Results 61 to 70 of about 1,701 (157)

Epidemiology of New Psychoactive Substances in Relation to Traditional Drugs of Abuse in Clinical Oral Fluid Samples

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 2, February 2025.
ABSTRACT New psychoactive substances (NPS) are health‐hazardous through unpredictable toxicity and effects and largely unknown epidemiology, motivating studies of the latter. Up to 138 NPS were retrospectively identified using liquid chromatography‐high resolution mass spectrometry data from all 34 183 oral fluid drug samples collected in one Swedish ...
Magnus A. B. Axelsson, Hanna Lövgren, Robert Kronstrand, Henrik Green, Moa Andresen Bergström   +4 more
wiley   +1 more source

Inhibitory effect of mitragynine and quercetin against ACC1-medated Accetyl-CoA.

, 2023
Inhibitory effect of mitragynine and quercetin against ACC1-medated Accetyl-CoA.
Phisit Pouyfung (4358473), Atikarn Janthongkaw (17020498), Supaporn Yimthiang (17020507), Tanaporn Khampaya (17020504), Ruixue Ma (9321857), Sirinthip Klaophimai (17020501), Apirak Bumyut (17020510), Yilin Yang (294361)   +7 more
core   +1 more source

Screening, docking, and molecular dynamics analysis of Mitragyna speciosa (Korth.) compounds for targeting HER2 in breast cancer

Current Research in Structural Biology
Breast cancer remains the most commonly diagnosed cancer among women worldwide, with approximately 2.3 million new cases reported in 2022. In the United States alone, an estimated 310,720 new cases of female breast cancer are expected in 2024.
Nabila Hadiah Akbar, Farendina Suarantika, Taufik Muhammad Fakih, Ariranur Haniffadli, Khoirunnisa Muslimawati, Aditya Maulana Perdana Putra   +5 more
doaj   +1 more source

Development and validation of a quantitative method for the analysis of delta‐9‐tetrahydrocannabinol (delta‐9‐THC), delta‐8‐tetrahydrocannabinol (delta‐8‐THC), delta‐9‐tetrahydrocannabinolic acid (THCA), and cannabidiol (CBD) in botanicals, edibles, liquids, oils, waxes, and bath products by gas chromatography mass spectrometry (GC/MS)

Journal of Forensic Sciences, Volume 69, Issue 5, Page 1718-1729, September 2024.
Abstract A quantitative gas chromatography mass spectrometry (GC/MS) method was developed for delta‐9‐tetrahydrocannabinol (delta‐9‐THC), delta‐8‐tetrahydrocannabinol (delta‐8‐THC), tetrahydrocannabinolic acid (THCA), and cannabidiol (CBD) in matrices including plant material, liquids and oils, waxes, edibles, and bath and body products.
Sarah A. Shuda, Joshua F. Folger, Erin Spargo, Barry K. Logan   +3 more
wiley   +1 more source

Antinociceptive Action of Mitragynine and its Synthetic Analogs in Mice [PDF]

, 2008
Mitragynine is a major alkaloid extracted from the leaves of the Thai traditional herb, Mitrcigymi speciosa Korth (Rubiaceae). The extracts of this plant have been used as substitutes for opium and recent studies have reported that mitragynine possesses ...
Franklin, La Donna Evette
core   +1 more source

Prediction of physicochemical and pharmacokinetic properties of botanical constituents by computational models

Journal of Applied Toxicology, Volume 44, Issue 8, Page 1236-1245, August 2024.
Abstract Botanicals contain complex mixtures of chemicals most of which lack pharmacokinetic data in humans. Since physicochemical and pharmacokinetic properties dictate the in vivo exposure of botanical constituents, these parameters greatly impact the pharmacological and toxicological effects of botanicals in consumer products.
Yitong Liu, Michael Lawless, Miao Li, Kiara Fairman, Michelle R. Embry, Constance A. Mitchell   +5 more
wiley   +1 more source

Effects of cytochrome P450 (CYP) 2D6 inhibitions in in vivo toxicity studies of mitragynine [PDF]

, 2017
Mitragynine, the most abundant active component found in the leaves of Mitragyna speciosa, has been proposed to use as pain and opiate withdrawal symptoms reliever.
Chik, Z.
core   +1 more source

Broad evidence of xylazine in the UK illicit drug market beyond heroin supplies: Triangulating from toxicology, drug‐testing and law enforcement

Addiction, Volume 119, Issue 7, Page 1301-1309, July 2024.
Abstract Background and aims Xylazine is a non‐opioid sedative which has spread rapidly throughout the US illicit drug supply. This study aimed to describe the spread of xylazine throughout the UK illicit drug supply. Methods Xylazine detections in human biological samples were collated from toxicology laboratories operating in the United Kingdom with ...
Caroline S. Copeland, Kathleen Rice, Kirsten L. Rock, Simon Hudson, Peter Streete, Alexander J. Lawson, Lewis Couchman, Adam Holland, Stephen Morley   +8 more
wiley   +1 more source

Trends and challenges in the use of drugs as forensic evidence: A scientometric approach to map the current literature

WIREs Forensic Science, Volume 6, Issue 2, March/April 2024.
Common keywords listed in the references cited in the INTERPOL IFSMS reports (1991–2022). Abstract The rapid increase in the production and distribution of illicit drugs has led to vast amounts of data being generated through research and other publications, making it difficult to effectively distill and analyze current and emerging trends. The present
Caitlyn Norman, Dorothy Xi Yue Lim, Taylor Henderson, Fabio Casali, Niamh Nic Daéid, Lorna Nisbet, Hervé Ménard   +6 more
wiley   +1 more source

Pharmacokinetics of mitragynine in man

, 2015
Satariya Trakulsrichai,1,2 Korbtham Sathirakul,3,4 Saranya Auparakkitanon,5 Jatupon Krongvorakul,5 Jetjamnong Sueajai,5 Nantida Noumjad,5 Chonlaphat Sukasem,5 Winai Wananukul2,6 1Department of Emergency Medicine, Faculty of Medicine Ramathibodi Hospital,
Sathirakul K, Wananukul W, Sueajai J, Sukasem C, Trakulsrichai S, Noumjad N, Auparakkitanon S, Krongvorakul J   +7 more
core