Results 31 to 40 of about 2,217 (207)
Separations, 2022 Mitragynine and its congeners are one of the major phytoconstituents present in Mitragyna speciosa Korth. (ketum) leaves and a well-known factor that contributes to ketum’s pharmacological activities.
Thiruventhan Karunakaran +5 more
doaj +1 more source
Pharmacokinetics of mitragynine in man
Drug Design, Development and Therapy, 2015 Kratom, known botanically as Mitragyna speciosa (Korth.), is an indigenous tree in Southeast Asia. Kratom is currently easily available worldwide via special shops and the Internet to use as a drug of abuse, opioid alternative, or pain killer. So far, the pharmacokinetics of this plant has been studied only in animals, and there is no such study in ...
Trakulsrichai S +7 more
openaire +6 more sources
Assessment of the potential of novel and classical opioids to induce respiratory depression in mice
British Journal of Pharmacology, Volume 180, Issue 24, Page 3160-3174, December 2023., 2023 Abstract Background and Purpose Opioid‐induced respiratory depression limits the use of μ‐opioid receptor agonists in clinical settings and is the main cause of opioid overdose fatalities. The relative potential of different opioid agonists to induce respiratory depression at doses exceeding those producing analgesia is understudied despite its ...
Rob Hill +9 more
wiley +1 more source
Kratom Consumption can be Addictive and have Adverse Health Effects [PDF]
Novelty in Clinical Medicine, 2022 Kratom, also known as herbal speed, is the powdered leaves of the Asian kratom tree (Mitragyna speciosa Korth.). The consumption of kratom powder or kratom tea for diarrhea, inflammation, fever, and pain, but also for anxiety and depression is based on ...
Martin Hofmeister
doaj +1 more source
7‑hydroxymitragynine is an active metabolite of mitragynine and a key mediator of its analgesic effects [PDF]
, 2019 Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction.
Ansonoff, Michael +12 more
core +3 more sources
Biosynthesis of kratom opioids
New Phytologist, Volume 240, Issue 2, Page 757-769, October 2023., 2023 Summary Mitragynine, an analgesic alkaloid from the plant Mitragyna speciosa (kratom), offers a safer alternative to clinical opioids such as morphine, owing to its more favorable side effect profile. Although kratom has been traditionally used for stimulation and pain management in Southeast Asia, the mitragynine biosynthesis pathway has remained ...
Kyunghee Kim +6 more
wiley +1 more source
Herbal highs: review on psychoactive effects and neuropharmacology [PDF]
, 2017 Background: A new trend among users of new psychoactive substances’ the consumption of “herbal highs”: plant parts containing psychoactive substances.
Graziano, S +5 more
core +1 more source
Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression. [PDF]
, 2011 Mitragyna speciosa Korth. leaves have been used for decades as a traditional medicine to treat diarrhea, diabetes and to improve blood circulation by natives of Malaysia, Thailand and other regions of Southeast Asia.
Abdul Rahman, Shamima +6 more
core +1 more source
Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit beta-Arrestin-2. [PDF]
, 2016 Natural products found in Mitragyna speciosa, commonly known as kratom, represent diverse scaffolds (indole, indolenine, and spiro pseudoindoxyl) with opioid activity, providing opportunities to better understand opioid pharmacology.
Borics, Attila +5 more
core +1 more source
Clinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom
Clinical Pharmacology &Therapeutics, Volume 113, Issue 6, Page 1315-1325, June 2023., 2023 Oral formulations prepared from the leaves of the kratom (Mitragyna speciosa) plant are increasingly used for their opioid‐like effects to self‐manage opioid withdrawal and pain. Calls to US poison centers involving kratom exposures increased >50‐fold from 2011–2017, one‐third of which reported concomitant use of kratom with drugs of abuse.
Rakshit S. Tanna +9 more
wiley +1 more source