Results 21 to 30 of about 2,738 (175)
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Applications in Plant Sciences, Volume 11, Issue 6, November-December 2023., 2023 Abstract Premise Rubiaceae is among the most species‐rich plant families, as well as one of the most morphologically and geographically diverse. Currently available phylogenies have mostly relied on few genomic and plastid loci, as opposed to large‐scale genomic data.
Laymon D. Ball +3 more
wiley +1 more source
Biosynthesis of kratom opioids
New Phytologist, Volume 240, Issue 2, Page 757-769, October 2023., 2023 Summary Mitragynine, an analgesic alkaloid from the plant Mitragyna speciosa (kratom), offers a safer alternative to clinical opioids such as morphine, owing to its more favorable side effect profile. Although kratom has been traditionally used for stimulation and pain management in Southeast Asia, the mitragynine biosynthesis pathway has remained ...
Kyunghee Kim +6 more
wiley +1 more source
Kratom use disorder as a gateway to an opioid use disorder
European Psychiatry, 2023 Introduction Kratom (Mitragyna speciosa) is a psychoactive substance native to Thailand and Southeast Asia with stimulant-like effects at lower doses and opioid-like effects at higher doses.
A. C. Borges, D. Machado
doaj +1 more source
Sedative, cognitive impairment and anxiolytic effects of acute Mitragyna speciosa in rodents [PDF]
, 2013 Mitragyna speciosa, a plant from Rubiaceae family, was reported to have an opium-like effect and their coca-like stimulative ability to combat fatigue and enhance tolerance to hard work.
Adzhar, Muhammad Farhan +10 more
core +1 more source
Clinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom
Clinical Pharmacology &Therapeutics, Volume 113, Issue 6, Page 1315-1325, June 2023., 2023 Oral formulations prepared from the leaves of the kratom (Mitragyna speciosa) plant are increasingly used for their opioid‐like effects to self‐manage opioid withdrawal and pain. Calls to US poison centers involving kratom exposures increased >50‐fold from 2011–2017, one‐third of which reported concomitant use of kratom with drugs of abuse.
Rakshit S. Tanna +9 more
wiley +1 more source
EduChemia, 2023 Kratom leaves are known as traditional medicine with various benefits, such as antibacterial, antimicrobial, and antioxidant properties. These benefits are attributed to the presence of secondary metabolites, particularly mitragynine.
Syrifah Nur Intan Mutiara +4 more
doaj +1 more source
The dark web trades wildlife, but mostly for use as drugs
People and Nature, Volume 5, Issue 3, Page 999-1009, June 2023., 2023 Abstract Contemporary wildlife trade is massively facilitated by the Internet. By design, the dark web is one layer of the Internet that is difficult to monitor and continues to lack thorough investigation. Here, we accessed a comprehensive database of dark web marketplaces to search across c. 2 million dark web advertisements over 5 years using c. 7 k
Oliver C. Stringham +14 more
wiley +1 more source
Herbal highs: review on psychoactive effects and neuropharmacology [PDF]
, 2017 Background: A new trend among users of new psychoactive substances’ the consumption of “herbal highs”: plant parts containing psychoactive substances.
Graziano, S +5 more
core +1 more source
Clinical and Translational Science, Volume 16, Issue 6, Page 1002-1011, June 2023., 2023 Abstract Kratom is a widely used Asian botanical that has gained popularity in the United States due to a perception that it can treat pain, anxiety, and opioid withdrawal symptoms. The American Kratom Association estimates 10–16 million people use kratom.
Xiaotong Li +8 more
wiley +1 more source