Results 41 to 50 of about 2,738 (175)

Novel Psychoactive Substances 14Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs [PDF]

open access: yes, 2017
A feature of human culture is that we can learn to consume chemical compounds, derived from natural plants or synthetic fabrication, for their psychoactive effects.
Boris B. , Quednow   +8 more
core   +1 more source

Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression. [PDF]

open access: yes, 2011
Mitragyna speciosa Korth. leaves have been used for decades as a traditional medicine to treat diarrhea, diabetes and to improve blood circulation by natives of Malaysia, Thailand and other regions of Southeast Asia.
Abdul Rahman, Shamima   +6 more
core   +1 more source

Induction and Analysis of the Alkaloid Mitragynine Content of a Mitragyna speciosa Suspension Culture System upon Elicitation and Precursor Feeding

open access: yesThe Scientific World Journal, 2013
This study aimed to determine the effects of different concentrations and combinations of the phytohormones 2,4-dichlorophenoxy acetic acid (2,4-D), kinetin, 6-benzylaminopurine (BAP), and 1-naphthaleneacetic acid (NAA) on callus induction ...
Nor Nahazima Mohamad Zuldin   +5 more
doaj   +1 more source

Antinociceptive Activity of Aqueous Fraction of Kratom Leaves Mitragyna speciosa Korth.) on Male Swiss Albino Mice

open access: yesMajalah Obat Tradisional, 2018
Kratom (Mitragyna speciosa Korth.) has been known to have an analgesic opioid effect (antinociceptive). The major compound of kratom leaf is mitraginin, which has strong affinity on opioid receptor.
Widia Indri Nugraha   +2 more
doaj   +1 more source

High serum high-density lipoprotein and low serum triglycerides in Kratom users: A study of Kratom users in Thailand

open access: yesHeliyon, 2021
Objective: The present study aims to examine the association between Kratom use and serum lipid level. Method: This study compared the serum lipid profile of Kratom users and non-users living in Nam Phu Subdistrict, a special area that allows the ...
Aroon La-up   +2 more
doaj   +1 more source

Can Kratom (Mitragyna speciosa) Alleviate COVID-19 Pain? A Case Study

open access: yesFrontiers in Psychiatry, 2020
Among the symptoms of COVID-19 fever, general malaise, pain and aches, myalgia, fatigue, and headache can affect the quality of life of patients, even after the end of the acute phase of the infection and can be long lasting.
Antonio Metastasio   +9 more
doaj   +1 more source

Identification of “Kratom” (Mitragyna speciosa) Alkaloids in Commercially Available Products [PDF]

open access: yes, 2017
“Kratom” is the common name for the botanical mitragyna speciosa. It is a tree native to Southeast Asia in which leaves contain the psychoactive alkaloids mitragynine and 7-hydroxymitragynine. Kratom is often ingested as teas, chewed, or smoked.
Grzymkowski, Julia   +2 more
core   +1 more source

Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit beta-Arrestin-2. [PDF]

open access: yes, 2016
Natural products found in Mitragyna speciosa, commonly known as kratom, represent diverse scaffolds (indole, indolenine, and spiro pseudoindoxyl) with opioid activity, providing opportunities to better understand opioid pharmacology.
Borics, Attila   +5 more
core   +1 more source

Novel Histopathologic Features of Diffuse Blue‐Gray Hyperpigmentation Associated With Kratom Use: A Case Report and Literature Review

open access: yesJournal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Drug‐induced hyperpigmentation accounts for 10%–20% of acquired pigmentary disorders and can be misdiagnosed for other causes such as melasma, post inflammatory changes, or heavy metal deposition. Kratom (Mitragyna speciosa), a Southeast Asian plant with an opioid‐like profile, has been increasingly used in the United States for ...
Rita Kamoua   +4 more
wiley   +1 more source

The Combination of Mitragynine and Morphine Prevents the Development of Morphine Tolerance in Mice

open access: yesMolecules, 2013
Mitragynine (MG) is the major active alkaloid found in Mitragyna speciosa Korth. In the present study, we investigated the enhancement of analgesic action of MG when combined with morphine and the effect of the combination on the development of tolerance
Sharida Fakurazi   +5 more
doaj   +1 more source

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