Results 111 to 120 of about 2,217 (207)

Mitragynine and 7-Hydroxymitragynine: Bidirectional Effects on Breathing in Rats

The Journal of Pharmacology and Experimental Therapeutics
Abstract The use of kratom as an alternative to conventional opioids has surged, driven largely by anecdotal reports of its efficacy for pain relief and opioid withdrawal management. The growing prevalence of kratom products enriched with 7-hydroxymitragynine (7-HMG), an active metabolite of mitragynine (MG), necessitates evaluating the
Julio D. Zuarth Gonzalez, Alexandria K. Ragsdale, Sushobhan Mukhopadhyay, Christopher R. McCurdy, Lance R. McMahon, Samuel Obeng, Jenny L. Wilkerson   +6 more
openaire   +3 more sources

Kratom leaf extracts exert hypolipidaemic effects via the modulation of PCSK9 and LDLR pathways in HepG2 cells

Scientific Reports
Kratom (Mitragyna speciosa (Korth.) Havil.) has been reported to reduce serum lipids. However, the molecular mechanism underlying hypolipidaemic effect of kratom is still unclear.
Nantiya Nawaka, Monthon Lertcanawanichakul, Sureerut Porntadavity, Burabha Pussadhamma, Nutjaree Jeenduang   +4 more
doaj   +1 more source

A Study of the Kratom Alkaloids and Their Binding to the μ-Opioid Receptor [PDF]

, 2019
Kratom, a plant commonly found in southeast Asia, has traditionally been used for medicinal treatments. Recently, however, the popularity of the drug has significantly increased due to its euphoric effects, leading to it being used as an alternative to ...
Chamblee, Reba Elizabeth Ann
core   +1 more source

生物試験 [PDF]

, 1995
村上 孝寿, 東田 道久, 松本 欣三, 渡辺 裕司   +3 more
core   +9 more sources

Dual anti-inflammatory activities of COX-2/5-LOX driven by kratom alkaloid extracts in lipopolysaccharide-induced RAW 264.7 cells

Scientific Reports
Cyclooxygenase (COX) and lipoxygenase (LOX) enzymes play a pivotal role in producing pro-inflammatory eicosanoids, including prostaglandins (PGs) and leukotrienes (LTs), in the inflammation process.
Siti Irma Rahmawati, Dwi Wahyu Indriani, Febby Nurdiya Ningsih, Mutia Hardhiyuna, Firdayani Firdayani, Peni Ahmadi, A’liyatur Rosyidah, Eris Septiana, Ni Luh Putu Indi Dharmayanti, Asep Bayu, Masteria Yunovilsa Putra   +10 more
doaj   +1 more source

Formulation and Delivery of Mitragynine: A Mini Review

Journal of Medicinal Natural Products
Mitragynine is the most abundant psychoactive indole alkaloid found in the leaves of Mitragyna speciosa, which is commonly known as “Kratom”, and is distributed widely in Indonesia, Malaysia, Papua New Guinea, the Philippines, and Thailand. The leaves of M.
Lutfun Nahar, Satyajit D. Sarker
openaire   +1 more source

Mitragynin [PDF]

, 2019
openaire   +1 more source

Technical report on N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]oxolane-2-carboxamide (tetrahydrofuranylfentanyl; THF-F). Annex 1 to the Risk Assessment Report on N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]oxolane-2- carboxamide (tetrahydrofuranylfentanyl). [PDF]

In accordance with Article 6 of Council Decision 2005/387/JHA on the information exchange, risk assessment and control of new psychoactive ...
Almeida, A, Brandt, SD, Christie, R, Elliott, S, Evans-Brown, M, Gallegos, A, Jorge, R, Sedefov, R, Sola, S, Valur Danielsson, H   +9 more
core  

Comparative Analysis of Mitragynine Content in Kratom Leaves (Mitragyna speciosa Korth) from Kabupaten Kapuas Hulu Using HPLC Method [PDF]

Opioid drugs are common analgesics for managing chronic pain, but they have significant short- and long-term side effects. Despite this, opioid consumption continues to rise in high-income countries, raising concerns about dependency.
Andriani, Astuti, Puji, Novianry, Virhan
core   +1 more source

Mitragynine and Morphine Stabilize Different Conformations of the μ‑Opioid Receptor as Revealed by Molecular Dynamics Simulation Studies. [PDF]

ACS Omega
Neupane NP, Mathews JT, Lingaraju S, You Y, Mathukumalli K, Das J.   +5 more
europepmc   +1 more source