Results 21 to 30 of about 1,701 (157)
Separations, 2022 Mitragynine and its congeners are one of the major phytoconstituents present in Mitragyna speciosa Korth. (ketum) leaves and a well-known factor that contributes to ketum’s pharmacological activities.
Thiruventhan Karunakaran +5 more
doaj +1 more source
Directed Biosynthesis of Mitragynine Stereoisomers
, 2023 Mitragyna speciosa (“kratom”) is used as a natural remedy for pain and management of opioid dependence. The pharmacological properties of kratom have been linked to a complex mixture of monoterpene indole alkaloids, most notably mitragynine.
Satya Swathi Nadakuduti (5946059) +9 more
core +1 more source
7-Hydroxymitragynine is an Active Metabolite of Mitragynine and a Key Mediator of its Analgesic Effects [PDF]
, 2019 Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction.
Rajendra, Uprety +12 more
core +2 more sources
Investigation Of In Vitro Permeation Of Mitragynine Through The Skin [PDF]
, 2023 Mitragynine is an alkaloid isolated from the leaves of the Mitragyna speciosa plant and has been traditionally consumed in the form of tea concoctions. Recent studies theorised mitragynine to be a potential candidate for pain relief and the treatment of ...
Sim, Yee Shan
core +1 more source
Frontiers in Pharmacology, 2021 Background: Kratom (Mitragyna speciosa Korth), a popular opioid-like plant holds its therapeutic potential in pain management and opioid dependence. However, there are growing concerns about the safety or potential toxicity risk of kratom after prolonged
Thenmoly Damodaran +4 more
doaj +1 more source
PLoS ONE, 2023 Regular use of Thai kratom has been linked to reduced blood triglyceride levels and body mass index (BMI) in healthy individuals. We analyzed Green Thai Kratom (GTK) and Red Thai Kratom (RTK) to investigate their effects on pancreatic digestive enzymes ...
Atikarn Janthongkaw +7 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Multiorgan toxicities have been extensively reported in kratom (Mitragyna speciosa Korth) users in Western countries but not in Southeast Asia. Existing literature argued that this discrepancy may be due to underreporting of kratom-related toxicity cases
Mohammad Farris Iman Leong Bin Abdullah +1 more
doaj +1 more source
Transient Sensorineural Hearing Loss and Rhabdomyolysis, Associated With Chronic Kratom Use. [PDF]
Case Rep OtolaryngolKratom is a colloquial name for products derived from the mitragyna plant species originating in Southeast Asia and now widely available in the United States as a dietary supplement. Kratom is used primarily for self‐management of pain, anxiety, and opioid withdrawal due to its partial agonist activity on mu opioid receptors, as well as other ...
Watanabe H, Zhang K, Shapiro Y.
europepmc +2 more sources
Mitragyna Species as Pharmacological Agents: From Abuse to Promising Pharmaceutical Products
Life, 2022 Mitragyna is a genus belonging to the Rubiaceae family and is a plant endemic to Asia and Africa. Traditionally, the plants of this genus were used by local people to treat some diseases from generation to generation.
Islamudin Ahmad +18 more
doaj +1 more source
Discovery of a Plant Pictet–Spenglerase With R‐Stereoselectivity
Angewandte Chemie, Volume 138, Issue 20, 11 May 2026.Strictosidine synthases (STRs) are plant Pictet–Spenglerases catalyzing the coupling of a secoiridoid with tryptamine. All previously characterized strictosidine synthases are strictly S‐selective. Here, we report the discovery of Epi‐STR, an R‐selective STR ortholog from the medicinal plant Pogonopus speciosus.
Clara Morweiser +3 more
wiley +2 more sources