. The American Kratom Association estimates 10–16 million people use kratom.
Xiaotong Li, Patrick Ndungu, Sanya B. Taneja, Maryann R. Chapin, Susan B. Egbert, Krishi Akenapalli, Mary F. Paine, Sandra L. Kane‐Gill, Richard D. Boyce   +8 more
wiley   +1 more source

Drug testing for mitragynine and kratom: Analytical challenges and medico‐legal considerations

Drug Testing and Analysis, Volume 15, Issue 2, Page 213-219, February 2023., 2023
The use of kratom, that is, leaves from the Southeast Asian tree Mitragyna speciosa, has spread to the Western world. Kratom contain several alkaloids including mitragynine and its three diastereomers mitraciliatine, speciogynine and speciociliatine. In Sweden, only mitragynine is classified.
Anders Helander, Alexia Rylski
wiley   +1 more source

Kratom Consumption can be Addictive and have Adverse Health Effects [PDF]

Novelty in Clinical Medicine, 2022
Kratom, also known as herbal speed, is the powdered leaves of the Asian kratom tree (Mitragyna speciosa Korth.). The consumption of kratom powder or kratom tea for diarrhea, inflammation, fever, and pain, but also for anxiety and depression is based on ...
Martin Hofmeister
doaj   +1 more source

Kratom: The analytical challenge of an emerging herbal drug [PDF]

, 2023
Mitragyna speciosa or kratom is emerging worldwide as a “legal” herbal drug of abuse. An increasing number of papers is appearing in the scientific literature regarding its pharmacological profile and the analysis of its chemical constituents, mainly ...
Cannazza, Giuseppe, Capriotti, Anna Laura, Citti, Cinzia, Laganà, Aldo, Montone, Carmela Maria   +4 more
core   +4 more sources