Results 81 to 90 of about 1,701 (157)

An In Vitro Examination of Whether Kratom Extracts Enhance the Cytotoxicity of Low-Dose Doxorubicin against A549 Human Lung Cancer Cells

Molecules
Doxorubicin is an effective chemotherapeutic agent in the treatment of solid hematological and non-hematological carcinoma. However, its long-term usage could result in side effects, such as cardiomyopathy, chronic heart failure, neurotoxicity and cancer
Asep Bayu, Siti Irma Rahmawati, Firmansyah Karim, Jonathan Ardhianto Panggabean, Dasilva Primarindu Nuswantari, Dwi Wahyu Indriani, Peni Ahmadi, Rendi Witular, Ni Luh Putu Indi Dharmayanti, Masteria Yunovilsa Putra   +9 more
doaj   +1 more source

Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression. [PDF]

, 2011
Mitragyna speciosa Korth. leaves have been used for decades as a traditional medicine to treat diarrhea, diabetes and to improve blood circulation by natives of Malaysia, Thailand and other regions of Southeast Asia.
Abdul Rahman, Shamima, Nasir, Farah Idayu, Adib Ridzuan, Nurul Raudzah, Baharuldin, Mohamad Taufik Hidayat, Fakurazi, Sharida, Mohd Moklas, Mohamad Aris, Apryani, Evhy   +6 more
core  

New psychoactive substances in roadway crash victims in California

Frontiers in Toxicology
BackgroundMotor vehicle crashes (MVCs) are a major global health concern. While alcohol continues to be a significant contributor to MVCs, the role of illicit and prescription drugs has increased in the last 4 decades.
Roy Gerona, Daniel Tomer, Donovan Nielsen, Allyson C. Sage, Deborah French, Juliana Tolles, James Alan Chenoweth   +6 more
doaj   +1 more source

ผลของการอบแห้งด้วยลมร้อนต่อการเปลี่ยนแปลงสีและปริมาณสารไมทราไจนีน ของใบกระท่อม | Effect of Hot Air Drying on Color Changes and Mitragynine Content of Kratom Leaves [PDF]

, 2023
            Kratom is an herbal leaf from a tree of the Rubiaceae family. The main component of the leaves is mitragynine, which is an alkaloid exhibiting both stimulant and opioid-like effects.
ชั่งสิริพร, จันทิมา, พงศ์ยี่หล้า, พฤกระยา, ชัยฤกษ์, นิรณา   +2 more
core  

Kratom safety and toxicology in the public health context: research needs to better inform regulation

Frontiers in Pharmacology
Although kratom use has been part of life for centuries in Southeast Asia, the availability and use of kratom in the United States (US) increased substantially since the early 2000s when there was little information on kratom pharmacology, use patterns ...
Jack E. Henningfield, Jack E. Henningfield, Oliver Grundmann, Marilyn A. Huestis, Kirsten E. Smith   +4 more
doaj   +1 more source

Evaluation of pharmacokinetics and blood-brain barrier permeability of mitragynine using in vivo microdialysis technique

, 2017
A microdialysis system coupled with a sensitive ultra-fast liquid chromatography–mass spectrometry (UFLC-MS) method was developed for the pharmacokinetic analysis of mitragynine in rat blood and striatum.
Chik, Z., Alshawsh, M.A., Kong, W.M., Mohamed, Z.   +3 more
core   +1 more source

Alkaloid biosynthesis in medicinal crop kratom (Mitragyna speciosa) varies with postharvest, genetic, and seasonal factors

Frontiers in Plant Science
IntroductionKratom (Mitragyna speciosa), a medicinally valuable ethnobotanical tree native to Southeast Asia, has traditionally been used to combat fatigue and enhance productivity.
Mengzi Zhang, Annabella Lyndon, Siva Rama Raju Kanumuri, Abhisheak Sharma, Abhisheak Sharma, Brian J. Pearson, Brian J. Pearson, Christopher R. McCurdy, Christopher R. McCurdy, Jianjun Chen   +9 more
doaj   +1 more source

The role of mesolimbic system and lateral habenular molecular targets (CB₁, GluA₁ and NK₁ receptors) in mitragyna speciosa korth (ketum) addiction in the mitragynine-sensitised swiss albino mice [PDF]

, 2021
There is a growing trend to use the leaves of Malaysian folklore medicinal plant Mitragyna speciosa Korth. (or ketum) for recreational high and as a self-medication alternative to traditional opiates, hence subjecting it to addictive liabilities ...
Ismail, Nurul Iman Wan
core  

Formulation and Delivery of Mitragynine: A Mini Review [PDF]

Mitragynine is the most abundant psychoactive indole alkaloid found in the leaves of Mitragyna speciosa, which is commonly known as “Kratom”, and is distributed widely in Indonesia, Malaysia, Papua New Guinea, the Philippines, and Thailand. The leaves of
Sarker, S, Nahar, L
core   +1 more source

Extraction and detection of mitragynine in Kratom leaves by high-performance liquid chromatography

Mitragyna speciosa, also known as Kratom, is an evergreen tree native to Southeast Asia that has been used in traditional medicine to relieve pain.
Taehoon Ha (9954019), Karno Ng (18263786)   +1 more
core   +1 more source