Results 91 to 100 of about 1,701 (157)

Mitragynine as an anthelmintic for caprine strongyles [PDF]

, 2012
Helminth infection is one of the most important causes of mortality and morbidity in small ruminant industries in Malaysia. Hence, helminth infection can lead to direct or indirect economic loss to farmers.
Abdul Aziz, Farah Hida, Abdul Kadir, Arifah, Abdullah Sani, Rehana   +2 more
core  

Higher accumulation of mitragynine in Mitragyna speciosa (kratom) leaves affected by insect attack.

PLoS ONE
Kratom leaves are widely consumed by locals to increase their stamina for working longer hours in the field. However, insect damage to the leaves can lead to significant loss of leaf harvest. Despite this, there remains considerable uncertainty regarding
Nisa Leksungnoen, Tushar Andriyas, Rossarin Tansawat, Pichaya Pongchaidacha, Piyawadi Khaoiam, Thanundorn Thanusuwannasak, Chatchai Ngernsaengsaruay, Chawatat Thanoosing, Suwimon Uthairatsamee   +8 more
doaj   +1 more source

A review on multi-therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine: Experimental evidence and future perspectives

Kuwait Journal of Science
Mitragyna speciosa (kratom) is a traditional medicinal plant of Southeast Asia, known for its pharmacologically active alkaloids, mitragynine and 7-hydroxymitragynine.
doaj   +1 more source

Kratom leaf extracts exert hypolipidaemic effects via the modulation of PCSK9 and LDLR pathways in HepG2 cells

Scientific Reports
Kratom (Mitragyna speciosa (Korth.) Havil.) has been reported to reduce serum lipids. However, the molecular mechanism underlying hypolipidaemic effect of kratom is still unclear.
Nantiya Nawaka, Monthon Lertcanawanichakul, Sureerut Porntadavity, Burabha Pussadhamma, Nutjaree Jeenduang   +4 more
doaj   +1 more source

Exploring the Therapeutic Potential of Mitragynine and Corynoxeine: Kratom-Derived Indole and Oxindole Alkaloids for Pain Management

Pharmaceuticals
The search for effective pain management solutions remains a critical challenge, especially amidst growing concerns over the use of conventional opioids.
Ahmed S. Alford, Hope L. Moreno, Menny M. Benjamin, Cody F. Dickinson, Mark T. Hamann   +4 more
doaj   +1 more source

A Comparison of Mitragyna Speciosa and Mitragynine Against Opioids on Thermal Nociception in Rats [PDF]

, 2015
The purpose of this experiment is to compare Mitragyna speciosa (M. speciosa) and its active component, mitragynine, a known µ-opioid receptor (MOR) agonist, against well-known and commonly abused opioids, morphine and oxycodone.
Criddle, Catherine
core   +2 more sources

Dual anti-inflammatory activities of COX-2/5-LOX driven by kratom alkaloid extracts in lipopolysaccharide-induced RAW 264.7 cells

Scientific Reports
Cyclooxygenase (COX) and lipoxygenase (LOX) enzymes play a pivotal role in producing pro-inflammatory eicosanoids, including prostaglandins (PGs) and leukotrienes (LTs), in the inflammation process.
Siti Irma Rahmawati, Dwi Wahyu Indriani, Febby Nurdiya Ningsih, Mutia Hardhiyuna, Firdayani Firdayani, Peni Ahmadi, A’liyatur Rosyidah, Eris Septiana, Ni Luh Putu Indi Dharmayanti, Asep Bayu, Masteria Yunovilsa Putra   +10 more
doaj   +1 more source

Multifaceted modulation of human opioid receptors by kratom alkaloids: binding affinity, functional selectivity, and allosteric activity

Frontiers in Pharmacology
IntroductionKratom (Mitragyna speciosa) contains over 50 alkaloids, yet the pharmacological activity of most remains poorly defined, limiting our understanding of its therapeutic potential and safety profile.MethodsWe conducted a comprehensive evaluation
S. E. Hemby, M. Rangel-Grimaldo, S. McIntosh, J. Zheng, L. Flores-Bocanegra, T. N. Graf, R. A. Coover, N. H. Oberlies   +7 more
doaj   +1 more source

Cross-reinstatement Models Of Mitragynine-morphine Drugseeking Addictive Behaviour And Dopaminergic Involvement In Sprague-dawley Rats [PDF]

Kratom (Mitragyna speciosa Korth.) is a medicinal herb which gained fame for its potential as an opioid substitute. Nevertheless, little is known about the abuse potential of its major alkaloid, mitragynine, especially in relapse to drug abuse ...
Japarin, Rima Atria
core   +1 more source

A design of experiments approach to production of medicinal bioactives in <i>Mitragyna speciosa</i> (Korth.) Havil. [PDF]

Pharm Biol
Giebelhaus RT, Brown PN, Ali M, Dodds AM, Erland LAE.   +4 more
europepmc   +1 more source