Results 81 to 90 of about 76,183,421 (152)

Optimizing ultrasound-assisted extraction for enhanced quantification of 7-hydroxymitragynine and mitragynine in kratom

Creative Science
This study focuses on optimizing the extraction of two key alkaloids, mitragynine and 7-hydroxy mitragynine, from kratom (Mitragyna speciosa) leaves using ultrasound-assisted extraction (UAE). The aim was to identify optimal extraction conditions by varying sample-to-liquid ratio, solvent types, methanol concentrations, ultrasonic power, and extraction
Saowapa Chumanee, Jirawan Thunta, Ruchira Khoomsab, Chanakan Winyakul   +3 more
openaire   +1 more source

DataSheet1_Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder.PDF

, 2021
Background and Purpose:Mitragyna speciosa extract and kratom alkaloids decrease alcohol consumption in mice at least in part through actions at the δ-opioid receptor (δOR).
Arryn T. Blaine (11641072), Richard M. van Rijn (9852373), Alexander R. French (11641069), Anna M. Gutridge (9852364), Márk Szabó (11641081), Soumen Chakraborty (343228), Jinling Yuan (11641078), Quinten H. Royer (11641075), Haoyue Cui (3159117), Balazs R. Varga (11641063), Elizabeth S. Rhoda (11641066), Robert J. Cassell (7522568), Susruta Majumdar (1312416)   +12 more
core   +1 more source

Kratom (Mitragyna speciosa) in cancer chemoprevention – A provocative functional food perspective

Journal of Agriculture and Food Research
The increasing interest in natural products for cancer prevention has led to a provocative exploration of Kratom (Mitragyna speciosa) as a potential chemopreventive functional food.
Happy Kurnia Permatasari, Dian Nugrahenny, Bayu Lestari, Rani Wardani Hakim, Zulkarnain Zulkarnain, Muhammad Anshory, Fahrul Nurkolis   +6 more
doaj   +1 more source

Alkaloid Profiles and Activity in Different Strains

Natural Product Communications, 2018
Mitragyna speciosa (K.) H. (Kratom) is a tree that possesses stimulant and opioid-like analgesic effects, and is indigenous to Southeast Asia and Indochina, where it has seen widespread use for hundreds of years.
Luisa Boffa, Corrado Ghè, Alessandro Barge, Giampiero Muccioli, Giancarlo Cravotto   +4 more
doaj   +1 more source

Insights into the alteration of vaginal microbiota and metabolites in pregnant woman with preterm delivery: prospective cohort study

Frontiers in Cellular and Infection Microbiology
Disruptions in vaginal microbiota and metabolites during pregnancy may be the most important risk factor for preterm delivery, thus the difference in vaginal microbiota and metabolites between women who subsequently delivered at term and who eventually ...
Lihua Wang, Jun Zhang, Mengjun Zhang, Zhimin Xu, Yijing Zheng, Bingqing Lv, Mian Pan   +6 more
doaj   +1 more source

Molecular interactions and behavior of kratom alkaloids-mitragynine, 7-hydroxymitragynine, and mitragynine pseudoindoxylin DPPC lipid bilayers: a molecular dynamics simulation study. [PDF]

Kratom (Mitragyna speciosa), a tropical plant native to Southeast Asia, has gained global attention for its potential therapeutic effects, particularly as an alternative to classical opioids for pain management and opioid withdrawal.
Mohd Zubri, Nur Syahirunelisa
core  

Molecular docking evaluation of the alkaloids at the mu opioid receptor.

, 2020
(A) The docking score of the mitragynine congeners (red), pyran-fused mitragynine congeners (blue), oxindole congeners (white), and the pyran-fused oxindole congeners (gray) normalized to mitragynine.
Alexey V. Zakharov (603924), David G. Strauss (3608954), Rebecca Racz (3586589), Marlene T. Kim (5278202), Keith Burkhart (8525538), Noel Southall (187625), Lidiya Stavitskaya (5278199), Christopher R. Ellis (4420009), Naomi L. Kruhlak (2962803), Edward G. Hawkins (2702308)   +9 more
core   +1 more source

Evaluation of Interactions Between Transient Receptor Potential Vanilloid 1 and Active Constituents Using Molecular Docking

Dubai Medical Journal
Introduction: Pain, whether acute or chronic, imposes huge economic burdens in the societies due to complexities in the signaling pathways that lead to pain.
Sahar Jaffal, Salman Khan, Muhammad Ibrar Khan   +2 more
doaj   +1 more source

MOLECULAR DYNAMICS SIMULATION OF MITRAGYNINE INTERACTIONS WITH DOPAMINE D1 AND D2 RECEPTORS: ASSESSING PSYCHOACTIVE EFFECTS AND THERAPEUTIC POTENTIAL

The therapeutic and psychoactive properties of mitragynine, the primary alkaloid in Mitragyna speciosa (kratom), are well documented, particularly in pain therapeutics.
Khalid, Mohamed Haneif, Mohamad Jamali, Muhamad Arif, Yusoff, Nurul Nadiah, Azmi, Liyana, Mohamed Hanief Khalid, Liyana Azmi, Nurul Nadiah Yusoff, Muhamad Arif Mohamad Jamali   +7 more
core   +1 more source

Cosmeceutical Potential of Mitragyna speciosa (Kratom): Anti-Adipogenic and Antioxidant Properties of Extracts and Mitragynine

Molecules
Kratom (Mitragyna speciosa (Korth.) Havil.) is a medicinal plant containing bioactive alkaloids, notably mitragynine and 7-hydroxymitragynine, which are psychoactive compounds with analgesic and stimulant properties.
Sudthiworarak Kaewchompoo, Prapapan Temkitthawon, Kalyarut Phumlek, Neti Waranuch, Ngamrayu Ngamdokmai, Kornkanok Ingkaninan   +5 more
doaj   +1 more source