Results 91 to 100 of about 824 (158)

Synthesis of Analogues Based on the Opioid Alkaloid Mitragynine [PDF]

, 2010
Opioid analgesics such as morphine and its derivatives are the most frequently prescribed narcotics for the treatment of severe and chronic pain. Among other side effects caused by the administration of these opioid analgesics, physical dependence and ...
Arribas, Marco A
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Potensi Farmakologi Tanaman Kratom (Mitragyna speciosa Korth.): Review [PDF]

Indonesia sebagai negara tropis memiliki keragaman hayati yang melimpah, termasuk tanaman kratom (Mitragyna speciosa Korth.) yang dikenal memiliki aktivitas farmakologis potensial.
Purwaniati, Purwaniati, Suryanti, Wulan Maulani, Sutrisno, Entris   +2 more
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Interactive Effects of <i>µ</i>-Opioid and Adrenergic-<i>α</i> ₂ Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine. [PDF]

J Pharmacol Exp Ther, 2022
Obeng S, Leon F, Patel A, Zuarth Gonzalez JD, Chaves Da Silva L, Restrepo LF, Gamez-Jimenez LR, Ho NP, Guerrero Calvache MP, Pallares VLC, Helmes JA, Shiomitsu SK, Soto PL, McCurdy CR, McMahon LR, Wilkerson JL, Hiranita T.   +16 more
europepmc   +1 more source

An exploratory study of the safety profile and neurocognitive function after single doses of mitragynine in humans [PDF]

© 2024 The Author(s). This is an open access article under the Creative Commons Attribution Non-Commercial No-Derivatives CC BY-NC-ND licence, https://creativecommons.org/licenses/by-nc-nd/4.0/Rationale Despite the growing scientific interest on ...
Bersani, Giuseppe, Cavarra, Mauro, Corazza, Ornella, Kuypers, Kim P. C., Paci, Riccardo, Pasquini, Massimo, Prevete, Elisabeth, Ramaekers, Johannes G., Reckweg, Johannes T., Ritscher, Sabrina, Theunissen, Eef L., Toennes, Stefan W.   +11 more
core   +3 more sources

Treatment of obsessive compulsive disorder and Kratom dependence with buprenorphine and supportive care [PDF]

Kratom is an herbal product derived from Mitragyna speciosa which, depending on the dose, has stimulant and opioid-like effects and is increasingly being used recreationally to self-medicate symptoms of anxiety and depression.
Ajewole, Oluwatobi, Picior, Mihai, Roberts, Emmert, Teixeira, Filipa   +3 more
core   +2 more sources

Correction to "Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for <i>μ</i>-Opioid Receptor and Opioid-Like Behavioral Effects in Rats". [PDF]

J Pharmacol Exp Ther, 2022
europepmc   +1 more source

Analysis Of Gas Station Drugs Using Gas Chromatography Mass Spectrometry And Fourier Transform Infrared Spectroscopy [PDF]

Gas stations and head shops are a seemingly safe and legal marketplace for drug purchase. However, although marketed as dietary supplements or cognitive enhancers, the products sold there have been known to contain psychoactive substances which may be
Joos, Megan
core   +1 more source

Mitragynine and 7-hydroxymitragynine: In vitro blood-brain barrier permeability studies

Frontiers in Cellular Neuroscience, 2016
Mohd Uzid Mahathir, Hanapi Nur Aziah, Mansor Sharif Mahsufi, Yusof Siti Rafidah   +3 more
openaire   +1 more source

Validation and application of a liquid chromatography-tandem mass spectrometry method for mitragynine in postmortem blood and liver [PDF]

, 2023
Kliewer, Rachel Susanne
core  

In Silico Assessment of the ADMET Properties of 7-Hydroxymitragynine and its Interaction with Human Serum Albumin and 1-Acid Glycoprotein

Biointerface Research in Applied Chemistry
Mitragyna speciosa (kratom) is a psychoactive plant native to Southeast Asia that is traditionally used for pain relief, increased physical endurance, and as a muscle relaxant. Its most potent alkaloid, 7-hydroxymitragynine (7-OH-MTG), acts on the µ-opioid receptor, providing analgesic effects.
openaire   +1 more source