Results 31 to 40 of about 1,701 (157)

In silico investigation of mitragynine and 7-hydroxymitragynine metabolism

BMC Research Notes, 2019
Objective Mitragynine is the main active compound of Mitragyna speciose (Kratom in Thai). The understanding of mitragynine derivative metabolism in human body is required to develop effective detection techniques in case of drug abuse or establish an ...
Taweetham Limpanuparb, Rattha Noorat, Yuthana Tantirungrotechai   +2 more
doaj   +1 more source

Testing the Efficacy of a Prototype That Combines Ultrasound and Pulsed Electric Field for Extracting Valuable Compounds from Mitragyna speciosa Leaves

AgriEngineering, 2023
This work aimed to test the efficacy of an ultrasound (US) and pulsed electric field (PEF) apparatus to extract mitragynine from dried Mitragyna speciosa cv. Karn Dang leaves. Four modes of the device were tested: PEF, US, US + PEF, and PEF + US, and the
Raweeroj Jintawiwat, Natnakorn Punamorntarakul, Rossakornpat Hirunyasiri, Parkpoom Jarupoom, Tanachai Pankasemsuk, Supakiat Supasin, Arthitaya Kawee-ai   +6 more
doaj   +1 more source

Interactive Effects of -Opioid and Adrenergic- Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine

, 2022
The primary kratom alkaloid mitragynine is proposed to act through multiple mechanisms, including actions at -opioid receptors (MORs) and adrenergic- receptors (A Rs), as well as conversion in vivo to a MOR agonist metabolite (i.e., 7-hydroxymitragynine)
Patel, Avi, Zuarth Gonzalez, Julio D, Obeng, Samuel, Gamez-Jimenez, Lea R, Restrepo, Luis F, Chaves Da Silva, Lucas, Leon, Francisco, Ho, Nicholas P   +7 more
core   +1 more source

A Critical Review of the Neuropharmacological Effects of Kratom: An Insight from the Functional Array of Identified Natural Compounds

Molecules, 2023
Kratom (Mitragyna speciosa Korth. Havil) has been considered a narcotic drug for years, barred by the law in many parts of the world, while extensive research over the past few decades proves its several beneficial effects, some of which are still in ...
Rahni Hossain, Abida Sultana, Manit Nuinoon, Kunwadee Noonong, Jitbanjong Tangpong, Kazi Helal Hossain, Md Atiar Rahman   +6 more
doaj   +1 more source

Structure of Mitragynine and analogues.

, 2014
Structure of Mitragynine and analogues.
Heming Wei (280453), Jianjun Wu (276191), Mohd Fadzly Amar Jamil (336866), Mohd Ilham Adenan (678492), Philip Wong (73144), Jun Lu (36049), Winston Shim (280454), Mei Lan Tan (678491)   +7 more
core   +1 more source

Accelerated Solvent Extractions (ASE) of Mitragyna speciosa Korth. (Kratom) Leaves: Evaluation of Its Cytotoxicity and Antinociceptive Activity

Molecules, 2021
Mitragyna speciosa Korth (kratom) is known for its psychoactive and analgesic properties. Mitragynine is the primary constituent present in kratom leaves.
Yong Sean Goh, Thiruventhan Karunakaran, Vikneswaran Murugaiyah, Rameshkumar Santhanam, Mohamad Hafizi Abu Bakar, Surash Ramanathan   +5 more
doaj   +1 more source

Synthesis of β‐ and γ‐Carbolinones Through a Fe(III)‐Mediated Radical 6‐Endo‐Trig Cyclization of Indole‐Based Ugi 4‐CR Adducts

European Journal of Organic Chemistry, Volume 29, Issue 38, 13 October 2026.
A practical strategy for synthesizing β‐ and γ‐carbolinones from indole‐based Ugi 4‐CR adducts through an intramolecular radical cyclization using Fe(III)–H species is presented. This approach enables the efficient synthesis of spiro‐carbolinones under mild reaction conditions and demonstrates the effectiveness of secondary radicals in both cyclization
María F. Olvera‐Granados, Luis A. Polindara‐García   +1 more
wiley   +1 more source

Fatal Mitragynine-Associated Toxicity in Canada

, 2018
Mitragynine is amongst the more than 40 natural indole alkaloids derived from the Mitragyna speciosa, or kratom tree, also referred to as ketum. The compound is unique in that it exhibits dose-dependent clinical outcomes with stimulant effects at lower ...
Alfredo E. Walker, Carol Wang
core   +1 more source

Novel Histopathologic Features of Diffuse Blue‐Gray Hyperpigmentation Associated With Kratom Use: A Case Report and Literature Review

Journal of Cutaneous Pathology, Volume 53, Issue 10, Page 887-892, October 2026.
ABSTRACT Background Drug‐induced hyperpigmentation accounts for 10%–20% of acquired pigmentary disorders and can be misdiagnosed for other causes such as melasma, post inflammatory changes, or heavy metal deposition. Kratom (Mitragyna speciosa), a Southeast Asian plant with an opioid‐like profile, has been increasingly used in the United States for ...
Rita Kamoua, Kristen Paradine, Craig A. Rohan, Mary McDaniel, Diane Perkins   +4 more
wiley   +1 more source

Role of histone regulations and modifications in cognitive functions of mitragynine (a major indole alkaloid of mitragyna speciosa) [PDF]

, 2021
Introduction: Previous researchers reveal that drug addiction does alter cognitive mechanisms in humans and bring changes to cognitive behaviour. Experimental studies involving addiction of drugs like heroin, cocaine and many others have shown to have
Radhakrishnan, Sonia Dhiya
core   +1 more source