Results 51 to 60 of about 1,701 (157)

Environmental Influence on the Untargeted Foliar Metabolome of Naturally Growing Mitragyna Species in Thailand

Plant-Environment Interactions, Volume 7, Issue 1, February 2026.
ABSTRACT This study investigates the foliar secondary metabolite profiles of four Mitragyna species naturally occurring in Thailand: M. diversifolia, M. hirsuta, M. rotundifolia, and M. speciosa (kratom). Using untargeted gas chromatography–mass spectrometry (GC–MS), 409 secondary volatile metabolites were annotated across the four species.
Tushar Andriyas, Nisa Leksungnoen, Chatchai Ngernsaengsaruay, Suwimon Uthairatsamee, Rossarin Tansawat, Pakawat Sirilertpanich   +5 more
wiley   +1 more source

The Ethanol‐Insoluble Low‐Molecular‐Weight Fraction LEP‐4 Derived From Lentinula edodes Mycelia Extract Attenuates Oxaliplatin‐Evoked Allodynia in Mice

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2026, Issue 1, 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) is an adverse event caused by drugs such as bortezomib, vincristine, paclitaxel, and oxaliplatin (L‐OHP). This condition can lead to the discontinuation of anticancer drug administration and a diminished quality of life, posing a significant clinical problem.
Masanobu Tsubaki, Taira Matsuo, Rie Komori, Tomoya Takeda, Noriaki Nagai, Toshio Morikawa, Shozo Nishida, Anjali Chauhan   +7 more
wiley   +1 more source

Analisis Efek Mitragynine Terhadap Metabolisme Glukosa melalui Uji Toleransi Glukosa (OGTT) dan Uji Toleransi Insulin (ITT) pada Model Tikus Diabetes

Prominentia Medical Journal
Mitragynine adalah alkaloid utama yang terdapat dalam Mitragyna speciosa (kratom) dan dikenal memiliki berbagai aktivitas biologis, termasuk potensi terhadap metabolisme glukosa.
Evi Sylvia Awwalia, RA. Hani Faradis, Devyana Dyah Wulandari, Hotimah Masdan Salim   +3 more
doaj   +1 more source

The 730 nm Picosecond Titanium Sapphire Laser for Treatment of Kratom‐Induced Hyperpigmentation

Lasers in Surgery and Medicine, Volume 57, Issue 5, Page 373-382, July 2025.
ABSTRACT Objectives This case series reports the use of the 730‐nm picosecond titanium‐sapphire laser in the treatment of kratom‐induced hyperpigmentation, a dermatological side effect associated with the use of Mitragyna speciosa, which remains poorly understood. Methods A series of patients with kratom‐induced hyperpigmentation were treated using the
Alanoud A. Alhadyani, Christen Samaan, Girish S. Munavalli   +2 more
wiley   +1 more source

Effects of Mitragynine on Locomotor and Anxiety in Rats Subjected to Restraint Stress [PDF]

, 2010
Mitragyna speciosa is an indigenous tree found in Southeast Asia particularly in Thailand and Malaysia. It is popularly known as ‘kratom’ in Thailand and ‘ketum’ in Malaysia.
Adib Ridzuan, Nurul Raudzah
core   +1 more source

Copper‐Catalyzed Synthesis of C‐2 Substituted Indolin‐3‐Ones and Indolin‐3‐One [4+2] Cycloadducts Through Azide‐Tethered Iodonium Ylides

Asian Journal of Organic Chemistry, Volume 14, Issue 5, May 2025.
Azide‐tethered iodonium ylides under copper catalysis generate metallocarbenes that undergo intramolecular trapping by the azide moiety and generate a reactive C‐acylimine, effectively coupling two nucleophilic centers. This intermediate can be trapped by a wide range of nucleophiles or 1,3‐dienes producing complex indolin‐3‐ones and ...
Israel Najar Guerrero, Zinah Al‐Khateeb, F. G. West   +2 more
wiley   +1 more source

Mitragynine did not alter the L-type calcium current in hiPSC-CMs.

, 2014
(A) Time-course in vehicle (left) and wash out of Mitragynine (right), n = 4. (B) Left: Representative ICa,L traces prior to and post application of Mitragynine (10 µM). Pulse protocol is shown in the inset.
Heming Wei (280453), Jianjun Wu (276191), Mohd Fadzly Amar Jamil (336866), Mohd Ilham Adenan (678492), Philip Wong (73144), Jun Lu (36049), Winston Shim (280454), Mei Lan Tan (678491)   +7 more
core   +1 more source

Commentary on Comstock et al.: Here we go again—Kratom and the failure to learn from the opioid crisis

Addiction, Volume 121, Issue 9, Page 2468-2469, September 2026.
Andrew Kolodny
wiley   +1 more source

Effects of morphine treatment, morphine withdrawal and mitragynine on swimming behavior in adult zebrafish using the novel tank diving test.

, 2013
(A). Effect of two weeks chronic morphine treatment (1.5 mg/L), 24 h morphine withdrawal and morphine withdrawal in presence of 2 mg/L mitragynine on swimming behavior of zebrafish.
Mohd Fadzly Amar Jamil (336866), Alexander Chong Shu-Chien (223934), Mohamad Ilham Adenan (336867), Beng-Siang Khor (336865)   +3 more
core   +1 more source

The Effects Of Mitragynine On P-Glycoprotein Regulations And Its Neurotoxicity Mechanisms In Brain Cell Lines [PDF]

, 2021
The main objective is to determine the effects of mitragynine on P-gp regulations and neurotoxicity effects of drug-herb interactions between mitragynine and P-gp substrates in the PC12 cells using both in silico and in vitro ...
Abduraman, Muhammad Asyraf
core   +1 more source