Results 51 to 60 of about 9,834 (169)

Anti-inflammatory effects and potential mechanisms of Mitragyna speciosa methanol extract on λ-karagenan-induced inflammation model [PDF]

, 2022
Introduction: Mitragyna speciosa is known to have beneficial effects, such as antinociceptive and anti-inflammatory effects. There are some components that involve in inflammatory, such as Inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2 ...
Salim, Hotimah Masdan, Choirotussanijjah, Choirotussanijjah, Awwalia, Evi Sylvia, Alam, Ilham Putra   +3 more
core   +1 more source

A cell‐type‐specific regulon controlling monoterpene indole alkaloid biosynthesis with feedback and feedforward activation loops

New Phytologist, Volume 249, Issue 2, Page 945-960, January 2026.
Summary Monoterpene indole alkaloids (MIA) are a diverse class of plant natural products produced by a subset of lineages within the Asterid clade of eudicots. The diversity of MIAs provides a unique opportunity to study not only the evolution of biosynthetic genes but also their regulation.
Chenxin Li, Joshua C. Wood, Brieanne Vaillancourt, John P. Hamilton, Sophia L. Jones, Van‐Hung Bui, Thu‐Thuy T. Dang, C. Robin Buell   +7 more
wiley   +1 more source

Evaluation of mitragyna speciosa analgesic activity in mice / Salina Mohd Saad [PDF]

, 2006
The leaves of mitragyna spectosa (Rubiaceae) have been traditionally used as substitute for opium. Mitragynine is a major alkaloid constituent that is known to produce opioid like action when smoked, chewed or drunk.
Mohd Saad, Salina
core  

Transient Sensorineural Hearing Loss and Rhabdomyolysis, Associated With Chronic Kratom Use

Case Reports in Otolaryngology, Volume 2026, Issue 1, 2026.
Kratom is a colloquial name for products derived from the mitragyna plant species originating in Southeast Asia and now widely available in the United States as a dietary supplement. Kratom is used primarily for self‐management of pain, anxiety, and opioid withdrawal due to its partial agonist activity on mu opioid receptors, as well as other ...
Hiroto Watanabe, Kathy Zhang, Yekaterina Shapiro, Anuja Salgaonkar   +3 more
wiley   +1 more source

Behavioural Pharmacology Of Mitragyna speciosa Korth Standardized Methanol Extract In An Animal Model [PDF]

, 2011
Mitragyna speciosa Korth is one of the species of plant used by locals especially in Thailand and Malaysia in treating diarrhea, worm infestations and acts as an analgesic and antipyretic.
Senik @ Nawi, Mohd Harizal
core   +1 more source

POTENSI AKTIVITAS ANTIOKSIDAN DAN PENETAPAN KADAR FENOLIK TOTAL EKSTRAK DAUN KRATOM (Mitragyna speciosa Korth.) MENGGUNAKAN VARIASI PELARUT

JIIS: Jurnal Ilmiah Ibnu Sina
Kratom (Mitragyna speciosa) merupakan tanaman herbal khas Asia Tenggara yang memiliki kandungan metabolit sekunder. Karakteristik ekstrak tanaman obat sangat dipengaruhi oleh jenis pelarut yang digunakan selama proses ekstraksi, khususnya terhadap ...
Akhmad Riski, Nanang Fakhrudin, Agung Endro Nugroho, Rakhmadhan Niah, Lalu Husnul Hidayat   +4 more
doaj   +1 more source

High serum high-density lipoprotein and low serum triglycerides in Kratom users: A study of Kratom users in Thailand

Heliyon, 2021
Objective: The present study aims to examine the association between Kratom use and serum lipid level. Method: This study compared the serum lipid profile of Kratom users and non-users living in Nam Phu Subdistrict, a special area that allows the ...
Aroon La-up, Udomsak Saengow, Apinun Aramrattana   +2 more
doaj   +1 more source

The Combination of Mitragynine and Morphine Prevents the Development of Morphine Tolerance in Mice

Molecules, 2013
Mitragynine (MG) is the major active alkaloid found in Mitragyna speciosa Korth. In the present study, we investigated the enhancement of analgesic action of MG when combined with morphine and the effect of the combination on the development of tolerance
Sharida Fakurazi, Shamima Abdul Rahman, Mohamad Taufik Hidayat, Hairuszah Ithnin, Mohamad Aris Mohd Moklas, Palanisamy Arulselvan   +5 more
doaj   +1 more source

The 730 nm Picosecond Titanium Sapphire Laser for Treatment of Kratom‐Induced Hyperpigmentation

Lasers in Surgery and Medicine, Volume 57, Issue 5, Page 373-382, July 2025.
ABSTRACT Objectives This case series reports the use of the 730‐nm picosecond titanium‐sapphire laser in the treatment of kratom‐induced hyperpigmentation, a dermatological side effect associated with the use of Mitragyna speciosa, which remains poorly understood. Methods A series of patients with kratom‐induced hyperpigmentation were treated using the
Alanoud A. Alhadyani, Christen Samaan, Girish S. Munavalli   +2 more
wiley   +1 more source

From data to discovery: leveraging big data in plant natural products biosynthesis research

The Plant Journal, Volume 122, Issue 6, June 2025.
SUMMARY Plant natural products or specialized metabolites play a vital role in drug discovery and development, with many clinically important derivatives such as the anticancer drugs topotecan (derived from the natural alkaloid camptothecin) and etoposide (derived from the natural polyphenol podophyllotoxin).
Matthew McConnachie, Tuan‐Anh Minh Nguyen, Truc Kim, Trinh‐Don Nguyen, Thu‐Thuy T. Dang   +4 more
wiley   +1 more source