Results 91 to 100 of about 76,183,421 (152)

Identification of “Kratom” (Mitragyna speciosa) Alkaloids in Commercially Available Products [PDF]

, 2017
“Kratom” is the common name for the botanical mitragyna speciosa. It is a tree native to Southeast Asia in which leaves contain the psychoactive alkaloids mitragynine and 7-hydroxymitragynine. Kratom is often ingested as teas, chewed, or smoked.
Grzymkowski, Julia, Peace, Michelle R, Poklis, Justin   +2 more
core  

Kratom alkaloids and semi-synthetic analogs: Assessment of opioid-like liability profiles [PDF]

The ongoing opioid crisis underscores the urgent need for safer analgesics that mitigate the risks of addiction and overdose associated with traditional opioids.
Zuarth Gonzalez, Julio David
core  

Interactions of kratom alkaloids–mitragynine, 7-hydroxymitragynine, and mitragynine pseudoindoxyl with lipid bilayers: a molecular dynamics study [PDF]

Kratom, a plant native to Southeast Asia, has gained attention as a potential alternative to opioids for pain relief and managing withdrawal symptoms.
Amran, Nur Aqasyah, Awal, Asmah Awal, Jusoh, Siti Azma, Mohd Zubri, Nur Syahirunelisa, Weng, Shirley In Siu, Azhar, Nur Alya Amirah   +5 more
core   +1 more source

Discovery of rhynchophylline and mitraphylline in two Thai Mitragyna species and the investigation of their biological activity via opioid gene expression analysis

Scientific Reports
Mitragyna speciosa (Ms), M. diversifolia (Md), M. hirsuta (Mh) and M. rotundifolia (Mr) were investigated for phytochemicals by GC-MS and GC-FID, cytotoxicity and genotoxicity testing by MTT and comet assay, and biological activity examination through ...
Runglawan Sudmoon, Tawatchai Tanee, Warin Wonok, Unchaleeporn Ameamsri, Thomas Liehr, Sakda Daduang, Pornnarong Siripiyasing, Arunrat Chaveerach   +7 more
doaj   +1 more source

Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for <i>μ</i>-Opioid Receptor and Opioid-Like Behavioral Effects in Rats. [PDF]

J Pharmacol Exp Ther, 2021
Obeng S, Wilkerson JL, León F, Reeves ME, Restrepo LF, Gamez-Jimenez LR, Patel A, Pennington AE, Taylor VA, Ho NP, Braun T, Fortner JD, Crowley ML, Williamson MR, Pallares VLC, Mottinelli M, Lopera-Londoño C, McCurdy CR, McMahon LR, Hiranita T.   +19 more
europepmc   +1 more source

Quantitative analysis of 7-hydroxymitragynine in commercial kratom products and its stability under chemical and physiological conditions

Phytochemistry
7-Hydroxymitragynine (7-OH), a minor alkaloid in kratom (Mitragyna speciosa (Korth.) Havil.) (Rubiaceae) and an active metabolite of mitragynine, is a critical transient precursor to mitragynine pseudoindoxyl, which exhibits >2-fold μ-opioid receptor-biased agonism and improved isoform selectivity relative to its precursors.
Bharathi Avula, Syed Kashif Ali, Kiran K. Tatapudi, Pankaj Pandey, Lochana Cheepilla, Islam Husain, Shabana I. Khan, Kumar Katragunta, Zulfiqar Ali, Ikhlas A. Khan, Amar G. Chittiboyina   +10 more
openaire   +2 more sources

Determination of Alkaloids in Mitragyna speciosa (Kratom) Raw Materials and Dietary Supplements by HPLC-UV: Single-Laboratory Validation, First Action 2017.14

, 2018
The AOAC Expert Review Panel (ERP) approved a method for the quantitation of alkaloids in Mitragyna speciosa for consideration as First Action Official MethodSM status.
Paula N Brown, Elizabeth M Mudge
core   +1 more source

Prediksi Profil Farmakokinetik dan Toksisitas Senyawa Aktif Ekstrak Daun Kratom (Mitragyna speciosa) Secara In Silico Menggunakan pkCSM dan SwissADME [PDF]

The kratom plant (Mitragyna speciosa) has several beneficial pharmacological effects in humans. The pharmacokinetic profiles of secondary metabolites from kratom leaf extract were examined.
anjas, Anjas Wilapangga, Nia marlina Kurnia, Mokhamad Mahroji, Arif Hidayat   +3 more
core  

DEA moves to classify substance found in kratom plant to Schedule I

The U.S. Drug Enforcement Administration (DEA) this month announced its intent to place 7‐hydroxymitragynine (7‐OH) and three of its synthetic derivatives temporarily into Schedule I under the Controlled Substances Act, citing a public health threat ...
Gary Enos
core   +1 more source

Correction to "Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for <i>μ</i>-Opioid Receptor and Opioid-Like Behavioral Effects in Rats". [PDF]

J Pharmacol Exp Ther, 2022
europepmc   +1 more source