Results 71 to 80 of about 2,217 (207)

Novel psychoactive substances of interest for psychiatry [PDF]

, 2015
Novel psychoactive substances include synthetic cannabinoids, cathinone derivatives, psychedelic phenethylamines, novel stimulants, synthetic opioids, tryptamine derivatives, phencyclidine-like dissociatives, piperazines, GABA-A/B receptor agonists, a ...
Corkery, John, Orsolini, Laura, Papanti, Duccio, Schifano, Fabrizio   +3 more
core   +1 more source

Nature's first “atypical opioids”: Kratom and mitragynines [PDF]

Journal of Clinical Pharmacy and Therapeutics, 2018
Advances in pain research have led to an understanding that many pains are driven by more than one underlying (patho)physiologic cause (ie, they are "multimechanistic") and that better pain relief is obtained with fewer adverse effects when an analgesic is correspondingly multimechanistic.
R. B. Raffa, J. V. Pergolizzi, R. Taylor, M. H. Ossipov   +3 more
openaire   +2 more sources

Copper‐Catalyzed Synthesis of C‐2 Substituted Indolin‐3‐Ones and Indolin‐3‐One [4+2] Cycloadducts Through Azide‐Tethered Iodonium Ylides

Asian Journal of Organic Chemistry, Volume 14, Issue 5, May 2025.
Azide‐tethered iodonium ylides under copper catalysis generate metallocarbenes that undergo intramolecular trapping by the azide moiety and generate a reactive C‐acylimine, effectively coupling two nucleophilic centers. This intermediate can be trapped by a wide range of nucleophiles or 1,3‐dienes producing complex indolin‐3‐ones and ...
Israel Najar Guerrero, Zinah Al‐Khateeb, F. G. West   +2 more
wiley   +1 more source

Biased Opioid Ligands

Molecules, 2020
Achieving effective pain management is one of the major challenges associated with modern day medicine. Opioids, such as morphine, have been the reference treatment for moderate to severe acute pain not excluding chronic pain modalities.
Abdelfattah Faouzi, Balazs R. Varga, Susruta Majumdar   +2 more
doaj   +1 more source

Accelerated Solvent Extractions (ASE) of Mitragyna speciosa Korth. (Kratom) Leaves: Evaluation of Its Cytotoxicity and Antinociceptive Activity

Molecules, 2021
Mitragyna speciosa Korth (kratom) is known for its psychoactive and analgesic properties. Mitragynine is the primary constituent present in kratom leaves.
Yong Sean Goh, Thiruventhan Karunakaran, Vikneswaran Murugaiyah, Rameshkumar Santhanam, Mohamad Hafizi Abu Bakar, Surash Ramanathan   +5 more
doaj   +1 more source

"Spice", "Kryptonite", "Black Mamba": An overview of brand names and marketing stragtegies of Novel Psychoactive Substances on the Web [PDF]

, 2014
Novel Psychoactive Substances (NPSs) are often sold online as “legal” and “safer” alternatives to International Controlled Drugs (ICDs) with captivating marketing strategies.
Advisory Council on the Misuse of Drugs (ACMD), Bersani F.S., Bigdeli I., Bruno R., Corazza O., Corazza O., Drug Enforcement Administration, Department of Justice, Evans-Brown M., Lesiak A.D., Musshoff F., United Nations Office on Drugs and Crime (UNODC)   +10 more
core   +2 more sources

A Drug Toxicity Death Involving Propylhexedrine and Mitragynine* [PDF]

Journal of Analytical Toxicology, 2011
A death involving abuse of propylhexedrine and mitragynine is reported. Propylhexedrine is a potent α-adrenergic sympathomimetic amine found in nasal decongestant inhalers. The decedent was found dead in his living quarters with no signs of physical trauma.
Justin M, Holler, Shawn P, Vorce, Pamela C, McDonough-Bender, Joseph, Magluilo, Carol J, Solomon, Barry, Levine   +5 more
openaire   +2 more sources

Epidemiology of New Psychoactive Substances in Relation to Traditional Drugs of Abuse in Clinical Oral Fluid Samples

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 2, February 2025.
ABSTRACT New psychoactive substances (NPS) are health‐hazardous through unpredictable toxicity and effects and largely unknown epidemiology, motivating studies of the latter. Up to 138 NPS were retrospectively identified using liquid chromatography‐high resolution mass spectrometry data from all 34 183 oral fluid drug samples collected in one Swedish ...
Magnus A. B. Axelsson, Hanna Lövgren, Robert Kronstrand, Henrik Green, Moa Andresen Bergström   +4 more
wiley   +1 more source

Development and validation of a quantitative method for the analysis of delta‐9‐tetrahydrocannabinol (delta‐9‐THC), delta‐8‐tetrahydrocannabinol (delta‐8‐THC), delta‐9‐tetrahydrocannabinolic acid (THCA), and cannabidiol (CBD) in botanicals, edibles, liquids, oils, waxes, and bath products by gas chromatography mass spectrometry (GC/MS)

Journal of Forensic Sciences, Volume 69, Issue 5, Page 1718-1729, September 2024.
Abstract A quantitative gas chromatography mass spectrometry (GC/MS) method was developed for delta‐9‐tetrahydrocannabinol (delta‐9‐THC), delta‐8‐tetrahydrocannabinol (delta‐8‐THC), tetrahydrocannabinolic acid (THCA), and cannabidiol (CBD) in matrices including plant material, liquids and oils, waxes, edibles, and bath and body products.
Sarah A. Shuda, Joshua F. Folger, Erin Spargo, Barry K. Logan   +3 more
wiley   +1 more source

Studies on the phase I and II metabolism and the toxicological analysis of the alkaloids of the herbal drug of abuse Mitragyna speciosa Korth. (Kratom) using gas chromatography-mass spectrometry and liquid chromatography coupled to low- and high-resolution linear ion trap mass spectrometry [PDF]

, 2011
In the presented studies, the herbal drug Kratom (Mitragyna speciosa) was investigated regarding its metabolism and its toxicological analysis in rat and human urine.
Philipp, Anika-Anina
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