Results 1 to 10 of about 859 (118)

Rigorous Biogenetic Network for a Group of Indole Alkaloids Derived from Strictosidine

Molecules, 2008
: Strictosidine, the precursor of more than 2,500 indole alkaloids, was isolated from four species of three plant families. By searching the Dictionary of Natural Products on DVD it was found that about 150 indole alkaloids were obtained from the same ...
László F Szabó
exaly   +3 more sources

A Systematic Review of Analytical Methods for Quantification of Natural Indole Alkaloids from Catharanthus and Rauvolfia Species [PDF]

Research Journal of Pharmacognosy, 2023
Indole alkaloids are a class of alkaloids enclosing a structural moiety of indole; numerous indole alkaloids also comprise isoprene groups and are thus named terpene indole or secologanin tryptamine alkaloids and have more than 4100 identified diverse ...
Lakshmipriya Murugesan, Kokilambigai Shanmugaramasamy*, Ilango Kaliappan   +2 more
doaj   +1 more source

Improved protein glycosylation enabled heterologous biosynthesis of monoterpenoid indole alkaloids and their unnatural derivatives in yeast

Metabolic Engineering Communications, 2023
With over 3000 reported structures, monoterpenoid indole alkaloids (MIAs) constitute one of the largest alkaloid groups in nature, including the clinically important anticancer drug vinblastine and its semi-synthetic derivatives from Catharanthus roseus (
Mohammadamin Shahsavarani, Joseph Christian Utomo, Rahul Kumar, Melina Paz-Galeano, Jorge Jonathan Oswaldo Garza-García, Zhan Mai, Dae-Kyun Ro, Yang Qu   +7 more
doaj   +1 more source

A microbial supply chain for production of the anti-cancer drug vinblastine [PDF]

, 2022
International audienceAbstract Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary metabolites with many medicinal properties, including the essential anti-cancer therapeutics vinblastine and vincristine 1 .
Adhikari, K., Arsovska, D., Baidoo, E., Carrasquer-Alvarez, E., Chan, L., Chen, L., Christensen, H., Courdavault, V., D’Ambrosio, V., Giannakou, K., Gudich, O., Haidar, A., Hansen, L., Jensen, M., Jørgensen, M., Keasling, J., Kristensen, M., Laloux, M., Lassen, L., Lehka, B., Nallapareddy, S., O’Connor, S., Petzold, C., Rubaszka, P., Schrübbers, L., Stander, E., Sudarsan, S., Viehrig, K., Wulff, T., Zhang, J.   +29 more
core   +2 more sources

The ORCA2 transcription factor plays a key role in regulation of the terpenoid indole alkaloid pathway [PDF]

, 2013
Background: The terpenoid indole alkaloid (TIA) pathway leads to the production of pharmaceutically important drugs, such as the anticancer compounds vinblastine and vincristine.
Gibson, Susan, Leopold, Alex, Li, Chun, Sander, Guy, Shanks, Jacqueline, Shanks, Jacqueline, Zhao, Le   +6 more
core   +3 more sources

Transcriptome analysis of stem wood of Nothapodytes nimmoniana (Graham) Mabb. identifies genes associated with biosynthesis of camptothecin, an anti-carcinogenic molecule [PDF]

, 2016
Camptothecin (CPT), a monoterpene indole alkaloid, is a potent inhibitor of DNA topoisomerase I and has applications in treating ovarian, small lung and refractory ovarian cancers. Stem wood tissue of Nothapodytes nimmoniana (Graham) Mabb.
Kumar, Sanjay, Manunatha, BL, Nataraja, KN, Ravikanth, G, Shankar , R, Singh, HR, Uma Shaanker, R   +6 more
core   +1 more source

Strictosidine activation in Apocynaceae: towards a "nuclear time bomb"? [PDF]

, 2010
Background The first two enzymatic steps of monoterpene indole alkaloid (MIA) biosynthetic pathway are catalysed by strictosidine synthase (STR) that condensates tryptamine and secologanin to form strictosidine and by strictosidine β-D-glucosidase (SGD ...
Guirimand Grégory, Courdavault Vincent, Lanoue Arnaud, Mahroug Samira, Guihur Anthony, Blanc Nathalie, Giglioli-Guivarc'h Nathalie, St-Pierre Benoit, Burlat Vincent   +8 more
core   +1 more source

Identification of iridoid glucoside transporters in Catharanthus roseus [PDF]

, 2017
Monoterpenoid indole alkaloids (MIAs) are plant defense compounds and high-value pharmaceuticals. Biosynthesis of the universal MIA precursor, secologanin, is organized between internal phloem-associated parenchyma (IPAP) and epidermis cells ...
Colinas Martinez, Maite, Fuller, Victoria L, Goossens, Alain, Halkier, Barbara A, Larsen, Bo, O'Connor, Sarah E, Payne, Richard, Pollier, Jacob, Schweizer, Fabian, Van Moerkercke, Alex   +9 more
core   +2 more sources

LAP3, a novel plant protein required for pollen development, is essential for proper exine formation [PDF]

, 2009
We isolated lap3-1 and lap3-2 mutants in ascreen for pollen that displays abnormal stigma binding.Unlike wild-type pollen, lap3-1 and lap3-2 pollen exine isthinner, weaker, and is missing some connections betweentheir roof-like tectum structures.
Carlson, Ann L, Dobritsa, Anna A., Hammond, Adam, Nishikawa, Shuh-Ichi, Preuss, Daphne, Sumner, Lloyd W, Swanson, Rob, Urbanczyk-Wochniak, Ewa   +7 more
core   +2 more sources

Indolo[2,3-a]quinolizidines and derivatives: Bioactivity and asymmetric Synthesis [PDF]

, 2016
Corynantheine alkaloids with a tetracyclic indole[2,3-a]-quinolizidine motif are an important issue in academia and in the life science industries due to their broad bioactivity profile.
Espadinha, Margarida, Pérez Bosch, Maria, Santos, Maria M. M.   +2 more
core   +1 more source