Results 61 to 70 of about 76,183,421 (152)

Is kratom contributing to deaths in polypharmacy cases? A scoping review

Frontiers in Toxicology
Kratom (Mitragyna speciosa) is used by an estimated 10–16 million Americans for self-management of pain, anxiety, and opioid use disorder, yet its causal contribution to associated deaths remains unresolved.
Ella Matischak, Ella Matischak, Lyle D. Burgoon, Lyle D. Burgoon   +3 more
doaj   +1 more source

The Analysis of Commercially Available Kratom Products in Richmond, Virginia [PDF]

, 2022
Kratom is a novel psychoactive substance that has gained popularity within the past ten years. Originating from Southeast Asia, the leaves of the Mitragyna speciosa tree contain two principal alkaloids, mitragynine and 7-hydroxymitragynine, that play a ...
Fleming, James H, Jr, Peace, Michelle R, Alves, Emanuele A, Poklis, Justin   +3 more
core   +3 more sources

Assessment of Abuse Potential‐Related Effects of Oral Dried Kratom Leaf Powder in Healthy Normal Participants Following Single and Multiple Daily Doses

Drug Testing and Analysis, Volume 18, Issue 7, Page 922-932, July 2026.
In a randomized, double‐blind, placebo‐controlled study of oral dried kratom leaf powder in healthy kratom‐naive adults, no participants met the clinically meaningful opioid withdrawal threshold; abuse‐related treatment‐emergent adverse events occurred more frequently at higher doses but were generally mild and resolved without sequelae; and no serious
Marion Coe, Marilyn Huestis, Daniel Wang, Thomas Hudzik, John Bothmer, Jack Henningfield   +5 more
wiley   +1 more source

Kratom Kinetics: Mitragynine to 7-Hydroxymitragynine Conversion in Human Liver Microsomes

, 2022
https://rdc.reed.edu/v1/resources/f44e09da-e729-4b2d-b203-e178a41e99fa/thumb/128.jpgMitragyna Speciosa, also known as kratom, is a tropical Southeast Asian tree whose leaves have traditionally been used as a pain reliever, stimulant, or treatment for ...
Jed, Ana
core  

Metabolomics data of Mitragyna speciosa leaf using LC-ESI-TOF-MS

Data in Brief, 2018
Mitragyna speciosa is a psychoactive plant known as “ketum” in Malaysia and “kratom” in Thailand. This plant is distinctly known to produce two important alkaloids, namely mitragynine (MG) and 7-hydroxymitragynine (7-OH-MG) that can bind to opioid ...
Rubashiny Veeramohan, Kamalrul Azlan Azizan, Wan Mohd Aizat, Hoe-Han Goh, Sharif Mahsufi Mansor, Nur Sabrina Mohd Yusof, Syarul Nataqain Baharum, Chyan Leong Ng   +7 more
doaj   +1 more source

Kratom use disorder as a gateway to an opioid use disorder

European Psychiatry, 2023
Introduction Kratom (Mitragyna speciosa) is a psychoactive substance native to Thailand and Southeast Asia with stimulant-like effects at lower doses and opioid-like effects at higher doses.
A. C. Borges, D. Machado
doaj   +1 more source

Broad evidence of xylazine in the UK illicit drug market beyond heroin supplies: Triangulating from toxicology, drug‐testing and law enforcement

Addiction, Volume 119, Issue 7, Page 1301-1309, July 2024.
Abstract Background and aims Xylazine is a non‐opioid sedative which has spread rapidly throughout the US illicit drug supply. This study aimed to describe the spread of xylazine throughout the UK illicit drug supply. Methods Xylazine detections in human biological samples were collated from toxicology laboratories operating in the United Kingdom with ...
Caroline S. Copeland, Kathleen Rice, Kirsten L. Rock, Simon Hudson, Peter Streete, Alexander J. Lawson, Lewis Couchman, Adam Holland, Stephen Morley   +8 more
wiley   +1 more source

MOESM2 of In silico investigation of mitragynine and 7-hydroxymitragynine metabolism

, 2019
Additional file 2. Table S1, Figures S1 and S2 for the molecular structures and energies of reaction.
Limpanuparb, Taweetham, Noorat, Rattha, Tantirungrotechai, Yuthana   +2 more
openaire   +1 more source

Kratom (Mitragyna speciosa) for pain management: a systematic review of preclinical evidence and limited clinical data

Phytomedicine Plus
Introduction: Kratom (Mitragyna speciosa) has gained attention as a potential analgesic due to its major alkaloid, mitragynine, which exhibits atypical opioid activity with reduced β-arrestin recruitment.
Christrijogo Soemartono Waloejo, Prananda Surya Airlangga, Bambang Pujo Semedi, Anna Surgean Veterini, Kohar Hari Santoso, Moses Glorino Rumambo Pandin, Dedi Susila, Soni Sunarso Sulistiawan, Cornellius Hendra Purnama Aria Sumantrie, Adi Nugraha Dj Anwar, Gusti Pindo Asa Anindito, Rahmat Kukuh Noviandomo, Dian Anggraini Permatasari Musalim, David Setyo Budi   +13 more
doaj   +1 more source

Quantitative Analysis of Mitragynine in Consumer Products Labeled as Kratom [PDF]

, 2019
Mitrgyna speciosa is a tropical evergreen tree native to Southeast Asia. The leaves of this tree are referred to as kratom and contain over 35 alkaloids of which some have been reported to have stimulant and analgesic properties.
Kyle Steven Rybarczyk (7974767)
core   +3 more sources