Studies on the phase I and II metabolism and the toxicological analysis of the alkaloids of the herbal drug of abuse Mitragyna speciosa Korth. (Kratom) using gas chromatography-mass spectrometry and liquid chromatography coupled to low- and high-resolution linear ion trap mass spectrometry [PDF]
, 2011 In the presented studies, the herbal drug Kratom (Mitragyna speciosa) was investigated regarding its metabolism and its toxicological analysis in rat and human urine.
Philipp, Anika-Anina
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PLoS ONE, 2012 The natural diversity of plant metabolism has long been a source for human medicines. One group of plant-derived compounds, the monoterpene indole alkaloids (MIAs), includes well-documented therapeutic agents used in the treatment of cancer (vinblastine,
Elsa Góngora-Castillo +14 more
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Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions [PDF]
, 2020 The safety and efficacy of kratom (Mitragyna speciosa) for treatment of pain is highly controversial. Kratom produces more than 40 structurally related alkaloids, but most studies have focused on just two of these, mitragynine and 7-hydroxymitragynine ...
Cech, Nadja B. +5 more
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A Study of the Kratom Alkaloids and Their Binding to the μ-Opioid Receptor [PDF]
, 2019 Kratom, a plant commonly found in southeast Asia, has traditionally been used for medicinal treatments. Recently, however, the popularity of the drug has significantly increased due to its euphoric effects, leading to it being used as an alternative to ...
Chamblee, Reba Elizabeth Ann
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Clinical pharmacokinetic assessment of kratom (Mitragyna speciosa), a botanical product with opioid-like effects, in healthy adult participants [PDF]
, 2022 Increasing use of the botanical kratom to self-manage opioid withdrawal and pain has led to increased kratom-linked overdose deaths. Despite these serious safety concerns, rigorous fundamental pharmacokinetic knowledge of kratom in humans remains lacking.
Cech, Nadja B. +3 more
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The Analysis of Commercially Available Kratom Products in Richmond, Virginia [PDF]
, 2022 Kratom is a novel psychoactive substance that has gained popularity within the past ten years. Originating from Southeast Asia, the leaves of the Mitragyna speciosa tree contain two principal alkaloids, mitragynine and 7-hydroxymitragynine, that play a ...
Alves, Emanuele A +3 more
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Metabolism And Pharmacokinetics In The Development Of New Therapeutics For Cocaine And Opioid Abuse [PDF]
, 2012 Cocaine and opioid abuse are a major public health concern and the cause of significant morbidity and mortality worldwide. The development of effective medication for cocaine and opioid abuse is necessary to reduce the impact of this issue upon the ...
Vuppala, Pradeep Kumar
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In-Utero effects of the crude ethanolic extract of the leaves of mitragyna speciosa on neural tube formation in rats [PDF]
, 2010 The developmental effects of in-utero administration of the crude ethanolic extract of the leaves of itragyna speciosa (MS) on neural tube in fetal rats were investigated.
Abd Kadir, Siti Nur Sharida +4 more
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Kratom (Mitragyna speciosa) in cancer chemoprevention – A provocative functional food perspective
Journal of Agriculture and Food ResearchThe increasing interest in natural products for cancer prevention has led to a provocative exploration of Kratom (Mitragyna speciosa) as a potential chemopreventive functional food.
Happy Kurnia Permatasari +6 more
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Alkaloid Profiles and Activity in Different Strains
Natural Product Communications, 2018 Mitragyna speciosa (K.) H. (Kratom) is a tree that possesses stimulant and opioid-like analgesic effects, and is indigenous to Southeast Asia and Indochina, where it has seen widespread use for hundreds of years.
Luisa Boffa +4 more
doaj +1 more source