Results 1 to 10 of about 4,314 (178)

Environmental Influence on the Untargeted Foliar Metabolome of Naturally Growing Mitragyna Species in Thailand [PDF]

Plant-Environment Interactions
This study investigates the foliar secondary metabolite profiles of four Mitragyna species naturally occurring in Thailand: M. diversifolia, M. hirsuta, M. rotundifolia, and M. speciosa (kratom).
Tushar Andriyas, Nisa Leksungnoen, Chatchai Ngernsaengsaruay, Suwimon Uthairatsamee, Rossarin Tansawat, Pakawat Sirilertpanich   +5 more
doaj   +3 more sources

DNA Barcoding and Chemical Profile Using UHPLC, GC-MS and LC-MS/QTOF of Mitragyna speciosa Variation and Allied Species for Quality Control of Kratom Materials [PDF]

Plants
Kratom (Mitragyna speciosa Korth.) has gained increasing global attention due to its traditional use, psychoactive properties, and emerging therapeutic potential; however, concerns regarding adulteration, substitution, and inconsistent quality of ...
Phunsuk Anantaworasakul, Warunya Arunotayanun, Siripat Chaichit, Suthiwat Khamnuan, Chatchai Ngernsaengsaruay, Chuda Chittasupho, Nisa Leksungnoen, Mingkwan Na Takuathung, Ruedeemars Yubolphan, Apisada Jiso, Tachpon Techarang, Aekkhaluck Intharuksa   +11 more
doaj   +2 more sources

In Vitro and in Vivo Effects of Three Different Mitragyna speciosa Korth Leaf Extracts on Phase II Drug Metabolizing Enzymes—Glutathione Transferases (GSTs)

Molecules, 2010
In the present study, we investigate the effects of three different Mitragyna speciosa extracts, namely methanolic, aqueous and total alkaloid extracts, on glutathione transferase-specific activity in male Sprague Dawley rat liver cytosol in vitro and in
Juzaili Azizi, Mohd Nizam Mordi, Surash Ramanathan   +2 more
exaly   +3 more sources

Evaluation of Antioxidant and Antibacterial Activities of Aqueous, Methanolic and Alkaloid Extracts from Mitragyna Speciosa (Rubiaceae Family) Leaves

Molecules, 2009
Studies on the antioxidant and antimicrobial activities of Mitragyna speciosa leaf extracts are lacking. In this study the antioxidant properties of water, methanolic and alkaloid M.
Suhanya Parthasarathy, Surash Ramanathan, Sreenivasan Sasidharan   +2 more
exaly   +3 more sources

Discovery of rhynchophylline and mitraphylline in two Thai Mitragyna species and the investigation of their biological activity via opioid gene expression analysis [PDF]

Scientific Reports
Mitragyna speciosa (Ms), M. diversifolia (Md), M. hirsuta (Mh) and M. rotundifolia (Mr) were investigated for phytochemicals by GC-MS and GC-FID, cytotoxicity and genotoxicity testing by MTT and comet assay, and biological activity examination through ...
Runglawan Sudmoon, Tawatchai Tanee, Warin Wonok, Unchaleeporn Ameamsri, Thomas Liehr, Sakda Daduang, Pornnarong Siripiyasing, Arunrat Chaveerach   +7 more
doaj   +2 more sources

Precipitated withdrawal with kratom use following naltrexone administration [PDF]

Mental Health Clinician, 2023
Kratom is an herbal supplement with reports of use for natural pain relief or treatment of opioid withdrawal symptoms. Kratom has metabolites that bind to and agonize mu-opioid receptors similar to opiate medications.
Jarka Courtney PharmD, BCPS, BCPP, Gregoire Kelsey PharmD, BCCCP   +1 more
doaj   +1 more source

Mitragyna speciosa as a Potential Substitute Therapy in Opioid Dependence: A Case Report

Pharmaceutical Sciences and Research, 2022
Preclinical data have consistently suggested the pharmaceutical potential of kratom (Mitragyna speciosa), including as a substitute therapy in opioid dependence.
Karniza Khalid, Jason S.K. Wong, Ruzita Jamaluddin   +2 more
doaj   +1 more source

Mitragyna Species as Pharmacological Agents: From Abuse to Promising Pharmaceutical Products

Life, 2022
Mitragyna is a genus belonging to the Rubiaceae family and is a plant endemic to Asia and Africa. Traditionally, the plants of this genus were used by local people to treat some diseases from generation to generation.
Islamudin Ahmad, Wisnu Cahyo Prabowo, Muhammad Arifuddin, Jaka Fadraersada, Niken Indriyanti, Herman Herman, Reza Yuridian Purwoko, Firzan Nainu, Anton Rahmadi, Swandari Paramita, Hadi Kuncoro, Nur Mita, Angga Cipta Narsa, Fajar Prasetya, Arsyik Ibrahim, Laode Rijai, Gemini Alam, Abdul Mun’im, Sukanya Dej-adisai   +18 more
doaj   +1 more source

The Mitragyna speciosa (Kratom) Genome: a resource for data-mining potent pharmaceuticals that impact human health

G3: Genes, Genomes, Genetics, 2021
Mitragyna speciosaM.
Julia Brose, Kin H Lau, Thu Thuy Thi Dang, John P Hamilton, Lívia do Vale Martins, Britta Hamberger, Bjoern Hamberger, Jiming Jiang, Sarah E O’Connor, C Robin Buell   +9 more
doaj   +1 more source

Differentiation of Mitragyna speciosa, a narcotic plant, from allied Mitragyna species using DNA barcoding-high-resolution melting (Bar-HRM) analysis

Scientific Reports, 2021
Mitragyna speciosa (Korth.) Havil. [MS], or “kratom” in Thai, is the only narcotic species among the four species of Mitragyna in Thailand, which also include Mitragyna diversifolia (Wall. ex G. Don) Havil. [MD], Mitragyna hirsuta Havil.
Chayapol Tungphatthong, Santhosh Kumar J. Urumarudappa, Supita Awachai, Thongchai Sooksawate, Suchada Sukrong   +4 more
doaj   +1 more source