Results 51 to 60 of about 2,217 (207)

Computational study on the conformations of mitragynine and mitragynaline [PDF]

Journal of Molecular Structure: THEOCHEM, 2010
A conformational search on mitragynine and mitragynaline, natural products isolated from the leaves of Mitragyna speciosa, was performed using the MMFF94s force field and the quantum mechanical B3LYP method. The main difference for the mitragynine conformers is caused by the position of the lone pair of the nitrogen shared by rings 3 and 4 ...
Haining, Liu, Christopher R, McCurdy, Robert J, Doerksen   +2 more
openaire   +2 more sources

SODAS: Surveillance of Drugs of Abuse Study [PDF]

, 2017
Objective: Novel Psychoactive Substance (NPS) as a form of recreational drug use has become increasingly popular. There is a paucity of information with regards the prevalence and clinical sequalae of these drugs.
Bloeck, Felix, Ireland, Alastair, Lowe, David J., Stevenson, Richard, Torrance, Hazel   +4 more
core   +1 more source

Testing the Efficacy of a Prototype That Combines Ultrasound and Pulsed Electric Field for Extracting Valuable Compounds from Mitragyna speciosa Leaves

AgriEngineering, 2023
This work aimed to test the efficacy of an ultrasound (US) and pulsed electric field (PEF) apparatus to extract mitragynine from dried Mitragyna speciosa cv. Karn Dang leaves. Four modes of the device were tested: PEF, US, US + PEF, and PEF + US, and the
Raweeroj Jintawiwat, Natnakorn Punamorntarakul, Rossakornpat Hirunyasiri, Parkpoom Jarupoom, Tanachai Pankasemsuk, Supakiat Supasin, Arthitaya Kawee-ai   +6 more
doaj   +1 more source

The Antidepressant-Like and Analgesic Effects of Kratom Alkaloids are accompanied by Changes in Low Frequency Oscillations but not ΔFosB Accumulation

Frontiers in Pharmacology, 2021
Mitragyna speciosa (“kratom”), employed as a traditional medicine to improve mood and relieve pain, has shown increased use in Europe and North America.
Shoshana Buckhalter, Eric Soubeyrand, Sarah A.E. Ferrone, Duncan J. Rasmussen, Joshua D. Manduca, M. Sameer Al-Abdul-Wahid, Jude A. Frie, Jude A. Frie, Jibran Y. Khokhar, Jibran Y. Khokhar, Tariq A. Akhtar, Melissa L. Perreault, Melissa L. Perreault   +12 more
doaj   +1 more source

Pharmacokinetics and Safety of Mitragynine in Beagle Dogs

Planta Medica, 2020
AbstractMitragynine is the most abundant psychoactive alkaloid derived from the leaves of Mitragyna speciosa (kratom), a tropical plant indigenous to regions of Southeast Asia. Mitragynine displays a moderate affinity to opioid receptors, and kratom is often self-prescribed to treat pain and/or opioid addiction.
Elizabeth A. Maxwell, Tamara I. King, Shyam H. Kamble, Kanumuri Siva Rama Raju, Erin C. Berthold, Francisco León, Bonnie A. Avery, Lance R. McMahon, Christopher R. McCurdy, Abhisheak Sharma   +9 more
openaire   +3 more sources

Two Single-Drug Fatal Intoxications by Mitragynine

Journal of Analytical Toxicology, 2022
Abstract Mitragyna speciosa, a species of plant that is native to Thailand, Malaysia and Southeast Asia, contains two major psychoactive alkaloids: mitragynine and 7-hydroxymitragynine. Pharmacologically, the alkaloids exhibit biphasic effects—at low doses, stimulant effects are realized, while high doses exhibit sedative effects.
George S Behonick, Christina Vu, Larry Czarnecki, Maisie El-Ters, Kevin G Shanks   +4 more
openaire   +2 more sources

Novel Histopathologic Features of Diffuse Blue‐Gray Hyperpigmentation Associated With Kratom Use: A Case Report and Literature Review

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Drug‐induced hyperpigmentation accounts for 10%–20% of acquired pigmentary disorders and can be misdiagnosed for other causes such as melasma, post inflammatory changes, or heavy metal deposition. Kratom (Mitragyna speciosa), a Southeast Asian plant with an opioid‐like profile, has been increasingly used in the United States for ...
Rita Kamoua, Kristen Paradine, Craig A. Rohan, Mary McDaniel, Diane Perkins   +4 more
wiley   +1 more source

Mitragynine attenuates withdrawal syndrome in morphine-withdrawn zebrafish.

PLoS ONE, 2011
A major obstacle in treating drug addiction is the severity of opiate withdrawal syndrome, which can lead to unwanted relapse. Mitragynine is the major alkaloid compound found in leaves of Mitragyna speciosa, a plant widely used by opiate addicts to ...
Beng-Siang Khor, Mohd Fadzly Amar Jamil, Mohamad Ilham Adenan, Alexander Chong Shu-Chien   +3 more
doaj   +1 more source

A Critical Review of the Neuropharmacological Effects of Kratom: An Insight from the Functional Array of Identified Natural Compounds

Molecules, 2023
Kratom (Mitragyna speciosa Korth. Havil) has been considered a narcotic drug for years, barred by the law in many parts of the world, while extensive research over the past few decades proves its several beneficial effects, some of which are still in ...
Rahni Hossain, Abida Sultana, Manit Nuinoon, Kunwadee Noonong, Jitbanjong Tangpong, Kazi Helal Hossain, Md Atiar Rahman   +6 more
doaj   +1 more source

Induction and Analysis of the Alkaloid Mitragynine Content of a Mitragyna speciosa Suspension Culture System upon Elicitation and Precursor Feeding

The Scientific World Journal, 2013
This study aimed to determine the effects of different concentrations and combinations of the phytohormones 2,4-dichlorophenoxy acetic acid (2,4-D), kinetin, 6-benzylaminopurine (BAP), and 1-naphthaleneacetic acid (NAA) on callus induction ...
Nor Nahazima Mohamad Zuldin, Ikram Md. Said, Normah Mohd Noor, Zamri Zainal, Chew Jin Kiat, Ismanizan Ismail   +5 more
doaj   +1 more source