Results 81 to 90 of about 2,217 (207)

Prediction of physicochemical and pharmacokinetic properties of botanical constituents by computational models

Journal of Applied Toxicology, Volume 44, Issue 8, Page 1236-1245, August 2024.
Abstract Botanicals contain complex mixtures of chemicals most of which lack pharmacokinetic data in humans. Since physicochemical and pharmacokinetic properties dictate the in vivo exposure of botanical constituents, these parameters greatly impact the pharmacological and toxicological effects of botanicals in consumer products.
Yitong Liu, Michael Lawless, Miao Li, Kiara Fairman, Michelle R. Embry, Constance A. Mitchell   +5 more
wiley   +1 more source

Profile, effects, and toxicity of novel psychoactive substances: A systematic review of quantitative studies [PDF]

, 2017
OBJECTIVE: To investigate the profile, effects, and toxicity of novel psychoactive substances (NPS). METHODS: A systematic literature review was conducted between May 2015 and February 2016 and included 19 databases.
Antonowicz, Arora, Belton, Borek, Corazza, Corazza, Corazza, Corbo, Corkery, Dargan, Davey, Davies, Eiden, Gerace, Goggin, Gonzalez, Gray, Hohmann, Hondebrink, Karinen, Kelly, Kelly, Khaled, Kulhawik, Lajoie, Martinotti, Papaseit, Patterson, Rojek, Schmidt, Spiller, Stephenson, Stogner, Tracy, Winslow, Winstock   +35 more
core   +2 more sources

Broad evidence of xylazine in the UK illicit drug market beyond heroin supplies: Triangulating from toxicology, drug‐testing and law enforcement

Addiction, Volume 119, Issue 7, Page 1301-1309, July 2024.
Abstract Background and aims Xylazine is a non‐opioid sedative which has spread rapidly throughout the US illicit drug supply. This study aimed to describe the spread of xylazine throughout the UK illicit drug supply. Methods Xylazine detections in human biological samples were collated from toxicology laboratories operating in the United Kingdom with ...
Caroline S. Copeland, Kathleen Rice, Kirsten L. Rock, Simon Hudson, Peter Streete, Alexander J. Lawson, Lewis Couchman, Adam Holland, Stephen Morley   +8 more
wiley   +1 more source

Uji Efek Sedatif Fraksi Etanol Daun Kratom (Mitragyna Speciosa Korth.) Pada Mencit Jantan Galur Balb/c [PDF]

, 2013
Kratom (Mitragyna speciosa Korth.) is one of traditional medical plant that canproduces both stimulant effects (in low doses) and sedative effects (in high doses).
Ridayani, Y. (Yeni)
core   +1 more source

Trends and challenges in the use of drugs as forensic evidence: A scientometric approach to map the current literature

WIREs Forensic Science, Volume 6, Issue 2, March/April 2024.
Common keywords listed in the references cited in the INTERPOL IFSMS reports (1991–2022). Abstract The rapid increase in the production and distribution of illicit drugs has led to vast amounts of data being generated through research and other publications, making it difficult to effectively distill and analyze current and emerging trends. The present
Caitlyn Norman, Dorothy Xi Yue Lim, Taylor Henderson, Fabio Casali, Niamh Nic Daéid, Lorna Nisbet, Hervé Ménard   +6 more
wiley   +1 more source

A case of fatal overdose involving both hydromorphone and kratom

Journal of Forensic Sciences, Volume 69, Issue 1, Page 355-358, January 2024.
Abstract Kratom is a plant originating in Southeast Asia that has been used for its dose‐dependent stimulant and opioid effects. The main active compound in kratom is mitragynine, an alkaloid with affinity for the mu‐opioid receptor. Toxicity and fatalities related to kratom use have increased substantially in recent years.
Thomas Shi, Jennifer L. Shea
wiley   +1 more source

Effect of Kramecyne on the Inflammatory Response in Lipopolysaccharide-Stimulated Peritoneal Macrophages [PDF]

, 2013
Kramecyne is a new peroxide, it was isolated from Krameria cytisoides, methanol extract, and this plant was mostly found in North and South America. This compound showed potent anti-inflammatory activity; however, the mechanisms by which this compound ...
E. Sánchez-Miranda, J. Lemus-Bautista, J. Pérez-Ramos, S. Pérez   +3 more
core   +1 more source

Drug Vaping: From the Dangers of Misuse to New Therapeutic Devices. [PDF]

, 2016
Users of e-cigarettes are unwitting volunteers participating in a worldwide epidemiological study. Because of the obvious benefits of e-cigarettes compared with traditional cigarette smoking, these electronic devices have been introduced all around the ...
Varlet, V.
core   +2 more sources

Uji Efek Sedatif Ekstrak N-heksan Dari Daun Kratom (Mitragyna Speciosa Korth.) Pada Mencit Jantan Galur Balb/c [PDF]

, 2013
Insomnia is a sleep disorder that can cause a variety of serious health problemsrequiring treatment. The using of synthetic drugs have dangerous side effects than therapywhich is resulted. Therefore, alternative treatments which derived from natural such
Hidayati, A. (Anna)
core   +1 more source

Drogas legales emergentes: marihuana sintética, kratom, salvia divinorum, metoxetamina y los derivados de la piperazina [PDF]

, 2015
A pesar de su amplia oferta y disponibilidad a través de internet, muchas de las drogas de abuso emergentes siguen siendo desconocidas para un gran número de médicos y profesionales sanitarios.
Aliño, Marta, Espert Tortajada, Raúl, Gadea Domenech, Marien, Oltra Cucarella, Javier, Pérez San Miguel, Joana   +4 more
core