Results 71 to 80 of about 76,183,421 (152)

Synthesis, Characterization And Analgesic Activity Of Mitragynine Analogues [PDF]

, 2015
Mitragyna speciosa contains many alkaloids and mitragynine (MG) is its most abundant alkaloid and has received much attention due to its analgesic property.
Ramlee, Nurul Izzati
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Acute, Sublethal, and Developmental Toxicity of Kratom (Mitragyna speciosa Korth.) Leaf Preparations on Caenorhabditis elegans as an Invertebrate Model for Human Exposure

, 2022
Kratom (Mitragyna speciosa Korth.) is a tree native to Southeast Asia with stimulant and opioid-like effects which has seen increased use in Europe and North America in recent years.
Veltri, Charles A., Charles A. Veltri, Hughes, Samantha; id_orcid, van de Klashorst, David, David van de Klashorst, Oliver Grundmann, Hughes, Samantha, Grundmann, Oliver, Samantha Hughes   +8 more
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Effects of Nutrient Fertility on Growth and Alkaloidal Content in Mitragyna speciosa (Kratom)

Frontiers in Plant Science, 2020
Leaves harvested from the Southeast Asian tree Mitragyna speciosa (kratom) have a history of use as a traditional ethnobotanical source of medicine to combat fatigue, improve work productivity, and to reduce opioid-related withdrawal symptoms.
Mengzi Zhang, Abhisheak Sharma, Francisco León, Bonnie Avery, Bonnie Avery, Roger Kjelgren, Christopher R. McCurdy, Christopher R. McCurdy, Brian J. Pearson   +8 more
doaj   +1 more source

Reported associations between kratom and seizures: a systematic review

Frontiers in Pharmacology
Statement of purpose, innovation or hypothesisKratom, derived from the leaves of the plant Mitragyna speciosa, is an herbal supplement that has been used medically and recreationally for centuries, but has recently gained popularity in the United States ...
Toby Turla, Grayson Abele, My Hua, Dennis Paustenbach   +3 more
doaj   +1 more source

Phytochemical Characterization of the Leaves of Grown in USA

Natural Product Communications, 2009
Mitragyna speciosa (Rubiaceae) has traditionally been used in the tropical regions of Asia, Africa and Indonesia as a substitute for opium. Indole alkaloids are the most common compounds that have been isolated.
Francisco León, Eman Habib, Jessica E. Adkins, Edward B. Furr, Christopher R. McCurdy, Stephen J. Cutler   +5 more
doaj   +1 more source

Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions [PDF]

, 2020
The safety and efficacy of kratom (Mitragyna speciosa) for treatment of pain is highly controversial. Kratom produces more than 40 structurally related alkaloids, but most studies have focused on just two of these, mitragynine and 7-hydroxymitragynine ...
Raja, Huzefa A., Cech, Nadja B., Todd, Daniel A., Graf, Tyler, NC DOCKS at The University of North Carolina at Greensboro, Oberlies, Nicholas   +5 more
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Case Report: Cannabis and kratom-induced self-amputation of ears and penis

Frontiers in Psychiatry
This report describes the case of a 31-year-old male lumberjack with severe self-inflicted injuries, including the amputation of both auricles and the penis, under the influence of cannabinoids, mitragynine, and 7-hydroxymitragynine.
Marek Broul, Marek Broul, Marek Broul, Xenia Rudenko, Adam Bajus, Jiří Král, Dan Mwemena Kyenge, Zdenka Staňková, Jakub Albrecht, Jakub Albrecht   +9 more
doaj   +1 more source

Development of transcriptomic resources for interrogating the biosynthesis of monoterpene indole alkaloids in medicinal plant species.

PLoS ONE, 2012
The natural diversity of plant metabolism has long been a source for human medicines. One group of plant-derived compounds, the monoterpene indole alkaloids (MIAs), includes well-documented therapeutic agents used in the treatment of cancer (vinblastine,
Elsa Góngora-Castillo, Kevin L Childs, Greg Fedewa, John P Hamilton, David K Liscombe, Maria Magallanes-Lundback, Kranthi K Mandadi, Ezekiel Nims, Weerawat Runguphan, Brieanne Vaillancourt, Marina Varbanova-Herde, Dean Dellapenna, Thomas D McKnight, Sarah O'Connor, C Robin Buell   +14 more
doaj   +1 more source

The rise of novel, semi-synthetic 7-hydroxymitragnine products. [Letter]

Products containing the psychoactive botanical, Mitragyna speciosa, have transformed from simple leaf powders into an array of products, falling under the broad umbrella of ‘kratom’. Whole-leaf products contain consistent concentrations of kratom’s major
Sharma, Abhisheak, Boyer, Edward W, Grundmann, Oliver, McCurdy, Christopher R, Smith, Kirsten E   +4 more
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Validation and application of a liquid chromatography-tandem mass spectrometry method for mitragynine in postmortem blood and liver [PDF]

, 2023
Kratom is a tree originating in Southeast Asia, and has a history of usage among farmers. The leaves of the tree were chewed and used by farmers as a stimulant in order to work long days.
Kliewer, Rachel Susanne
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