Results 61 to 70 of about 2,217 (207)

Mitragynine Attenuates Morphine Withdrawal Effects in Rats—A Comparison With Methadone and Buprenorphine

Frontiers in Psychiatry, 2020
BackgroundOpiate addiction is a major health problem in many countries. A crucial component of the medical treatment is the management of highly aversive opiate withdrawal signs, which may otherwise lead to resumption of drug taking.
Rahimah Hassan, Cheah Pike See, Sasidharan Sreenivasan, Sharif M. Mansor, Christian P. Müller, Zurina Hassan, Zurina Hassan   +6 more
doaj   +1 more source

Case Report: Treatment of Kratom Use Disorder With a Classical Tricyclic Antidepressant

Frontiers in Psychiatry, 2021
Kratom or Mitragyna speciosa (Korth.) is an evergreen tree of the coffee family native to South-East Asia and Australasia. It is used by locals recreationally to induce stimulant and sedative effects and medically to soothe pain and opiate withdrawal ...
Alessandro E. Vento, Alessandro E. Vento, Simone de Persis, Sergio De Filippis, Fabrizio Schifano, Flavia Napoletano, John M. Corkery, Georgios D. Kotzalidis, Georgios D. Kotzalidis   +8 more
doaj   +1 more source

Determination of Psychoactive Mitragynine Drug in Suspected Kratom Species Collected from Various Geographical Areas in the Philippines: A Pilot Study on Existing Local Plant-based New Psychoactive Su

Arab Journal of Forensic Sciences & Forensic Medicine, 2019
Kratom is a tropical tree indigenous to South East Asian countries and has been traditionally used by natives to increase work efficiency and treat selected illnesses.
Atty. Severino P. Uy, Shaila Jr, S. Seville, Jasmyne L. M. Jaranilla, Yvette K. S. Desamito, Reynalyn P. Barbacena, Ronald J. A. Narceda   +5 more
doaj   +1 more source

Sedative, cognitive impairment and anxiolytic effects of acute Mitragyna speciosa in rodents [PDF]

, 2013
Mitragyna speciosa, a plant from Rubiaceae family, was reported to have an opium-like effect and their coca-like stimulative ability to combat fatigue and enhance tolerance to hard work.
Adzhar, Muhammad Farhan, Amom, Zulkhairi, Baharuldin, Mohamad Taufik Hidayat, Fakurazi, Sharida, Mat Taib, Che Norma, Md Akim, Abdah, Md Rasul, Mohd Saifuddin, Mohd Moklas, Mohamad Aris, Muhamamd Yusof, Muhammad Khairulasraf, Suliman, Noor Azuin, Zakaria, Fatin Nadzirah   +10 more
core   +1 more source

Metal‐Catalyzed C(sp2)–H Bond Functionalization of Indolinone‐ and Indanone‐Type Chemical Platforms En Route Toward Late‐Stage Functionalization

Advanced Synthesis &Catalysis, Volume 368, Issue 8, 15 April 2026.
An in‐depth survey dealing with the aromatic C—H bond functionalization of biologically‐relevant scaffolds featuring the indolinone and indanone core is discussed as they are unique aromatic scaffolds that are 1,2‐doubly fused with small five‐membered rings.
Vanessa Delahaye, Sylvie Dérien, Mathieu Achard, Rafael Gramage‐Doria   +3 more
wiley   +1 more source

Identification of “Kratom” (Mitragyna speciosa) Alkaloids in Commercially Available Products [PDF]

, 2017
“Kratom” is the common name for the botanical mitragyna speciosa. It is a tree native to Southeast Asia in which leaves contain the psychoactive alkaloids mitragynine and 7-hydroxymitragynine. Kratom is often ingested as teas, chewed, or smoked.
Grzymkowski, Julia, Peace, Michelle R, Poklis, Justin   +2 more
core   +1 more source

User Experiences of Development of Dependence on the Synthetic Cannabinoids, 5f-AKB48 and 5F-PB-22, and Subsequent Withdrawal Syndromes [PDF]

, 2017
Emergence of synthetic cannabinoids (SCBs) in herbal smoking mixtures is a public health concern. New SCB’s such as 5f-AKB48 and 5F-PB-22 have been detected in French seizures and in sudden death post mortems in the US.
A Grigoryev, A Grigoryev, A Helander, A Kjellgren, A Rominger, AB Schneir, AJ Budney, AR Winstock, C Coffey, C Soussan, CK Tung, CL Arfken, CM Caviness, CS Berry-Caban, D Castellanos, D Hurst, D Vearrier, D Zuba, E Husserl, Evelyn Hearne, EW Gunderson, EW Gunderson, F Schifano, F Schifano, F Schifano, F Westphal, G Behonick, G Karlsson, H Müller, H Müller, I Vardakou, J Hillebrand, J Simmons, JJ Levasseur, JM Pierre, JR Cornelius, JR Simmons, K McElrath, KA Seely, KA Seely, KL Egan, L Ernst, L Fattore, LD Johnston, LK Brents, LK Brents, LK Brents, M Gossop, M Hermanns-Clausen, M Spaderna, M Wallendorf, Marie Claire Van Hout, MB Forrester, MC Hout Van, MC Hout Van, MC Hout Van, MC Hout Van, MC Hout Van, MH Baumann, MJ Barratt, ML Copersino, N Uchiyama, N Veer Van der, NA Gillespie, O Roussel, P Deluca, P Griffiths, PI Dargan, R Kikura-Hanajiri, R Lindigkeit, R Vandrey, S Dresen, S Every-Palmer, S Every-Palmer, S Hudson, SJ Bright, SS Tuv, T Chung, T Sobolevsky, US Zimmermann, V Auwärter, VS Bebarta, WE Fantegrossi, YS Lincoln   +83 more
core   +1 more source

Enhancement of Endothelial Barrier Permeability by Mitragynine

Biological & Pharmaceutical Bulletin, 2017
Persistent inhalation of mitragynine (MG), a major alkaloid in the leaves of Mitragyna speciosa, causes various systemic adverse effects such as seizure, diarrhea and arthralgias, but its toxicity to endothelial cells and effects on barrier function of the cells are poorly understood.
Toshiyuki, Matsunaga, Yoshifumi, Morikawa, Kyoko, Kamase, Misato, Horinouchi, Yasuhide, Sasajima, Koichi, Suenami, Kiyohito, Sato, Yuji, Takekoshi, Satoshi, Endo, Ossama, El-Kabbani, Akira, Ikari   +10 more
openaire   +3 more sources

Kratom (Mitragynine) Ingestion Requiring Naloxone Reversal [PDF]

Clinical Practice and Cases in Emergency Medicine, 2019
Kratom (mitragynine) is a naturally occurring opioid agonist whose use has been escalating. Its suppliers advertise it as a safe alternative for opioids and a safe treatment for opioid-withdrawal symptoms. There has been controversy in the past two years regarding the legal status and lack of regulation surrounding kratom.
Overbeek, Daniel L., Abraham, Jonathan, Munzer, Brendan W.   +2 more
openaire   +5 more sources

The 730 nm Picosecond Titanium Sapphire Laser for Treatment of Kratom‐Induced Hyperpigmentation

Lasers in Surgery and Medicine, Volume 57, Issue 5, Page 373-382, July 2025.
ABSTRACT Objectives This case series reports the use of the 730‐nm picosecond titanium‐sapphire laser in the treatment of kratom‐induced hyperpigmentation, a dermatological side effect associated with the use of Mitragyna speciosa, which remains poorly understood. Methods A series of patients with kratom‐induced hyperpigmentation were treated using the
Alanoud A. Alhadyani, Christen Samaan, Girish S. Munavalli   +2 more
wiley   +1 more source